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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern.

In a search for mutations affecting embryonic muscle development in Drosophila we identified a mutation caused by the insertion of a P-element, which we called not enough muscles (nem). The phenotype of the P-element mutation of the nem gene suggests that it may be required for the development of the somatic musculature and the chordotonal organs of the PNS, while it is not involved in the development of the visceral mesoderm and the dorsal vessel. Mutant embryos are characterized by partial absence of muscles, monitored by immunostainings with mesoderm-specific anti-beta 3 tubulin and anti-myosin heavy chain antibodies. Besides these muscle distortions, defects in the peripheral nervous system were found, indicating a dual function of the nem gene product. Ethyl methane sulfonate-induced alleles for the P-element mutation were created for a detailed analysis. One of these alleles is characterized by unfused myoblasts which express beta 3 tubulin and myosin heavy chain, indicating the state of cell differentiation.[1]


  1. The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern. Burchard, S., Paululat, A., Hinz, U., Renkawitz-Pohl, R. J. Cell. Sci. (1995) [Pubmed]
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