- Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Harlan, D.M., Hengartner, H., Huang, M.L., Kang, Y.H., Abe, R., Moreadith, R.W., Pircher, H., Gray, G.S., Ohashi, P.S., Freeman, G.J. Proc. Natl. Acad. Sci. U.S.A. (1994)