Gene Review:
FYN - FYN proto-oncogene, Src family tyrosine...
Homo sapiens
Synonyms:
MGC45350, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, SYN, ...
Kumar,
Meizel,
Löwenberg,
Verhaar,
Bilderbeek,
Marle,
Buttgereit,
Peppelenbosch,
van Deventer,
Hommes,
Marie-Cardine,
Verhagen,
Eckerskorn,
Schraven,
Cybulsky,
Takano,
Papillon,
Hao,
Mancini,
Di Battista,
Cybulsky,
Curtis,
Jane,
Hilton,
Dougherty,
Bodine,
Begley,
Moore,
Masliah,
Rippeth,
Gonzalez,
Carey,
Cherner,
Ellis,
Achim,
Marcotte,
Heaton,
Grant,
- Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Berwanger, B., Hartmann, O., Bergmann, E., Bernard, S., Nielsen, D., Krause, M., Kartal, A., Flynn, D., Wiedemeyer, R., Schwab, M., Schäfer, H., Christiansen, H., Eilers, M. Cancer Cell (2002)
- Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role. Ho, G.J., Hashimoto, M., Adame, A., Izu, M., Alford, M.F., Thal, L.J., Hansen, L.A., Masliah, E. Neurobiol. Aging (2005)
- Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells. Horak, I.D., Kawakami, T., Gregory, F., Robbins, K.C., Bolen, J.B. J. Virol. (1989)
- Myristoyl CoA:protein N-myristoyltransferase activities from rat liver and yeast possess overlapping yet distinct peptide substrate specificities. Towler, D.A., Adams, S.P., Eubanks, S.R., Towery, D.S., Jackson-Machelski, E., Glaser, L., Gordon, J.I. J. Biol. Chem. (1988)
- The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression. Cybulsky, A.V., Takano, T., Papillon, J., Hao, W., Mancini, A., Di Battista, J.A., Cybulsky, M.I. Am. J. Physiol. Renal Physiol. (2007)
- Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Lunardi-Iskandar, Y., Bryant, J.L., Zeman, R.A., Lam, V.H., Samaniego, F., Besnier, J.M., Hermans, P., Thierry, A.R., Gill, P., Gallo, R.C. Nature (1995)
- Sympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt. Mosqueda-Garcia, R., Furlan, R., Fernandez-Violante, R., Desai, T., Snell, M., Jarai, Z., Ananthram, V., Robertson, R.M., Robertson, D. J. Clin. Invest. (1997)
- Transfection of an Fc gamma receptor cDNA induces T cells to become phagocytic. Hunter, S., Kamoun, M., Schreiber, A.D. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Acquisition of transforming properties by FYN, a normal SRC-related human gene. Kawakami, T., Kawakami, Y., Aaronson, S.A., Robbins, K.C. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Invasion of human epithelial cells by Pseudomonas aeruginosa involves src-like tyrosine kinases p60Src and p59Fyn. Esen, M., Grassmé, H., Riethmüller, J., Riehle, A., Fassbender, K., Gulbins, E. Infect. Immun. (2001)
- The effects of macrolide and quinolone antibiotics in methicillin-resistant Staphylococcus aureus biofilm growth. Dasgupta, M.K., Shishido, H., Salama, S., Singh, R., Larabie, M., Micetich, R.G. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. (1997)
- Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells. Mills, G.B., Arima, N., May, C., Hill, M., Schmandt, R., Li, J., Miyamoto, N.G., Greene, W.C. Int. Immunol. (1992)
- yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Semba, K., Nishizawa, M., Miyajima, N., Yoshida, M.C., Sukegawa, J., Yamanashi, Y., Sasaki, M., Yamamoto, T., Toyoshima, K. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes. Ricci, J.E., Maulon, L., Luciano, F., Guerin, S., Livolsi, A., Mari, B., Breittmayer, J.P., Peyron, J.F., Auberger, P. Oncogene (1999)
- Possible role of tyrosine kinase activity in interleukin 4-induced expression of germ-line C epsilon transcripts in a human Burkitt lymphoma B-cell line, DND39. Ikizawa, K., Kajiwara, K., Koshio, T., Yanagihara, Y. J. Allergy Clin. Immunol. (1994)
- Nocodazole inhibits signal transduction by the T cell antigen receptor. Huby, R.D., Weiss, A., Ley, S.C. J. Biol. Chem. (1998)
- Nicotinic acetylcholine receptor subunits and associated proteins in human sperm. Kumar, P., Meizel, S. J. Biol. Chem. (2005)
- Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Curtis, D.J., Jane, S.M., Hilton, D.J., Dougherty, L., Bodine, D.M., Begley, C.G. Exp. Hematol. (2000)
- The solution structure of the intramolecular photoproduct of d(TpA) derived with the use of NMR and a combination of distance geometry and molecular dynamics. Koning, T.M., Davies, R.J., Kaptein, R. Nucleic Acids Res. (1990)
- Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. L??wenberg, M., Verhaar, A.P., Bilderbeek, J., Marle, J., Buttgereit, F., Peppelenbosch, M.P., van Deventer, S.J., Hommes, D.W. EMBO Rep. (2006)
- Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines. Hallek, M., Neumann, C., Schäffer, M., Danhauser-Riedl, S., von Bubnoff, N., de Vos, G., Druker, B.J., Yasukawa, K., Griffin, J.D., Emmerich, B. Exp. Hematol. (1997)
- The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21. Jackson, A., Panayiotidis, P., Foroni, L. Genomics (1998)
- Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. Moore, D.J., Masliah, E., Rippeth, J.D., Gonzalez, R., Carey, C.L., Cherner, M., Ellis, R.J., Achim, C.L., Marcotte, T.D., Heaton, R.K., Grant, I. AIDS (2006)
- SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. Marie-Cardine, A., Verhagen, A.M., Eckerskorn, C., Schraven, B. FEBS Lett. (1998)
- Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. Price, D.J., Rivnay, B., Fu, Y., Jiang, S., Avraham, S., Avraham, H. J. Biol. Chem. (1997)
- Tyrosine phosphorylation in early embryonic growth cones. Bixby, J.L., Jhabvala, P. J. Neurosci. (1993)
- Neuron-specific splicing of C-SRC RNA in human brain. Pyper, J.M., Bolen, J.B. J. Neurosci. Res. (1989)
- Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains. Bardelli, A., Maina, F., Gout, I., Fry, M.J., Waterfield, M.D., Comoglio, P.M., Ponzetto, C. Oncogene (1992)
- Detection of low numbers of neuroblastoma cells in vitro. Lai, P.S., Chee, S., Chiu, L.L., Sano, K. Ann. Acad. Med. Singap. (1997)