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Chemical Compound Review

PGD2     (Z)-7-[(1R,2S,5S)-5-hydroxy- 2-[(E,3S)-3...

Synonyms: CHEMBL1235252, SureCN2508829, BSPBio_001486, CHEBI:15555, P5172_SIGMA, ...
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Disease relevance of prostaglandin D2


Psychiatry related information on prostaglandin D2


High impact information on prostaglandin D2


Chemical compound and disease context of prostaglandin D2


Biological context of prostaglandin D2


Anatomical context of prostaglandin D2

  • Taken together, we propose that the inhibition of LC migration could represent an additional stratagem for the schistosomes to escape the host immune system and that PGD2 may play a key role in the control of cutaneous immune responses [4].
  • 9 alpha,11 beta-PGF2 was a potent contractile agonist of isolated guinea pig trachea and 4-mm human airways in vitro; the potencies of the PGs relative to PGD2 (= 1.00) being 0.65 (NS) and 4.08 (P less than 0.001) for 9 alpha,11 beta-PGF2, and 0.52 (P less than 0.01) and 2.40 (P less than 0.001) for PGF2 alpha, respectively [23].
  • Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2 [21].
  • In contrast, PGD2 had no effect on the increase in short-circuit current caused by PGD2, substance P, or serotonin, the actions of which were not dependent on the presence of the submucosal plexus [21].
  • Moreover, in embryonic gonads, we detect a male-specific prostaglandin D synthase expression and an active PGD2 signal at the time and place of SOX9 expression [22].

Associations of prostaglandin D2 with other chemical compounds


Gene context of prostaglandin D2


Analytical, diagnostic and therapeutic context of prostaglandin D2


  1. Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. Poynard, T., Nataf, C., Messing, B., Modigliani, R., Lecompte, T., Nicolas, P., Dray, F., Ferme, C. N. Engl. J. Med. (1982) [Pubmed]
  2. Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells. Stringfellow, D.A., Fitzpatrick, F.A. Nature (1979) [Pubmed]
  3. Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. Honda, K., Arima, M., Cheng, G., Taki, S., Hirata, H., Eda, F., Fukushima, F., Yamaguchi, B., Hatano, M., Tokuhisa, T., Fukuda, T. J. Exp. Med. (2003) [Pubmed]
  4. Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. Angeli, V., Faveeuw, C., Roye, O., Fontaine, J., Teissier, E., Capron, A., Wolowczuk, I., Capron, M., Trottein, F. J. Exp. Med. (2001) [Pubmed]
  5. Characterization of the platelet prostaglandin D2 receptor. Loss of prostaglandin D2 receptors in platelets of patients with myeloproliferative disorders. Cooper, B., Ahern, D. J. Clin. Invest. (1979) [Pubmed]
  6. Prostaglandin D2, a cerebral sleep-inducing substance in rats. Ueno, R., Honda, K., Inoué, S., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  7. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Onoe, H., Ueno, R., Fujita, I., Nishino, H., Oomura, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. Nishino, S., Mignot, E., Fruhstorfer, B., Dement, W.C., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  9. Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. Kim, J., Yang, P., Suraokar, M., Sabichi, A.L., Llansa, N.D., Mendoza, G., Subbarayan, V., Logothetis, C.J., Newman, R.A., Lippman, S.M., Menter, D.G. Cancer Res. (2005) [Pubmed]
  10. Release of prostaglandin D2 into human airways during acute antigen challenge. Murray, J.J., Tonnel, A.B., Brash, A.R., Roberts, L.J., Gosset, P., Workman, R., Capron, A., Oates, J.A. N. Engl. J. Med. (1986) [Pubmed]
  11. Inflammatory mediators in late antigen-induced rhinitis. Naclerio, R.M., Proud, D., Togias, A.G., Adkinson, N.F., Meyers, D.A., Kagey-Sobotka, A., Plaut, M., Norman, P.S., Lichtenstein, L.M. N. Engl. J. Med. (1985) [Pubmed]
  12. The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. Hardy, C.C., Robinson, C., Tattersfield, A.E., Holgate, S.T. N. Engl. J. Med. (1984) [Pubmed]
  13. Inducible cyclooxygenase may have anti-inflammatory properties. Gilroy, D.W., Colville-Nash, P.R., Willis, D., Chivers, J., Paul-Clark, M.J., Willoughby, D.A. Nat. Med. (1999) [Pubmed]
  14. Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential. Fitzpatrick, F.A., Stringfellow, D.A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  15. Prostaglandin D2, a neuromodulator. Shimizu, T., Mizuno, N., Amano, T., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  16. Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. Ueno, R., Narumiya, S., Ogorochi, T., Nakayama, T., Ishikawa, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  17. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. Aritake, K., Kado, Y., Inoue, T., Miyano, M., Urade, Y. J. Biol. Chem. (2006) [Pubmed]
  18. Inactivation of human high molecular weight kininogen by human mast cell tryptase. Maier, M., Spragg, J., Schwartz, L.B. J. Immunol. (1983) [Pubmed]
  19. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y., Ichimasa, M., Sugamura, K., Nakamura, M., Takano, S., Nagata, K. J. Exp. Med. (2001) [Pubmed]
  20. The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. Murakami, M., Austen, K.F., Arm, J.P. J. Exp. Med. (1995) [Pubmed]
  21. Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2. Goerg, K.J., Wanitschke, R., Diener, M., Rummel, W. Gastroenterology (1992) [Pubmed]
  22. Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. Malki, S., Nef, S., Notarnicola, C., Thevenet, L., Gasca, S., Méjean, C., Berta, P., Poulat, F., Boizet-Bonhoure, B. EMBO J. (2005) [Pubmed]
  23. 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. Beasley, C.R., Robinson, C., Featherstone, R.L., Varley, J.G., Hardy, C.C., Church, M.K., Holgate, S.T. J. Clin. Invest. (1987) [Pubmed]
  24. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., Glass, C.K. Nature (1998) [Pubmed]
  25. Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. Dutta-Roy, A.K., Ray, T.K., Sinha, A.K. Science (1986) [Pubmed]
  26. Regulation of arachidonic acid, eicosanoid, and phospholipase A2 levels in murine mast cells by recombinant stem cell factor. Fonteh, A.N., Samet, J.M., Chilton, F.H. J. Clin. Invest. (1995) [Pubmed]
  27. Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. Schulman, E.S., Post, T.J., Henson, P.M., Giclas, P.C. J. Clin. Invest. (1988) [Pubmed]
  28. Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. Schleimer, R.P., Schulman, E.S., MacGlashan, D.W., Peters, S.P., Hayes, E.C., Adams, G.K., Lichtenstein, L.M., Adkinson, N.F. J. Clin. Invest. (1983) [Pubmed]
  29. Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. Feng, C., Beller, E.M., Bagga, S., Boyce, J.A. Blood (2006) [Pubmed]
  30. Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. Murakami, M., Matsumoto, R., Austen, K.F., Arm, J.P. J. Biol. Chem. (1994) [Pubmed]
  31. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Ward, C., Dransfield, I., Murray, J., Farrow, S.N., Haslett, C., Rossi, A.G. J. Immunol. (2002) [Pubmed]
  32. Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. Fonteh, A.N., Atsumi, G., LaPorte, T., Chilton, F.H. J. Immunol. (2000) [Pubmed]
  33. Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. Zayed, N., Afif, H., Chabane, N., Mfuna-Endam, L., Benderdour, M., Martel-Pelletier, J., Pelletier, J.P., Motiani, R.K., Trebak, M., Duval, N., Fahmi, H. Arthritis Rheum. (2008) [Pubmed]
  34. Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. Mandal, A.K., Zhang, Z., Ray, R., Choi, M.S., Chowdhury, B., Pattabiraman, N., Mukherjee, A.B. J. Exp. Med. (2004) [Pubmed]
  35. Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S.S., Kasahara, K., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  36. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Scammell, T., Gerashchenko, D., Urade, Y., Onoe, H., Saper, C., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  37. Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. Bertelé, V., Falanga, A., Tomasiak, M., Chiabrando, C., Cerletti, C., de Gaetano, G. Blood (1984) [Pubmed]
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