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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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De novo X-chromosome inactivation in somatic hybrid cells between the XO mouse embryonal carcinoma cell and XY rat lymphocyte.

Polyethylene glycol-mediated cell fusion between the hypoxanthine phosphoribosyl transferase (HPRT) deficient XO mouse embryonal carcinoma cell line, PSA-6TG1, and thymus or spleen lymphocytes from the normal male WKA/Hok rat gave rise to 35 somatic hybrid cultures. Hybrid cells being products of either a 1 : 1 or a 2 : 1 fusion invariably had morphological characteristics of endodermal cells from early embryos. BrdU-acridine orange (AO) fluorescence microscopy revealed do novo appearance of a late or early replicating, presumably genetically inactivated, mouse X chromosome in a substantial proportion of virtually tetraploid (XXY) or hexaploid (XXXY) hybrid cells.[1]

References

  1. De novo X-chromosome inactivation in somatic hybrid cells between the XO mouse embryonal carcinoma cell and XY rat lymphocyte. Takagi, N. Exp. Cell Res. (1983) [Pubmed]
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