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Watanabe, T. et al.

Mutagenic effects of cadmium on mammalian oocyte chromosomes.

When female golden hamsters were treated with cadmium chloride at the oogenesis stages of diakinesis/metaphase I to metaphase II, oocytes with the chromosomal complements of hyperhaploidy and diploidy, as well as oocytes at the anaphase-I stage, were observed. Oocytes of this species were especially sensitive to cadmium. Chromosome analysis of metaphase-II oocytes seems to be a useful method for the screening of mutagenicity of environmental contaminants in mammalian germ cells in vivo.[1]

References

Mutagenic effects of cadmium on mammalian oocyte chromosomes. Watanabe, T., Shimada, T., Endo, A. Mutat. Res. (1979) [Pubmed]

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