Gene Review:
FGFR1 - fibroblast growth factor receptor 1
Homo sapiens
Synonyms:
BFGFR, Basic fibroblast growth factor receptor 1, CD331, CEK, FGFBR, ...
- Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Meyers, G.A., Orlow, S.J., Munro, I.R., Przylepa, K.A., Jabs, E.W. Nat. Genet. (1995)
- Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome. González-Martínez, D., Hu, Y., Bouloux, P.M. Frontiers in neuroendocrinology. (2004)
- Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Guasch, G., Popovici, C., Mugneret, F., Chaffanet, M., Pontarotti, P., Birnbaum, D., Pébusque, M.J. Blood (2003)
- Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Reiter, A., Sohal, J., Kulkarni, S., Chase, A., Macdonald, D.H., Aguiar, R.C., Gonçalves, C., Hernandez, J.M., Jennings, B.A., Goldman, J.M., Cross, N.C. Blood (1998)
- Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. Ron, D., Reich, R., Chedid, M., Lengel, C., Cohen, O.E., Chan, A.M., Neufeld, G., Miki, T., Tronick, S.R. J. Biol. Chem. (1993)
- Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Scholpp, S., Groth, C., Lohs, C., Lardelli, M., Brand, M. Dev. Genes Evol. (2004)
- Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Gaughran, F., Payne, J., Sedgwick, P.M., Cotter, D., Berry, M. Brain Res. Bull. (2006)
- MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome. Wan, M., Zhao, K., Lee, S.S., Francke, U. Hum. Mol. Genet. (2001)
- Discovering the role of the major histocompatibility complex in the immune response. McDevitt, H.O. Annu. Rev. Immunol. (2000)
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou, Y., Milne, T.A., Tackett, A.J., Smith, E.R., Fukuda, A., Wysocka, J., Allis, C.D., Chait, B.T., Hess, J.L., Roeder, R.G. Cell (2005)
- Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Tagami, H., Ray-Gallet, D., Almouzni, G., Nakatani, Y. Cell (2004)
- Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Dodé, C., Levilliers, J., Dupont, J.M., De Paepe, A., Le Dû, N., Soussi-Yanicostas, N., Coimbra, R.S., Delmaghani, S., Compain-Nouaille, S., Baverel, F., Pêcheux, C., Le Tessier, D., Cruaud, C., Delpech, M., Speleman, F., Vermeulen, S., Amalfitano, A., Bachelot, Y., Bouchard, P., Cabrol, S., Carel, J.C., Delemarre-van de Waal, H., Goulet-Salmon, B., Kottler, M.L., Richard, O., Sanchez-Franco, F., Saura, R., Young, J., Petit, C., Hardelin, J.P. Nat. Genet. (2003)
- Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M. Cell (2000)
- Acidic fibroblast growth factor (FGF-1) and FGF receptor 1 signaling in human Y79 retinoblastoma. Siffroi-Fernandez, S., Cinaroglu, A., Fuhrmann-Panfalone, V., Normand, G., Bugra, K., Sahel, J., Hicks, D. Arch. Ophthalmol. (2005)
- Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. González-Martínez, D., Kim, S.H., Hu, Y., Guimond, S., Schofield, J., Winyard, P., Vannelli, G.B., Turnbull, J., Bouloux, P.M. J. Neurosci. (2004)
- Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro. Volm, M., Koomägi, R., Mattern, J., Stammler, G. Anticancer Res. (1997)
- FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas. Reis-Filho, J.S., Simpson, P.T., Turner, N.C., Lambros, M.B., Jones, C., Mackay, A., Grigoriadis, A., Sarrio, D., Savage, K., Dexter, T., Iravani, M., Fenwick, K., Weber, B., Hardisson, D., Schmitt, F.C., Palacios, J., Lakhani, S.R., Ashworth, A. Clin. Cancer Res. (2006)
- Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Gu, T.L., Goss, V.L., Reeves, C., Popova, L., Nardone, J., Macneill, J., Walters, D.K., Wang, Y., Rush, J., Comb, M.J., Druker, B.J., Polakiewicz, R.D. Blood (2006)
- Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains. Yokote, H., Fujita, K., Jing, X., Sawada, T., Liang, S., Yao, L., Yan, X., Zhang, Y., Schlessinger, J., Sakaguchi, K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Popovici, C., Zhang, B., Grégoire, M.J., Jonveaux, P., Lafage-Pochitaloff, M., Birnbaum, D., Pébusque, M.J. Blood (1999)
- Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. Murgue, B., Tsunekawa, S., Rosenberg, I., deBeaumont, M., Podolsky, D.K. Cancer Res. (1994)
- Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration--lessons from in vivo studies in mice and rats. Grothe, C., Haastert, K., Jungnickel, J. Brain Res. Brain Res. Rev. (2006)
- Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. Zhao, X.M., Frist, W.H., Yeoh, T.K., Miller, G.G. J. Clin. Invest. (1994)
- Chimeras of the native form or achondroplasia mutant (G375C) of human fibroblast growth factor receptor 3 induce ligand-dependent differentiation of PC12 cells. Thompson, L.M., Raffioni, S., Wasmuth, J.J., Bradshaw, R.A. Mol. Cell. Biol. (1997)
- Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase. Kan, M., Wu, X., Wang, F., McKeehan, W.L. J. Biol. Chem. (1999)
- Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Hart, K.C., Robertson, S.C., Kanemitsu, M.Y., Meyer, A.N., Tynan, J.A., Donoghue, D.J. Oncogene (2000)
- Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly. Ibrahimi, O.A., Zhang, F., Hrstka, S.C., Mohammadi, M., Linhardt, R.J. Biochemistry (2004)
- Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells. Alizadeh, M., Wada, M., Gelfman, C.M., Handa, J.T., Hjelmeland, L.M. Invest. Ophthalmol. Vis. Sci. (2001)
- Comparative localization of fibroblast growth factor receptor-1, -2, and -3 mRNAs in the rat brain: in situ hybridization analysis. Belluardo, N., Wu, G., Mudo, G., Hansson, A.C., Pettersson, R., Fuxe, K. J. Comp. Neurol. (1997)
- FGFR1 and WT1 are markers of human prostate cancer progression. Devilard, E., Bladou, F., Ramuz, O., Karsenty, G., Dal??s, J.P., Gravis, G., Nguyen, C., Bertucci, F., Xerri, L., Birnbaum, D. BMC Cancer (2006)
- MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands. McLeskey, S.W., Ding, I.Y., Lippman, M.E., Kern, F.G. Cancer Res. (1994)
- Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Zhang, J., Zhang, L., Su, X., Li, M., Xie, L., Malchers, F., Fan, S., Yin, X., Xu, Y., Liu, K., Dong, Z., Zhu, G., Qian, Z., Tang, L., Schöttle, J., Zhan, P., Ji, Q., Kilgour, E., Smith, P.D., Brooks, A.N., Thomas, R.K., Gavine, P.R. Clin. Cancer Res. (2012)
- Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56. Kos, F.J., Chin, C.S. Immunol. Cell Biol. (2002)
- Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action. Stachowiak, M.K., Maher, P.A., Joy, A., Mordechai, E., Stachowiak, E.K. Brain Res. Mol. Brain Res. (1996)
- FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. Yan, K.S., Kuti, M., Yan, S., Mujtaba, S., Farooq, A., Goldfarb, M.P., Zhou, M.M. J. Biol. Chem. (2002)
- Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Ruta, M., Burgess, W., Givol, D., Epstein, J., Neiger, N., Kaplow, J., Crumley, G., Dionne, C., Jaye, M., Schlessinger, J. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. Fang, X., Stachowiak, E.K., Dunham-Ems, S.M., Klejbor, I., Stachowiak, M.K. J. Biol. Chem. (2005)
- p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. Li, F., Adam, L., Vadlamudi, R.K., Zhou, H., Sen, S., Chernoff, J., Mandal, M., Kumar, R. EMBO Rep. (2002)
- Phosphorylation of histones by tissue transglutaminase. Mishra, S., Saleh, A., Espino, P.S., Davie, J.R., Murphy, L.J. J. Biol. Chem. (2006)
- The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activation. Deng, Z., Chen, C.J., Chamberlin, M., Lu, F., Blobel, G.A., Speicher, D., Cirillo, L.A., Zaret, K.S., Lieberman, P.M. Mol. Cell. Biol. (2003)
- Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors. Haugsten, E.M., Sørensen, V., Brech, A., Olsnes, S., Wesche, J. J. Cell. Sci. (2005)
- Cytotoxic activity of a diptheria toxin/FGF6 mitotoxin on human tumour cell lines. Coll-Fresno, P.M., Batoz, M., Tarquin, S., Birnbaum, D., Coulier, F. Oncogene (1997)
- Fibroblast growth factor expression in the postnatal growth plate. Lazarus, J.E., Hegde, A., Andrade, A.C., Nilsson, O., Baron, J. Bone (2007)
- Fibroblast growth factors and their receptors in parathyroid disease. Lambert, D., Eaton, C.L., Harrison, B.J. World journal of surgery. (1998)
- Cell- and receptor isotype-specific phosphorylation of SNT1 by fibroblast growth factor receptor tyrosine kinases. Wang, F. In Vitro Cell. Dev. Biol. Anim. (2002)
- Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. Vainikka, S., Partanen, J., Bellosta, P., Coulier, F., Birnbaum, D., Basilico, C., Jaye, M., Alitalo, K. EMBO J. (1992)
- Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells. Raffioni, S., Thomas, D., Foehr, E.D., Thompson, L.M., Bradshaw, R.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Mutations causing achondroplasia and thanatophoric dysplasia alter bFGF-induced calcium signals in human diploid fibroblasts. Nguyen, H.B., Estacion, M., Gargus, J.J. Hum. Mol. Genet. (1997)
- Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity. Chellaiah, A., Yuan, W., Chellaiah, M., Ornitz, D.M. J. Biol. Chem. (1999)
- Nuclear accumulation of fibroblast growth factor receptors in human glial cells--association with cell proliferation. Stachowiak, E.K., Maher, P.A., Tucholski, J., Mordechai, E., Joy, A., Moffett, J., Coons, S., Stachowiak, M.K. Oncogene (1997)