Mutants of Bacillus megaterium resistant to uncouplers of oxidative phosphorylation.
Mutants of Bacillus megaterium displaying malate-stimulated ATP synthesis resistant to uncouplers of oxidative phosphorylation were isolated and partially characterized. ATP synthesis in such mutants was resistant to carbonyl cyanide m-chlorophenyl hydrazone as well as to other uncouplers including 2,4-dinitrophenol, pentachlorophenol, and sodium azide. ATP synthesis in the wild type and in resistant mutants was sensitive to N,N'-dicyclohexylcarbodiimide, tributyltin, valinomycin plus potassium, and potassium cyanide. Active transport of glycine and glutamine which are sensitive to uncouplers in the wild type was also uncoupler-sensitive in the mutants.[1]References
- Mutants of Bacillus megaterium resistant to uncouplers of oxidative phosphorylation. Decker, S.J., Lang, D.R. J. Biol. Chem. (1977) [Pubmed]
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