Chemical Compound Review:
Cicaprost 2-[(2E)-2-[(3aS,4R,5R,6aR)-5- hydroxy-4...
Synonyms:
Cicaprostum, AC1NSJVZ, SureCN61349, CHEMBL160629, ZK-96480, ...
- Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin a gene expression. Kothapalli, D., Stewart, S.A., Smyth, E.M., Azonobi, I., Pure, E., Assoian, R.K. Mol. Pharmacol. (2003)
- Rodent model of systemic mammary tumor disease by surgical removal of the spontaneously metastasizing SMT2A mammary carcinoma: inhibitory effect of the stable prostacyclin analogue cicaprost on occult metastasis. Schirner, M., Schneider, M.R. Int. J. Cancer (1995)
- Antiatherosclerotic effects of oral cicaprost in experimental hypercholesterolemia in rabbits. Braun, M., Hohlfeld, T., Kienbaum, P., Weber, A.A., Sarbia, M., Schrör, K. Atherosclerosis (1993)
- Activation of IP prostanoid receptors prevents cardiomyocyte hypertrophy via cAMP-dependent signaling. Ritchie, R.H., Rosenkranz, A.C., Huynh, L.P., Stephenson, T., Kaye, D.M., Dusting, G.J. Am. J. Physiol. Heart Circ. Physiol. (2004)
- The prostacyclin analogue cicaprost inhibits metastasis of tumours of R 3327 MAT Lu prostate carcinoma and SMT 2A mammary carcinoma. Schirner, M., Schneider, M.R. J. Cancer Res. Clin. Oncol. (1992)
- Internalization and Recycling of the Human Prostacyclin Receptor Is Modulated through Its Isoprenylation-dependent Interaction with the {delta} Subunit of cGMP Phosphodiesterase 6. Wilson, S.J., Smyth, E.M. J. Biol. Chem. (2006)
- Antimitogenesis linked to regulation of Skp2 gene expression. Stewart, S.A., Kothapalli, D., Yung, Y., Assoian, R.K. J. Biol. Chem. (2004)
- The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin. Reid, H.M., Kinsella, B.T. J. Biol. Chem. (2003)
- Localization of IP in rabbit kidney and functional role of the PGI(2)/IP system in cortical collecting duct. Nasrallah, R., Nusing, R.M., Hébert, R.L. Am. J. Physiol. Renal Physiol. (2002)
- Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism. Orie, N.N., Fry, C.H., Clapp, L.H. Cardiovasc. Res. (2006)
- Effects of cicaprost and fosinopril on the progression of rat diabetic nephropathy. Villa, E., Rábano, A., Ruilope, L.M., García-Robles, R. Am. J. Hypertens. (1997)
- The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization. Walsh, M.T., Foley, J.F., Kinsella, B.T. J. Biol. Chem. (2000)
- Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling. Lawler, O.A., Miggin, S.M., Kinsella, B.T. J. Biol. Chem. (2001)
- Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Clapp, L.H., Finney, P., Turcato, S., Tran, S., Rubin, L.J., Tinker, A. Am. J. Respir. Cell Mol. Biol. (2002)
- Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission. Qian, Y.M., Jones, R.L. Br. J. Pharmacol. (1995)
- Distinction between relaxations induced via prostanoid EP(4) and IP(1) receptors in pig and rabbit blood vessels. Jones, R.L., Chan, K. Br. J. Pharmacol. (2001)
- Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Jones, R.L., Wise, H., Clark, R., Whiting, R.L., Bley, K.R. Br. J. Pharmacol. (2006)
- Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors. Armstrong, R.A., Lawrence, R.A., Jones, R.L., Wilson, N.H., Collier, A. Br. J. Pharmacol. (1989)
- Cyclooxygenase-2 regulates granulocyte-macrophage colony-stimulating factor, but not interleukin-8, production by human vascular cells: role of cAMP. Stanford, S.J., Pepper, J.R., Mitchell, J.A. Arterioscler. Thromb. Vasc. Biol. (2000)
- Expression of prostacyclin receptors in luteinizing hormone-releasing hormone immortalized neurons: role in the control of hormone secretion. Pimpinelli, F., Rovati, G.E., Capra, V., Piva, F., Martini, L., Maggi, R. Endocrinology (1999)
- Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. Eigler, A., Siegmund, B., Emmerich, U., Baumann, K.H., Hartmann, G., Endres, S. J. Leukoc. Biol. (1998)
- Regulation of tumor necrosis factor alpha- and interleukin-1-beta-induced induced adhesion molecule expression in human vascular smooth muscle cells by cAMP. Braun, M., Pietsch, P., Zepp, A., Schrör, K., Baumann, G., Felix, S.B. Arterioscler. Thromb. Vasc. Biol. (1997)
- Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK. Lo, R.K., Wise, H., Wong, Y.H. Cell. Signal. (2006)
- Cicaprost, an orally active prostacyclin analogue: its effects on platelet aggregation and skin blood flow in normal volunteers. Belch, J.J., McLaren, M., Lau, C.S., Mackay, I.R., Bancroft, A., McEwen, J., Thompson, J.M. British journal of clinical pharmacology. (1993)
- Cicaprost, a prostacyclin analog, protects renal function in uninephrectomized dogs in the absence of changes in blood pressure. Villa, E., Martinez, J., Ruilope, L.M., Mampaso, F., Sancho, J.M., Robles, R.G. Am. J. Hypertens. (1993)
- Tumor metastasis inhibition with the prostacyclin analogue cicaprost depends on discontinuous plasma peak levels. Schirner, M., Kraus, C., Lichtner, R.B., Schneider, M.R., Hildebrand, M. Prostaglandins Leukot. Essent. Fatty Acids (1998)
- A randomised, double-blind study of cicaprost, an oral prostacyclin analogue, in the treatment of Raynaud's phenomenon secondary to systemic sclerosis. Lau, C.S., Belch, J.J., Madhok, R., Cappell, H., Herrick, A., Jayson, M., Thompson, J.M. Clinical and experimental rheumatology. (1993)
- Pharmacokinetics and pharmacodynamics of cicaprost in healthy volunteers after oral administration of 5 to 20 micrograms. Hildebrand, M., Staks, T., Nieuweboer, B. Eur. J. Clin. Pharmacol. (1990)