Gene Review:
Cdx1 - caudal type homeobox 1
Mus musculus
Synonyms:
Caudal-type homeobox protein 1, Cdx, Cdx-1, Homeobox protein CDX-1
- The caudal-related homeodomain protein Cdx1 inhibits proliferation of intestinal epithelial cells by down-regulation of D-type cyclins. Lynch, J., Suh, E.R., Silberg, D.G., Rulyak, S., Blanchard, N., Traber, P.G. J. Biol. Chem. (2000)
- Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. Lynch, J., Keller, M., Guo, R.J., Yang, D., Traber, P. Oncogene (2003)
- Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells. Soubeyran, P., Haglund, K., Garcia, S., Barth, B.U., Iovanna, J., Dikic, I. Oncogene (2001)
- Cloning and chromosome assignment of the human CDX2 gene. Drummond, F., Putt, W., Fox, M., Edwards, Y.H. Ann. Hum. Genet. (1997)
- Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Tatematsu, M., Tsukamoto, T., Inada, K. Cancer Sci. (2003)
- Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Subramanian, V., Meyer, B.I., Gruss, P. Cell (1995)
- A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Duprey, P., Chowdhury, K., Dressler, G.R., Balling, R., Simon, D., Guenet, J.L., Gruss, P. Genes Dev. (1988)
- Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Béland, M., Pilon, N., Houle, M., Oh, K., Sylvestre, J.R., Prinos, P., Lohnes, D. Mol. Cell. Biol. (2004)
- The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. Haigis, K., Sage, J., Glickman, J., Shafer, S., Jacks, T. J. Biol. Chem. (2006)
- RARgamma and Cdx1 interactions in vertebral patterning. Allan, D., Houle, M., Bouchard, N., Meyer, B.I., Gruss, P., Lohnes, D. Dev. Biol. (2001)
- Cdx4 is a direct target of the canonical Wnt pathway. Pilon, N., Oh, K., Sylvestre, J.R., Bouchard, N., Savory, J., Lohnes, D. Dev. Biol. (2006)
- Cdx1 and cdx2 expression during intestinal development. Silberg, D.G., Swain, G.P., Suh, E.R., Traber, P.G. Gastroenterology (2000)
- Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. van den Akker, E., Forlani, S., Chawengsaksophak, K., de Graaff, W., Beck, F., Meyer, B.I., Deschamps, J. Development (2002)
- Chicken ovalbumin upstream promoter-transcription factor members repress retinoic acid-induced Cdx1 expression. Béland, M., Lohnes, D. J. Biol. Chem. (2005)
- Functional analysis of cis-regulatory elements controlling initiation and maintenance of early Cdx1 gene expression in the mouse. Lickert, H., Kemler, R. Dev. Dyn. (2002)
- The murine Cdx1 gene product localises to the proliferative compartment in the developing and regenerating intestinal epithelium. Subramanian, V., Meyer, B., Evans, G.S. Differentiation (1998)
- Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Abud, H.E., Watson, N., Heath, J.K. Exp. Cell Res. (2005)
- Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells. Duluc, I., Lorentz, O., Fritsch, C., Leberquier, C., Kedinger, M., Freund, J.N. J. Cell. Sci. (1997)