Disease relevance of Hyperoside

• The flavonoids hyperoside, isoquercitrin and quercitrin (all at 0.6 mg/kg, P. O.) and rutin (1 mg/kg, P. O.) only partially blocked OF-induced hyperthermia [1].

Psychiatry related information on Hyperoside

• It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level [2].

High impact information on Hyperoside

• Previous studies refer mostly to the HPLC analysis of the flavonoids: vitexin, quercetin, hyperoside, oligomeric procyanidins, which appear to be primarily responsible for the cardiac action of the plant [3].
• Plasma levels of hypericin in rats in the presence and absence of procyanidin B2 or hyperoside were determined by reversed phase HPLC using fluorimetric detection [4].
• Procyanidin B2 and hyperoside had a different influence on the plasma kinetics of hypericin; median maximal plasma levels of hypericin were detected after 360 min (C max : 8.6 ng/mL) for B2, and after 150 min (C max : 8.8 ng/mL) for hyperoside [4].
• Both compounds increased the oral bioavailability of hypericin by ca. 58 % (B2) and 34 % (hyperoside) [4].
• In the Caco-2 cell line, miquelianin showed a higher uptake (1.93 +/- 0.9 pmol x min(-1) x cm(-2)) than hyperoside (quercetin 3-O-beta-D-galactopyranoside; 0.55 +/- 0.18 pmol x min(-1) x cm(-2)) and quercitrin (quercetin 3-O-alpha-L-rhamnopyranoside; 0.22 +/- 0.08 pmol x min(-1) x cm(-2)) [5].

Biological context of Hyperoside

• While inhibition of leukotriene biosynthesis was not mediated by its known phenolic constituents such as hyperoside, rutoside, and chlorogenic acid, these compounds were responsible for the inhibitory effects of I. aquifolium against non-enzymatic lipid peroxidation and deoxyribose degradation [6].
• Treatment with hypericin led to a significant down-regulation (13%) of beta-AR's in the frontal cortex after 8-weeks, but not after 2 weeks, while hyperforin (used as trimethoxybenzoate, TMB), and hyperoside were ineffective in both treatment paradigms [7].
• All the above results showed hyperoside could efficiently prevent the PC12 cells from shrinking and turning against apoptosis induced by hydrogen peroxide and tert-butyl hydroperoxide [8].
• In this study the effects of flavonoids (quercetin and its derivatives as rutin, hyperoside, quercitrin) on the oxidative phosphorylation in rat heart mitochondria were investigated [9].
• Interesting results were also observed for hyperoside with IC50 = 8.3 microm for urokinase [10].

Anatomical context of Hyperoside

• In this paper, PC12 cells were used to study the antioxidative effect of hyperoside [8].
• However, a stronger inhibitory effect of hyperoside on the enzyme was discerned in cerebrum than in blood [11].

Associations of Hyperoside with other chemical compounds

• Five flavonoids (hyperoside, isoquercitrin, quercitrin, quercetin and rutin) were separated and determined in extracts of Hypericum perforatum leaves or flowers by capillary zone electrophoresis (CZE) with isotachophoretic (ITP) sample pre-treatment using on-line column coupling configuration [12].
• The 74 samples of six HYPERICUM species (H. PERFOROTUM, H. HIRSUTUM, H. MACULATUM, H. TETRAPTERUM, H. MONTANUM, AND H. HUMIFUSUM) were collected around Slovenia and analysed for the content of ten substances (rutin, hyperoside, isoquercetin, quercitrin, quercetin, I3,II8-biapigenin, amentoflavone, pseudohypericin, hypericin, and hyperforin) [13].
• The flavonoid glycosides vitexin, vitexin 2- O-rhamnoside, rutin, and hyperoside, as well as the aglycones apigenin, luteolin, and quercetin, could be detected by TLC and HPLC in, however, varying amounts [14].
• Highly selective liquid chromatography/tandem mass spectrometry analysis showed that the content of six investigated active compounds (hypericin, pseudohypericin, hyperoside, rutin, quercitrin, and hyperforin) in extracts obtained by direct sonication was significantly higher than in extracts obtained by the other methods [15].
• Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata [16].

Analytical, diagnostic and therapeutic context of Hyperoside

• The ITP-CZE results for rutin, hyperoside, and vitexin-2-O"-rhamnoside were in good accordance with those obtained previously by high-performance liquid chromatography [17].

References