The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metabolic effects of intraruminal administration of 1,3-butanediol or tributyrin in lactating goats.

Acute effects of dietary 1,3-butanediol and tributyrin on concentrations of glucose, beta-hydroxybutyrate, and insulin in plasma were compared in lactating goats. In Experiment 1, glucose was decreased by intraruminal administration of 75 or 150 g of 1,3-butanediol or by 84 or 168 g of tributyrin. Tributyrin caused transient hyperglycemia immediately after administration. beta-Hydroxybutyrate was increased in a dose-dependent manner by tributyrin and increased independently of dose by 1,3-butanediol. Tributyrin, but not 1,3-butanediol. Tributyrin, but not 1,3-butanediol, caused large increases of insulin in plasma. In Experiment 2, 75 g of 1,3-butanediol or 84 g of tributyrin administered intraruminally decreased glucose, whereas 73 g of butyric acid (pH 5.6) increased glucose compared with water or 25.6 g of glycerol. All treatments produced transient hyperglycemia immediately after administration. Tributyrin, butyric acid, or 1,3-butanediol greatly increased beta-hydroxybutyrate compared with administration of water or glycerol. Concentrations of beta-hydroxybutyrate in both experiments increased more slowly for 1,3-butanediol than for tributyrin. Both 1,3-butanediol and tributyrin decreased glucose and increased beta-hydroxybutyrate. Because 1,3-butanediol does not stimulate increases of insulin in plasma, it may be more desirable than tributyrin for inducing metabolic changes characteristic of lactation ketosis.[1]


  1. Metabolic effects of intraruminal administration of 1,3-butanediol or tributyrin in lactating goats. Drackley, J.K., Zhang, Y., Amaral, D.M., Young, J.W. J. Dairy Sci. (1989) [Pubmed]
WikiGenes - Universities