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Gene Review

YES1  -  YES proto-oncogene 1, Src family tyrosine...

Homo sapiens

Synonyms: HsT441, P61-YES, Proto-oncogene c-Yes, Tyrosine-protein kinase Yes, YES, ...


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Disease relevance of YES1


High impact information on YES1

  • Here we investigate the solution structure of the WW domain of human YAP65 (for Yes kinase-associated protein) in complex with proline-rich peptides containing the core motif PPxY [6].
  • Location of the c-yes gene on the human chromosome and its expression in various tissues [7].
  • The transcriptional coactivator Yes-associated protein (YAP) drives p73 gene-target specificity in response to DNA Damage [8].
  • Tacrolimus for active ulcerative colitis? Yes! (Even though cochrane says "no") [9].
  • Src family of tyrosine kinases: a role of c-yes in colon carcinogenesis [10]?

Chemical compound and disease context of YES1


Biological context of YES1


Anatomical context of YES1


Associations of YES1 with chemical compounds

  • Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets [20].
  • Finally, c-Yes immunoprecipitated from epithelial cells is able to phosphorylate the wild-type Cyt2 tail but not the mutant derivative in which tyrosine 354 has been substituted with alanine [17].
  • A constitutively active form of c-Yes was observed to decrease the binding affinity between YAP and p53BP-2 using chloramphenicol acetyltransferase/enzyme-linked immunosorbent assay, whereas the overexpression of c-Yes did not modify this interaction [21].
  • Mutation of the tyrosine autophosphorylation site of Yes to a phenylalanine resulted in a mutant Yes enzyme that can be fully inactivated by a sub-stoichiometric amount of Csk in a time-dependent manner [22].
  • These results suggest that cAMP activates while Ca(2+) inhibits human sperm c-yes kinase activity [23].

Physical interactions of YES1


Co-localisations of YES1


Other interactions of YES1

  • In addition, we show that the nonreceptor tyrosine kinase c-Yes is contained within EBP50 protein complexes by association with YAP65 [16].
  • We have found that two different regions of QM protein were associated with the SH3 domain of c-Yes [25].
  • Taken together, these results suggest that YES1, TYMS, HEC and TGIF are likely to be candidate targets for 18p11.3 amplification and be associated with esophageal tumorigenesis [26].
  • Only four known genes, YES1, TYMS, HEC and TGIF showed amplification and consequent over-expression [26].
  • We report here the map location of a Xiphophorus yes gene, YES1, in LG VI, closest to the EGFR gene and the assignment of a fyn gene homologue to newly designated LG XV, linked to the gene for cytosolic alpha-galactosidase [27].

Analytical, diagnostic and therapeutic context of YES1


  1. c-Yes response to growth factor activation. Clump, D.A., Qazi, I.H., Sudol, M., Flynn, D.C. Growth Factors (2005) [Pubmed]
  2. Elevated expression of protein tyrosine kinase c-Yes, but not c-Src, in human malignant melanoma. Loganzo, F., Dosik, J.S., Zhao, Y., Vidal, M.J., Nanus, D.M., Sudol, M., Albino, A.P. Oncogene (1993) [Pubmed]
  3. The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells. Sommer, S., Cui, Y., Brewer, G., Fuqua, S.A. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  4. The Src family kinase c-Yes is required for maturation of West Nile virus particles. Hirsch, A.J., Medigeshi, G.R., Meyers, H.L., DeFilippis, V., Früh, K., Briese, T., Lipkin, W.I., Nelson, J.A. J. Virol. (2005) [Pubmed]
  5. Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Han, N.M., Fleming, R.Y., Curley, S.A., Gallick, G.E. Ann. Surg. Oncol. (1997) [Pubmed]
  6. Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Macias, M.J., Hyvönen, M., Baraldi, E., Schultz, J., Sudol, M., Saraste, M., Oschkinat, H. Nature (1996) [Pubmed]
  7. Location of the c-yes gene on the human chromosome and its expression in various tissues. Semba, K., Yamanashi, Y., Nishizawa, M., Sukegawa, J., Yoshida, M., Sasaki, M., Yamamoto, T., Toyoshima, K. Science (1985) [Pubmed]
  8. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Strano, S., Monti, O., Pediconi, N., Baccarini, A., Fontemaggi, G., Lapi, E., Mantovani, F., Damalas, A., Citro, G., Sacchi, A., Del Sal, G., Levrero, M., Blandino, G. Mol. Cell (2005) [Pubmed]
  9. Tacrolimus for active ulcerative colitis? Yes! (Even though cochrane says "no"). Ullman, T.A. Gastroenterology (2007) [Pubmed]
  10. Src family of tyrosine kinases: a role of c-yes in colon carcinogenesis? Boardman, L.A., Karnes, W.E. Gastroenterology (1995) [Pubmed]
  11. Is there still a role for intravenous heparin in acute stroke? Yes. Grau, A.J., Hacke, W. Arch. Neurol. (1999) [Pubmed]
  12. Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and hypertension: does it matter? Yes. Klatsky, A.L. Journal of cardiovascular risk. (2003) [Pubmed]
  13. D-penicillamine in systemic sclerosis? Yes! Medsger, T.A., Lucas, M., Wildy, K.S., Baker, C. Scand. J. Rheumatol. (2001) [Pubmed]
  14. Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors. Wang, W., Marsh, S., Cassidy, J., McLeod, H.L. Cancer Res. (2001) [Pubmed]
  15. Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18. Silverman, G.A., Kuo, W.L., Taillon-Miller, P., Gray, J.W. Genomics (1993) [Pubmed]
  16. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. Mohler, P.J., Kreda, S.M., Boucher, R.C., Sudol, M., Stutts, M.J., Milgram, S.L. J. Cell Biol. (1999) [Pubmed]
  17. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. Lee, S.W., Bonnah, R.A., Higashi, D.L., Atkinson, J.P., Milgram, S.L., So, M. J. Cell Biol. (2002) [Pubmed]
  18. Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation. Zhao, Y., Sudol, M., Hanafusa, H., Krueger, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  19. Characterization of cDNA clones for the human c-yes gene. Sukegawa, J., Semba, K., Yamanashi, Y., Nishizawa, M., Miyajima, N., Yamamoto, T., Toyoshima, K. Mol. Cell. Biol. (1987) [Pubmed]
  20. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Huang, M.M., Bolen, J.B., Barnwell, J.W., Shattil, S.J., Brugge, J.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  21. Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. Espanel, X., Sudol, M. J. Biol. Chem. (2001) [Pubmed]
  22. Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. Sun, G., Sharma, A.K., Budde, R.J. Oncogene (1998) [Pubmed]
  23. Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3',5'-monophosphate and inhibition by Ca(2+). Leclerc, P., Goupil, S. Biol. Reprod. (2002) [Pubmed]
  24. Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Chen, Y.H., Lu, Q., Goodenough, D.A., Jeansonne, B. Mol. Biol. Cell (2002) [Pubmed]
  25. QM, a putative tumor suppressor, regulates proto-oncogene c-yes. Oh, H.S., Kwon, H., Sun, S.K., Yang, C.H. J. Biol. Chem. (2002) [Pubmed]
  26. Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas. Nakakuki, K., Imoto, I., Pimkhaokham, A., Fukuda, Y., Shimada, Y., Imamura, M., Amagasa, T., Inazawa, J. Carcinogenesis (2002) [Pubmed]
  27. Mapping of tyrosine kinase gene family members in a Xiphophorus melanoma model. Morizot, D.C., McEntire, B.B., Della Coletta, L., Kazianis, S., Schartl, M., Nairn, R.S. Mol. Carcinog. (1998) [Pubmed]
  28. Expression of cellular-yes protein in mammalian tissues. Zhao, Y.H., Krueger, J.G., Sudol, M. Oncogene (1990) [Pubmed]
  29. Angiotensin II controls p21ras activity via pp60c-src. Schieffer, B., Paxton, W.G., Chai, Q., Marrero, M.B., Bernstein, K.E. J. Biol. Chem. (1996) [Pubmed]
  30. Expression of Src family kinases and their putative substrates in the human preosteoclastic cell line FLG 29.1. Jeschke, M., Brandi, M.L., Susa, M. J. Bone Miner. Res. (1998) [Pubmed]
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