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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.[1]


  1. yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Semba, K., Nishizawa, M., Miyajima, N., Yoshida, M.C., Sukegawa, J., Yamanashi, Y., Sasaki, M., Yamamoto, T., Toyoshima, K. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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