Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Moore, C.E. et al.

Positional specificity of trans fatty acids in fetal lecithin.

Differences in the positional incorporation of 9-trans[1-(14)C] octadecenoic (elaidic) and 9-trans,12-trans[1-(14)C] octadecadienoic (linoelaidic) acids in fetal lecithin of rats were demonstrated. On the 20th day of gestation, a 14C-labeled albumin complex of elaidic or linoelaidic acid was injected into the jugular vein of pregnant rats. For comparative purposes, 9-cis[1-(14)C] octadecenoic (oleic) or 9-cis,12-cis[1-(14)C] octadecadienoic (linoleic acid) was injected into the maternal circulation of rats. Animals were killed 6 hr later. Distribution of label in total lipids and phospholipids (PL) of fetal issue was measured by TLC. Irrespective of the label, the highest percentage of total radioactivity was associated with PL-59 to 67%. Within PL, the major portion of radioactivity was found in choline phosphoglycerides (CPG)-53 to 67%, and in ethanolamine phosphoglycerides (EPG)-18 to 33%. While linoelaidic acid was predominantly esterified in the 2-position of CPG, elaidic acid was nearly equally distributed between positions 1 and 2 of lecithin. Distribution of radioactivity within fatty acid methyl esters (FAME) of CPG measured by radio-GLC suggested that oleic and possibly linoleic acids may be converted to nervonic and arachidonic acid, respectively, in the rat by the 20th day of gestation. Following injection of elaidate, radioacivity of FAME was distributed between palmitate and elaidic acid indicating that rat fetal tissue may metabolize elaidic acid via beta-oxidation. In contrast, following injection of linoelaidate, radioactivity of FAME was primarily associated with tt-18:2, suggesting little biotransformation to other fatty acids by fetal tissues.[1]

References

Positional specificity of trans fatty acids in fetal lecithin. Moore, C.E., Dhopeshwarkar, G.A. Lipids (1981) [Pubmed]

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