The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Tributin     2,3-dibutanoyloxypropyl butanoate

Synonyms: Butyrin, TRIBUTYRIN, Tributyroin, Tributyrinine, Tri-n-butyrin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Glycerol tributanoate


Psychiatry related information on Glycerol tributanoate


High impact information on Glycerol tributanoate


Chemical compound and disease context of Glycerol tributanoate


Biological context of Glycerol tributanoate


Anatomical context of Glycerol tributanoate


Associations of Glycerol tributanoate with other chemical compounds

  • Replacing the loop of LPL with the loop of hepatic lipase, which differs in 15 of 22 amino acids but is also amphiphilic, led to the expression of an enzyme that retained both triolein and tributyrin hydrolyzing activity [24].
  • Replacing HL Ser147 with glycine also resulted in a protein with little or no measurable activity for tributyrin, a substrate which does not provide a lipid interface [25].
  • A monospecific anti-HL polyclonal antibody interacting with the C-terminal HL-derived domain of the chimeric enzyme abolished the enzyme's ability to hydrolyze triglyceride emulsion but not tributyrin substrates [26].
  • Pig pancreatic carboxylester lipase (cholesterol esterase, E.C. was inactivated at a tributyrin/water interface [27].
  • Similar crosses were set up involving parental flies with normally heterozygous genetic background as a control.--Significant deviations from mendelian expectation were observed in inbred E-5 flies grown on tributyrin, inbred ODH males grown on octanol, and inbred ODH females grown on ethanol [28].

Gene context of Glycerol tributanoate


Analytical, diagnostic and therapeutic context of Glycerol tributanoate


  1. Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Munshi, A., Kurland, J.F., Nishikawa, T., Tanaka, T., Hobbs, M.L., Tucker, S.L., Ismail, S., Stevens, C., Meyn, R.E. Clin. Cancer Res. (2005) [Pubmed]
  2. Cloning, sequencing, and role in virulence of two phospholipases (A1 and C) from mesophilic Aeromonas sp. serogroup O:34. Merino, S., Aguilar, A., Nogueras, M.M., Regue, M., Swift, S., Tomás, J.M. Infect. Immun. (1999) [Pubmed]
  3. Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines. Maier, S., Reich, E., Martin, R., Bachem, M., Altug, V., Hautmann, R.E., Gschwend, J.E. Int. J. Cancer (2000) [Pubmed]
  4. Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice. Giermasz, A., Makowski, M., Kozłowska, E., Nowis, D., Maj, M., Jalili, A., Feleszko, W., Wójcik, C., Dabrowska, A., Jakóbisiak, M., Gołab, J. Int. J. Cancer (2002) [Pubmed]
  5. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. Gaschott, T., Steinhilber, D., Milovic, V., Stein, J. J. Nutr. (2001) [Pubmed]
  6. Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity. Heerdt, B.G., Houston, M.A., Anthony, G.M., Augenlicht, L.H. Cancer Res. (1999) [Pubmed]
  7. Gastric lipase in alcoholic pancreatitis. Comparison of secretive profiles following pentagastrin stimulation in normal adults and patients with pancreatic insufficiency. Moreau, J., Bouisson, M., Balas, D., Ravaud, A., Stupnik, S., Buscail, L., Vaysse, N., Ribet, A. Gastroenterology (1990) [Pubmed]
  8. Kinetic assay of human gastric lipase on short- and long-chain triacylglycerol emulsions. Gargouri, Y., Pieroni, G., Riviere, C., Sauniere, J.F., Lowe, P.A., Sarda, L., Verger, R. Gastroenterology (1986) [Pubmed]
  9. Branhamella catarrhalis: an organism gaining respect as a pathogen. Catlin, B.W. Clin. Microbiol. Rev. (1990) [Pubmed]
  10. Purification and substrate specificity of polymorphic forms of esterase D from human erythrocytes. Scott, E.M., Wright, R.C. Am. J. Hum. Genet. (1978) [Pubmed]
  11. Differentiation of androgen-independent prostate cancer PC-3 cells is associated with increased nuclear factor-kappaB activity. Floryk, D., Huberman, E. Cancer Res. (2005) [Pubmed]
  12. Selenomonas lipolytica sp. nov., an obligately anaerobic bacterium possessing lipolytic activity. Dighe, A.S., Shouche, Y.S., Ranade, D.R. Int. J. Syst. Bacteriol. (1998) [Pubmed]
  13. Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer. Kuefer, R., Hofer, M.D., Altug, V., Zorn, C., Genze, F., Kunzi-Rapp, K., Hautmann, R.E., Gschwend, J.E. Br. J. Cancer (2004) [Pubmed]
  14. Alteration of chain length selectivity of a Rhizopus delemar lipase through site-directed mutagenesis. Joerger, R.D., Haas, M.J. Lipids (1994) [Pubmed]
  15. Tributyrin inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. Yan, J., Xu, Y.H. World J. Gastroenterol. (2003) [Pubmed]
  16. Counteractive effects of propionate or 1,2-propanediol against hypoglycemia and ketonemia of tributyrin-treated cows. Hamada, T., Hodate, K., Matsumoto, M., Ishii, T. J. Dairy Sci. (1984) [Pubmed]
  17. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Guan, R.J., Ford, H.L., Fu, Y., Li, Y., Shaw, L.M., Pardee, A.B. Cancer Res. (2000) [Pubmed]
  18. Human plasma carboxyl esterase-catalyzed triolein hydrolysis. Existence of promoting factor in serum. Shirai, K., Ohsawa, I., Ishikawa, Y., Saito, Y., Yoshida, S. J. Biol. Chem. (1985) [Pubmed]
  19. Quantitative spectrophotometric assay for staphylococcal lipase. Smeltzer, M.S., Hart, M.E., Iandolo, J.J. Appl. Environ. Microbiol. (1992) [Pubmed]
  20. Evaluation of tributyrin lipid emulsion with affinity to low-density lipoprotein: pharmacokinetics in adult male Wistar rats and cellular activity on Caco-2 and HepG2 cell lines. Su, J., He, L., Zhang, N., Ho, P.C. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  21. Characterization of the extracellular lipase, LipA, of Acinetobacter calcoaceticus BD413 and sequence analysis of the cloned structural gene. Kok, R.G., van Thor, J.J., Nugteren-Roodzant, I.M., Brouwer, M.B., Egmond, M.R., Nudel, C.B., Vosman, B., Hellingwerf, K.J. Mol. Microbiol. (1995) [Pubmed]
  22. Tributyrin enhances the cytotoxic activity of interleukin-2/interleukin-12 stimulated human natural killer cells against LS 174T colon cancer cells in vitro. Schröder, C.P., Maurer, H.R. Cancer Immunol. Immunother. (2001) [Pubmed]
  23. Functional expression and refolding of new alkaline esterase, EM2L8 from deep-sea sediment metagenome. Park, H.J., Jeon, J.H., Kang, S.G., Lee, J.H., Lee, S.A., Kim, H.K. Protein Expr. Purif. (2007) [Pubmed]
  24. Human lipoprotein lipase: the loop covering the catalytic site is essential for interaction with lipid substrates. Dugi, K.A., Dichek, H.L., Talley, G.D., Brewer, H.B., Santamarina-Fojo, S. J. Biol. Chem. (1992) [Pubmed]
  25. Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity. Davis, R.C., Stahnke, G., Wong, H., Doolittle, M.H., Ameis, D., Will, H., Schotz, M.C. J. Biol. Chem. (1990) [Pubmed]
  26. Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase. Dichek, H.L., Parrott, C., Ronan, R., Brunzell, J.D., Brewer, H.B., Santamarina-Fojo, S. J. Lipid Res. (1993) [Pubmed]
  27. Effect of bile salts on the interfacial inactivation of pancreatic carboxylester lipase. Tsujita, T., Okuda, H. J. Lipid Res. (1990) [Pubmed]
  28. Further evidence for selective differences between isoalleles in Drosophila. Wills, C., Phelps, J., Ferguson, R. Genetics (1975) [Pubmed]
  29. Lipoprotein lipase with a defect in lipid interface recognition in a case with type I hyperlipidaemia. Kobayashi, J., Shirai, K., Saito, Y., Yoshida, S. Eur. J. Clin. Invest. (1989) [Pubmed]
  30. Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Egorin, M.J., Yuan, Z.M., Sentz, D.L., Plaisance, K., Eiseman, J.L. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  31. Determination of tributyrin and its metabolite butyrate in Wistar rat plasma samples by gas chromatography/mass spectrometry. Su, J., Zhang, N., Ho, P.C. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
  32. Inhibition of human gastric lipase by intraduodenal fat involves glucagon-like peptide-1 and cholecystokinin. Wøjdemann, M., Riber, C., Bisgaard, T., Sternby, B., Larsen, S., Rehfeld, J.F., Holst, J.J., Olsen, O. Regul. Pept. (1999) [Pubmed]
WikiGenes - Universities