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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm.[1]

References

  1. A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Duprey, P., Chowdhury, K., Dressler, G.R., Balling, R., Simon, D., Guenet, J.L., Gruss, P. Genes Dev. (1988) [Pubmed]
 
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