The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1O5FY9     (6Z,9Z,12Z)-icosa-6,9,12- trienoic acid

Synonyms: 135625-06-8, UNII-FC398RK06S, EINECS 217-233-0
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Dihomo-gamma-linolenic acid

 

Psychiatry related information on Dihomo-gamma-linolenic acid

  • After adjusting for age, gender, smoking, alcohol drinking, sports activity, and non-FA dietary factors, the incidence of CHD was significantly and positively associated with the proportion of dihomo-gamma-linolenic acid but inversely associated with arachiadonic acid [6].
 

High impact information on Dihomo-gamma-linolenic acid

 

Chemical compound and disease context of Dihomo-gamma-linolenic acid

 

Biological context of Dihomo-gamma-linolenic acid

 

Anatomical context of Dihomo-gamma-linolenic acid

 

Associations of Dihomo-gamma-linolenic acid with other chemical compounds

 

Gene context of Dihomo-gamma-linolenic acid

 

Analytical, diagnostic and therapeutic context of Dihomo-gamma-linolenic acid

References

  1. Dihomo-gamma-linolenic acid as the endogenous protective agent for myocardial infarction. Willis, A.L. Lancet (1984) [Pubmed]
  2. Mutagenesis of some conserved residues in human 5-lipoxygenase: effects on enzyme activity. Zhang, Y.Y., Rådmark, O., Samuelsson, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Liver fatty acids and the sudden infant death syndrome. Fogerty, A.C., Ford, G.L., Willcox, M.E., Clancy, S.L. Am. J. Clin. Nutr. (1984) [Pubmed]
  4. Dihomo-gamma-linolenic acid, prostaglandins and dyskinesias. Costall, B., Holmes, S.W., Kelly, M.E., Naylor, R.J. Prog. Lipid Res. (1986) [Pubmed]
  5. Dihomo-gamma-linolenic acid reverses hypertension induced in rats by diets rich in saturated fat. Hassall, C.H., Kirtland, S.J. Lipids (1984) [Pubmed]
  6. Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Wang, L., Folsom, A.R., Eckfeldt, J.H. Nutrition, metabolism, and cardiovascular diseases : NMCD. (2003) [Pubmed]
  7. The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Vessby, B., Aro, A., Skarfors, E., Berglund, L., Salminen, I., Lithell, H. Diabetes (1994) [Pubmed]
  8. Suppression of human synovial cell proliferation by dihomo-gamma-linolenic acid. Baker, D.G., Krakauer, K.A., Tate, G., Laposata, M., Zurier, R.B. Arthritis Rheum. (1989) [Pubmed]
  9. cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. Leonard, A.E., Kelder, B., Bobik, E.G., Chuang, L.T., Parker-Barnes, J.M., Thurmond, J.M., Kroeger, P.E., Kopchick, J.J., Huang, Y.S., Mukerji, P. Biochem. J. (2000) [Pubmed]
  10. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. Marra, F., Riccardi, D., Melani, L., Spadoni, S., Galli, C., Fabrizio, P., Tosti-Guerra, C., Carloni, V., Gentilini, P., Laffi, G. J. Hepatol. (1998) [Pubmed]
  11. Prolactin and zinc effects on rat vascular reactivity: possible relationship to dihomo-gamma-linolenic acid and to prostaglandin synthesis. Manku, M.S., Horrobin, D.F., Karmazyn, M., Cunnane, S.C. Endocrinology (1979) [Pubmed]
  12. Heneicosapentaenoate (21:5n-3): its incorporation into lipids and its effects on arachidonic acid and eicosanoid synthesis. Larsen, L.N., Høvik, K., Bremer, J., Holm, K.H., Myhren, F., Børretzen, B. Lipids (1997) [Pubmed]
  13. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Leonhardt, A., Krauss, M., Gieler, U., Schweer, H., Happle, R., Seyberth, H.W. Br. J. Dermatol. (1997) [Pubmed]
  14. Polyunsaturated fatty acids in plasma, red blood cells and mononuclear cell phospholipids of patients with atopic dermatitis. Lindskov, R., Hølmer, G. Allergy (1992) [Pubmed]
  15. Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus: effect of omega-6 fatty acids. Suresh, Y., Das, U.N. Nutrition (Burbank, Los Angeles County, Calif.) (2003) [Pubmed]
  16. Arachidonic acid predominates in the membrane phosphoglycerides of the early and term human placenta. Bitsanis, D., Crawford, M.A., Moodley, T., Holmsen, H., Ghebremeskel, K., Djahanbakhch, O. J. Nutr. (2005) [Pubmed]
  17. Eskimo plasma constituents, dihomo-gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid inhibit the release of atherogenic mitogens. Smith, D.L., Willis, A.L., Nguyen, N., Conner, D., Zahedi, S., Fulks, J. Lipids (1989) [Pubmed]
  18. Effects of different dietary intake of essential fatty acids on C20:3 omega 6 and C20:4 omega 6 serum levels in human adults. Lasserre, M., Mendy, F., Spielmann, D., Jacotot, B. Lipids (1985) [Pubmed]
  19. Is the origin of atopy linked to deficient conversion of omega-6-fatty acids to prostaglandin E1? Melnik, B.C., Plewig, G. J. Am. Acad. Dermatol. (1989) [Pubmed]
  20. Mechanism of action of arachidonic acid in the isolated perfused rat heart. Shaffer, J.E., Malik, K.U. Can. J. Physiol. Pharmacol. (1984) [Pubmed]
  21. Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. Barham, J.B., Edens, M.B., Fonteh, A.N., Johnson, M.M., Easter, L., Chilton, F.H. J. Nutr. (2000) [Pubmed]
  22. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. Abraham, R.D., Riemersma, R.A., Elton, R.A., Macintyre, C., Oliver, M.F. Atherosclerosis (1990) [Pubmed]
  23. Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. McKean, M.L., Silver, M.J., Authi, K.S., Crawford, N. FEBS Lett. (1986) [Pubmed]
  24. Triglycerides, lipid droplets, and lysosomes in aorta smooth muscle cells during the control of cell proliferation with polyunsaturated fatty acids and vitamin E. Miller, J.S., Gavino, V.C., Ackerman, G.A., Sharma, H.M., Milo, G.E., Geer, J.C., Cornwell, D.G. Lab. Invest. (1980) [Pubmed]
  25. Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats. Raederstorff, D., Moser, U. Lipids (1992) [Pubmed]
  26. Effect of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures. Gavino, V.C., Miller, J.S., Ikharebha, S.O., Milo, G.E., Cornwell, D.G. J. Lipid Res. (1981) [Pubmed]
  27. Supplementation with evening primrose oil in atopic dermatitis: effect on fatty acids in neutrophils and epidermis. Schäfer, L., Kragballe, K. Lipids (1991) [Pubmed]
  28. Lipid storage in cultured articular chondrocytes due to prostanoid precursors and a prostanoid synthesis inhibitor. Kirkpatrick, C.J., Mohr, W., Haferkamp, O. Cell Tissue Res. (1982) [Pubmed]
  29. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., Flouri, S., Mantzoros, C., Kafatos, A. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  30. Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. Williams, W.V., Rosenbaum, H., Zurier, R.B. Pathobiology (1996) [Pubmed]
  31. Evidence that suppression of IL-1 induced collagenase mRNA expression by dihomo-gamma-linolenic acid (DGLA) involves inhibition of NF kappa B binding. Borghaei, H., Borghaei, R.C., Ni, X., Pease, E., Thornton, R., Mochan, E. Inflamm. Res. (1997) [Pubmed]
  32. Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? Das, U.N. The Journal of the Association of Physicians of India. (2005) [Pubmed]
  33. Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid. Fan, Y.Y., Chapkin, R.S. J. Nutr. (1992) [Pubmed]
  34. Plasma cholesteryl ester fatty acid composition, insulin sensitivity, the menopause and hormone replacement therapy. Lewis-Barned, N.J., Sutherland, W.H., Walker, R.J., de Jong, S.A., Walker, H.L., Edwards, E.A., Markham, V., Goulding, A. J. Endocrinol. (2000) [Pubmed]
  35. Changes in the fatty acid composition of immune cells and plasma by intravenous injection of dihomo-gamma-linolenic acid in mice. Taki, H., Hamazaki, T., Nakamura, N., Yamashita, N., Kobayashi, M. Prostaglandins Leukot. Essent. Fatty Acids (1995) [Pubmed]
  36. Copper intake affects rat heart performance during ischemia-reperfusion: possible relation to altered lipid and fatty acid metabolism. Cunnane, S.C., McAdoo, K.R., Karmazyn, M. Prostaglandins Leukot. Essent. Fatty Acids (1988) [Pubmed]
  37. Polyunsaturated fatty acid metabolism of human skin fibroblasts during cellular aging. Raederstorff, D., Loechleiter, V., Moser, U. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1995) [Pubmed]
  38. The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism. Horrobin, D.F. Prostaglandins Leukot. Essent. Fatty Acids (1992) [Pubmed]
 
WikiGenes - Universities