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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cloning and expression of a cDNA for rat prostacyclin receptor.

A cDNA clone for rat prostacyclin receptor was isolated. The cDNA encodes a protein of 416 amino acid residues (M(r) 44,662) with putative seven transmembrane domains, and belongs to the G protein-coupled receptor superfamily. Specific binding of [3H]iloprost was found in membrane of COS-7 cells transfected with the cDNA (Kd = 1.3 nM) and was displaced with unlabeled prostaglandins in the order of iloprost = cicaprost > PGE1 > STA2 = PGE2 = PGD2 > PGF2 alpha. Northern blot analysis demonstrated that rat prostacyclin receptor mRNA is expressed in the lung, spleen, heart, pancreas, thymus, stomach and aorta.[1]


  1. Cloning and expression of a cDNA for rat prostacyclin receptor. Sasaki, Y., Usui, T., Tanaka, I., Nakagawa, O., Sando, T., Takahashi, T., Namba, T., Narumiya, S., Nakao, K. Biochim. Biophys. Acta (1994) [Pubmed]
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