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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Black currant seed oil feeding and fatty acids in liver lipid classes of guinea pigs.

Guinea pigs were fed one of three diets containing 10% black currant seed oil (a source of gamma-linolenic (18:3 n-6) and stearidonic (18:4 n-3) acids), walnut oil or lard for 40 days. The fatty acid composition of liver triglycerides, free fatty acids, cholesteryl esters, phosphatidylinositol, phosphatidylserine, cardiolipin, phosphatidylcholine and phosphatidylethanolamine were determined. Dietary n-3 fatty acids found esterified in liver lipids had been desaturated and elongated to longer chain analogues, notably docosapentaenoic acid (22:5 n-3) and docosahexaenoic acid (22:6 n-3). When the diet contained low amounts of n-6 fatty acids, proportionately more of the n-3 fatty acids were transformed. Significantly more eicosapentaenoic acid (EPA) (20:5 n-3) was incorporated into triglycerides, cholesteryl esters, phosphatidylcholine and phosphatidylethanolamine of the black currant seed oil group compared with the walnut oil group. Feeding black currant seed oil resulted in significant increases of dihomogamma-linolenic acid (20:3 n-6) in all liver lipid classes examined, whereas the levels of arachidonic acid (20:4 n-6) remained relatively stable. The ratio dihomo-gamma-linolenic acid/arachidonic acid was significantly (2.5-fold in PI to 17-fold in cholesteryl esters) higher in all lipid classes from the black currant seed oil fed group.[1]


  1. Black currant seed oil feeding and fatty acids in liver lipid classes of guinea pigs. Crozier, G.L., Fleith, M., Traitler, H., Finot, P.A. Lipids (1989) [Pubmed]
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