The purine path to chemotherapy.
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).[1]References
- The purine path to chemotherapy. Elion, G.B. Science (1989) [Pubmed]
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