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Gene Review

LTK  -  leukocyte receptor tyrosine kinase

Homo sapiens

Synonyms: Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, TYK1
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Disease relevance of LTK


Psychiatry related information on LTK


High impact information on LTK


Chemical compound and disease context of LTK


Biological context of LTK


Anatomical context of LTK


Associations of LTK with chemical compounds


Physical interactions of LTK


Enzymatic interactions of LTK


Regulatory relationships of LTK


Other interactions of LTK


Analytical, diagnostic and therapeutic context of LTK


  1. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Morris, S.W., Naeve, C., Mathew, P., James, P.L., Kirstein, M.N., Cui, X., Witte, D.P. Oncogene (1997) [Pubmed]
  2. Protein tyrosine kinase activity is essential for Fc gamma receptor-mediated intracellular killing of Staphylococcus aureus by human monocytes. Zheng, L., Nibbering, P.H., Zomerdijk, T.P., van Furth, R. Infect. Immun. (1994) [Pubmed]
  3. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Carpino, N., Wisniewski, D., Strife, A., Marshak, D., Kobayashi, R., Stillman, B., Clarkson, B. Cell (1997) [Pubmed]
  4. The tyrosine phosphorylation substrate p36 is developmentally regulated in embryonic avian limb and is induced in cell culture. Carter, C., Howlett, A.R., Martin, G.S., Bissell, M.J. J. Cell Biol. (1986) [Pubmed]
  5. Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein. Melamed, I., Wang, G., Roifman, C.M. J. Immunol. (1992) [Pubmed]
  6. Altered protein tyrosine phosphorylation in Alzheimer's disease. Shapiro, I.P., Masliah, E., Saitoh, T. J. Neurochem. (1991) [Pubmed]
  7. Src tyrosine kinase is a novel direct effector of G proteins. Ma, Y.C., Huang, J., Ali, S., Lowry, W., Huang, X.Y. Cell (2000) [Pubmed]
  8. T cell activation by clustered tyrosine kinases. Kolanus, W., Romeo, C., Seed, B. Cell (1993) [Pubmed]
  9. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Velazquez, L., Fellous, M., Stark, G.R., Pellegrini, S. Cell (1992) [Pubmed]
  10. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Chan, A.C., Iwashima, M., Turck, C.W., Weiss, A. Cell (1992) [Pubmed]
  11. Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cooke, M.P., Abraham, K.M., Forbush, K.A., Perlmutter, R.M. Cell (1991) [Pubmed]
  12. Replication of hepatitis B virus in transfected nonhepatic cells. Seifer, M., Heermann, K.H., Gerlich, W.H. Virology (1990) [Pubmed]
  13. Noncontact holmium:YAG laser thermal keratoplasty to correct hyperopia: 18-month follow-up. Kohnen, T., Koch, D.D., McDonnell, P.J., Menefee, R.F., Berry, M.J. Ophthalmologica (1997) [Pubmed]
  14. Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Baker, C.H., Solorzano, C.C., Fidler, I.J. Cancer Res. (2002) [Pubmed]
  15. Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes. Juszczak, R.J., Turchin, H., Truneh, A., Culp, J., Kassis, S. J. Biol. Chem. (1991) [Pubmed]
  16. Binding of FimD on Bordetella pertussis to very late antigen-5 on monocytes activates complement receptor type 3 via protein tyrosine kinases. Hazenbos, W.L., van den Berg, B.M., Geuijen, C.W., Mooi, F.R., van Furth, R. J. Immunol. (1995) [Pubmed]
  17. Identification and chromosomal mapping of new human tyrosine kinase genes. Krolewski, J.J., Lee, R., Eddy, R., Shows, T.B., Dalla-Favera, R. Oncogene (1990) [Pubmed]
  18. Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. Kozutsumi, H., Toyoshima, H., Hagiwara, K., Yazaki, Y., Hirai, H. Oncogene (1994) [Pubmed]
  19. Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. Toyoshima, H., Kozutsumi, H., Maru, Y., Hagiwara, K., Furuya, A., Mioh, H., Hanai, N., Takaku, F., Yazaki, Y., Hirai, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  20. Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. Ueno, H., Sasaki, K., Kozutsumi, H., Miyagawa, K., Mitani, K., Yazaki, Y., Hirai, H. J. Biol. Chem. (1996) [Pubmed]
  21. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Weiss, A., Koretzky, G., Schatzman, R.C., Kadlecek, T. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  22. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Li, N., Nakamura, K., Jiang, Y., Tsurui, H., Matsuoka, S., Abe, M., Ohtsuji, M., Nishimura, H., Kato, K., Kawai, T., Atsumi, T., Koike, T., Shirai, T., Ueno, H., Hirose, S. Hum. Mol. Genet. (2004) [Pubmed]
  23. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Müller, M., Briscoe, J., Laxton, C., Guschin, D., Ziemiecki, A., Silvennoinen, O., Harpur, A.G., Barbieri, G., Witthuhn, B.A., Schindler, C. Nature (1993) [Pubmed]
  24. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Mukhopadhyay, D., Tsiokas, L., Zhou, X.M., Foster, D., Brugge, J.S., Sukhatme, V.P. Nature (1995) [Pubmed]
  25. Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. Ting, A.T., Karnitz, L.M., Schoon, R.A., Abraham, R.T., Leibson, P.J. J. Exp. Med. (1992) [Pubmed]
  26. Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. Yohannan, J., Wienands, J., Coggeshall, K.M., Justement, L.B. J. Biol. Chem. (1999) [Pubmed]
  27. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Wai, D.H., Knezevich, S.R., Lucas, T., Jansen, B., Kay, R.J., Sorensen, P.H. Oncogene (2000) [Pubmed]
  28. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Barber, E.K., Dasgupta, J.D., Schlossman, S.F., Trevillyan, J.M., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS. Maru, Y., Peters, K.L., Afar, D.E., Shibuya, M., Witte, O.N., Smithgall, T.E. Mol. Cell. Biol. (1995) [Pubmed]
  30. The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Raab, M., Yamamoto, M., Rudd, C.E. Mol. Cell. Biol. (1994) [Pubmed]
  31. Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src. Lee, H.J., Kim, S., Pelletier, J., Kim, J. FEBS Lett. (2004) [Pubmed]
  32. Separation and characterization of a phosphatidylinositol kinase activity that co-purifies with the epidermal growth factor receptor. Thompson, D.M., Cochet, C., Chambaz, E.M., Gill, G.N. J. Biol. Chem. (1985) [Pubmed]
  33. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. Torres, E., Rosen, M.K. J. Biol. Chem. (2006) [Pubmed]
  34. Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. Hutchcroft, J.E., Harrison, M.L., Geahlen, R.L. J. Biol. Chem. (1992) [Pubmed]
  35. Clustering of the platelet Fc gamma receptor induces noncovalent association with the tyrosine kinase p72syk. Chacko, G.W., Duchemin, A.M., Coggeshall, K.M., Osborne, J.M., Brandt, J.T., Anderson, C.L. J. Biol. Chem. (1994) [Pubmed]
  36. The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family. Pawson, T., Letwin, K., Lee, T., Hao, Q.L., Heisterkamp, N., Groffen, J. Mol. Cell. Biol. (1989) [Pubmed]
  37. Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells. Kiang, J.G., Ding, X.Z., Gist, I.D., Jones, R.R., Tsokos, G.C. Eur. J. Pharmacol. (1998) [Pubmed]
  38. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Paz, P.E., Wang, S., Clarke, H., Lu, X., Stokoe, D., Abo, A. Biochem. J. (2001) [Pubmed]
  39. Modulation of integrin function in hematopoietic progenitor cells by CD43 engagement: possible involvement of protein tyrosine kinase and phospholipase C-gamma. Anzai, N., Gotoh, A., Shibayama, H., Broxmeyer, H.E. Blood (1999) [Pubmed]
  40. CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells. Sancho, J., Ledbetter, J.A., Choi, M.S., Kanner, S.B., Deans, J.P., Terhorst, C. J. Biol. Chem. (1992) [Pubmed]
  41. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Iwahara, T., Fujimoto, J., Wen, D., Cupples, R., Bucay, N., Arakawa, T., Mori, S., Ratzkin, B., Yamamoto, T. Oncogene (1997) [Pubmed]
  42. Mutational analysis of the epidermal growth factor-receptor kinase. Schlessinger, J. Biochem. Soc. Symp. (1990) [Pubmed]
  43. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Morris, S.W., Kirstein, M.N., Valentine, M.B., Dittmer, K.G., Shapiro, D.N., Saltman, D.L., Look, A.T. Science (1994) [Pubmed]
  44. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. Guschin, D., Rogers, N., Briscoe, J., Witthuhn, B., Watling, D., Horn, F., Pellegrini, S., Yasukawa, K., Heinrich, P., Stark, G.R. EMBO J. (1995) [Pubmed]
  45. Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor. Weber, J.R., Bell, G.M., Han, M.Y., Pawson, T., Imboden, J.B. J. Exp. Med. (1992) [Pubmed]
  46. Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel factor to stimulate proliferation of the human factor-dependent cell line, M07e. Miyazawa, K., Hendrie, P.C., Kim, Y.J., Mantel, C., Yang, Y.C., Kwon, B.S., Broxmeyer, H.E. Blood (1992) [Pubmed]
  47. Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas. Kolenko, V., Wang, Q., Riedy, M.C., O'Shea, J., Ritz, J., Cathcart, M.K., Rayman, P., Tubbs, R., Edinger, M., Novick, A., Bukowski, R., Finke, J. J. Immunol. (1997) [Pubmed]
  48. Non random activation of endogenous interleukin-2, (IL-2), IL-2 receptor alpha and IL-2 receptor beta genes after transfection of mouse fibroblasts with a cDNA for the alpha chain of the human IL-2 receptor. Han, D., Plaisance, S., Rubinstein, E., Alileche, A., Pottin-Clemenceau, C., Kim, T.S., Cohen, E.P., Jasmin, C., Azzarone, B. Eur. J. Immunol. (1995) [Pubmed]
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