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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Transplants


Psychiatry related information on Transplants


High impact information on Transplants


Chemical compound and disease context of Transplants


Biological context of Transplants


Anatomical context of Transplants


Associations of Transplants with chemical compounds

  • In a second series of experiments, addition of lazaroids to dissociated mesencephalic graft tissue increased the yield of surviving rat dopamine neurons 2.6-fold after implantation in the dopamine-denervated rat striatum [29].
  • We hypothesized that the antioxidant bucillamine, a potent sulfhydryl donor, would protect against I/R injury in high-risk organ transplants [30].
  • They contained striatum-like patches with neurons expressing many of the neurochemicals characteristic of striatum (ACh, ChAT, calbindin-D28KD, met-enkephalin, and dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein-32,000 or DARPP-32), and these patches were surrounded by graft tissue expressing few of these striatal markers [31].
  • When routes of cell transplant and treatment were different, no therapeutic advantage of DNM:DNA over DNM was seen [32].
  • The preclinical and clinical characterization of Brequinar sodium has demonstrated the potential for the use of this drug as a component of a polytherapeutic treatment strategy to prevent the rejection of organ grafts [33].

Gene context of Transplants


Analytical, diagnostic and therapeutic context of Transplants


  1. Undifferentiated cell transplant techniques appear effective in treating leg ulcers, vitiligo. Skolnick, A.A. JAMA (1991) [Pubmed]
  2. Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium. Brown, G.R., Thiele, D.L., Silva, M., Beutler, B. Gastroenterology (1997) [Pubmed]
  3. Linking Chinese medicine and G-protein-coupled receptors. Im, D.S. Trends Pharmacol. Sci. (2003) [Pubmed]
  4. Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation--a randomized double-blind placebo-controlled study. Boeckh, M., Kim, H.W., Flowers, M.E., Meyers, J.D., Bowden, R.A. Blood (2006) [Pubmed]
  5. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Erard, V., Kim, H.W., Corey, L., Limaye, A., Huang, M.L., Myerson, D., Davis, C., Boeckh, M. Blood (2005) [Pubmed]
  6. Neural transplantation of hNT neurons for Huntington's disease. Hurlbert, M.S., Gianani, R.I., Hutt, C., Freed, C.R., Kaddis, F.G. Cell transplantation. (1999) [Pubmed]
  7. Effect of lithium on cyclosporin induced nephrotoxicity in rats. Tariq, M., Morais, C., Sobki, S., Al Sulaiman, M., Al Khader, A. Renal failure. (2000) [Pubmed]
  8. Sedative drug requirements during flexible bronchoscopy. Chhajed, P.N., Wallner, J., Stolz, D., Baty, F., Strobel, W., Brutsche, M.H., Tamm, M. Respiration; international review of thoracic diseases. (2005) [Pubmed]
  9. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K.M., Luzzatto, L., Sadelain, M. Nature (2000) [Pubmed]
  10. Identification of a mouse male-specific transplantation antigen, H-Y. Scott, D.M., Ehrmann, I.E., Ellis, P.S., Bishop, C.E., Agulnik, A.I., Simpson, E., Mitchell, M.J. Nature (1995) [Pubmed]
  11. Cyclosporin A binding to calmodulin: a possible site of action on T lymphocytes. Colombani, P.M., Robb, A., Hess, A.D. Science (1985) [Pubmed]
  12. Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients. Corpier, C.L., Jones, P.H., Suki, W.N., Lederer, E.D., Quinones, M.A., Schmidt, S.W., Young, J.B. JAMA (1988) [Pubmed]
  13. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. Stuart, P.M., Griffith, T.S., Usui, N., Pepose, J., Yu, X., Ferguson, T.A. J. Clin. Invest. (1997) [Pubmed]
  14. Cyclosporin A inhibits creatine uptake by altering surface expression of the creatine transporter. Tran, T.T., Dai, W., Sarkar, H.K. J. Biol. Chem. (2000) [Pubmed]
  15. Side effects of systemic cyclosporine in patients not undergoing transplantation. Palestine, A.G., Nussenblatt, R.B., Chan, C.C. Am. J. Med. (1984) [Pubmed]
  16. Failure of high-dose oral acyclovir with or without immune globulin to prevent primary cytomegalovirus disease in recipients of solid organ transplants. Bailey, T.C., Ettinger, N.A., Storch, G.A., Trulock, E.P., Hanto, D.W., Dunagan, W.C., Jendrisak, M.D., McCullough, C.S., Kenzora, J.L., Powderly, W.G. Am. J. Med. (1993) [Pubmed]
  17. Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression. Berenguer, J., Allende, M.C., Lee, J.W., Garrett, K., Lyman, C., Ali, N.M., Bacher, J., Pizzo, P.A., Walsh, T.J. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  18. Metabolism-based cyclophosphamide dosing for hematopoietic cell transplant. McDonald, G.B., McCune, J.S., Batchelder, A., Cole, S., Phillips, B., Ren, A.G., Vicini, P., Witherspoon, R., Kalhorn, T.F., Slattery, J.T. Clin. Pharmacol. Ther. (2005) [Pubmed]
  19. The use of monoclonal antibodies to achieve immunological tolerance. Waldmann, H., Cobbold, S. Trends Pharmacol. Sci. (1993) [Pubmed]
  20. Therapeutic benefits of calcium channel blockers in cyclosporine-treated organ transplant recipients: blood pressure control and immunosuppression. Weir, M.R. Am. J. Med. (1991) [Pubmed]
  21. Pax6 regulates cell adhesion during cortical development. Tyas, D.A., Pearson, H., Rashbass, P., Price, D.J. Cereb. Cortex (2003) [Pubmed]
  22. ZAP-70 upregulation in transformed B cells after early pre-BI cell transplant into NOD/SCID mice. Ruiz-Vela, A., Piqueras, R., Carvalho-Pinto, C., Gómez, L., Yaniz-Galende, E., Moreno-Ortiz, M.C., Bernad, A., Harshman, K., Martínez-A, C. Oncogene (2005) [Pubmed]
  23. Mechanism of action of cyclosporine in preventing cardiac allograft rejection. II. Graft tissue levels of prostacyclin and thromboxane. Fan, T.P., Cox, J.H., Chisholm, P.M. Transplantation (1987) [Pubmed]
  24. De novo generation of CD4 T cells against viruses present in the host during immune reconstitution. Kalina, T., Lu, H., Zhao, Z., Blewett, E., Dittmer, D.P., Randolph-Habecker, J., Maloney, D.G., Andrews, R.G., Kiem, H.P., Storek, J. Blood (2005) [Pubmed]
  25. Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Offman, J., Opelz, G., Doehler, B., Cummins, D., Halil, O., Banner, N.R., Burke, M.M., Sullivan, D., Macpherson, P., Karran, P. Blood (2004) [Pubmed]
  26. Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-gamma. Miura, M., El-Sawy, T., Fairchild, R.L. Am. J. Pathol. (2003) [Pubmed]
  27. Endothelial sulfated sialyl Lewis x glycans, putative L-selectin ligands, are preferentially expressed in bronchial asthma but not in other chronic inflammatory lung diseases. Toppila, S., Paavonen, T., Laitinen, A., Laitinen, L.A., Renkonen, R. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  28. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Gouras, P., Du, J., Kjeldbye, H., Yamamoto, S., Zack, D.J. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  29. Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Nakao, N., Frodl, E.M., Duan, W.M., Widner, H., Brundin, P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Amersi, F., Nelson, S.K., Shen, X.D., Kato, H., Melinek, J., Kupiec-Weglinski, J.W., Horwitz, L.D., Busuttil, R.W., Horwitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  31. Influence of mesostriatal afferents on the development and transmitter regulation of intrastriatal grafts derived from embryonic striatal primordia. Liu, F.C., Dunnett, S.B., Graybiel, A.M. J. Neurosci. (1992) [Pubmed]
  32. Pharmacological and therapeutic efficacy of daunomycin:DNA complex in mice. Ohnuma, T., Holland, J.F., Chen, J.H. Cancer Res. (1975) [Pubmed]
  33. The development of Brequinar as an immunosuppressive drug for transplantation. Makowka, L., Sher, L.S., Cramer, D.V. Immunol. Rev. (1993) [Pubmed]
  34. Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. Nechiporuk, A., Linbo, T., Raible, D.W. Development (2005) [Pubmed]
  35. Prolonged allograft survival in TNF receptor 1-deficient recipients is due to immunoregulatory effects, not to inhibition of direct antigraft cytotoxicity. McKee, C.M., Defina, R., He, H., Haley, K.J., Stone, J.R., Perkins, D.L. J. Immunol. (2002) [Pubmed]
  36. Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases. Meng, C.Q., Somers, P.K., Hoong, L.K., Zheng, X.S., Ye, Z., Worsencroft, K.J., Simpson, J.E., Hotema, M.R., Weingarten, M.D., MacDOnald, M.L., Hill, R.R., Marino, E.M., Suen, K.L., Luchoomun, J., Kunsch, C., Landers, L.K., Stefanopoulos, D., Howard, R.B., Sundell, C.L., Saxena, U., Wasserman, M.A., Sikorski, J.A. J. Med. Chem. (2004) [Pubmed]
  37. In vivo effects of cytokines on psoriatic skin grafted on nude mice: involvement of the tumour necrosis factor (TNF) receptor. Gilhar, A., David, M., Kalish, R.S., Weisinger, G. Clin. Exp. Immunol. (1996) [Pubmed]
  38. Prolactin receptors on large granular lymphocytes: dual regulation by cyclosporin A. Matera, L., Muccioli, G., Cesano, A., Bellussi, G., Genazzani, E. Brain Behav. Immun. (1988) [Pubmed]
  39. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Grimm, S.L., Seagroves, T.N., Kabotyanski, E.B., Hovey, R.C., Vonderhaar, B.K., Lydon, J.P., Miyoshi, K., Hennighausen, L., Ormandy, C.J., Lee, A.V., Stull, M.A., Wood, T.L., Rosen, J.M. Mol. Endocrinol. (2002) [Pubmed]
  40. Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals. Purdie, K.J., Surentheran, T., Sterling, J.C., Bell, L., McGregor, J.M., Proby, C.M., Harwood, C.A., Breuer, J. J. Invest. Dermatol. (2005) [Pubmed]
  41. Pharmacokinetic profile of ganciclovir after its oral administration and from its prodrug, valganciclovir, in solid organ transplant recipients. Wiltshire, H., Hirankarn, S., Farrell, C., Paya, C., Pescovitz, M.D., Humar, A., Dominguez, E., Washburn, K., Blumberg, E., Alexander, B., Freeman, R., Heaton, N. Clinical pharmacokinetics. (2005) [Pubmed]
  42. A method for transplantation of luteinizing granulosa cells: evidence for progesterone secretion. Farookhi, R., Keyes, P.L., Kahn, L.E. Biol. Reprod. (1982) [Pubmed]
  43. Muscarinic cholinergic receptors in normal pediatric and myelodysplastic bladders. Gup, D.I., Baumann, M., Lepor, H., Shapiro, E. J. Urol. (1989) [Pubmed]
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