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Ptgir  -  prostaglandin I2 (prostacyclin) receptor (IP)

Rattus norvegicus

Synonyms: PGI receptor, PGI2 receptor, Prostacyclin receptor, Prostaglandin I2 receptor, Prostanoid IP receptor
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Disease relevance of Ptgir_predicted


High impact information on Ptgir_predicted


Biological context of Ptgir_predicted


Anatomical context of Ptgir_predicted


Associations of Ptgir_predicted with chemical compounds

  • 2. NG108-15 cells incubated acutely with ethanol (1-200 mM) displayed concentration-dependent increases in basal and iloprost-stimulated (300 nM; a prostanoid IP receptor agonist) cyclic AMP accumulation but a concentration-dependent decrease in forskolin-stimulated (10 microM) accumulation [10].
  • A prostacyclin receptor antagonist inhibits the sensitized release of substance P from rat sensory neurons [11].

Analytical, diagnostic and therapeutic context of Ptgir_predicted


  1. Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia. Takamatsu, H., Tsukada, H., Watanabe, Y., Cui, Y., Kataoka, Y., Hosoya, T., Suzuki, M., Watanabe, Y. Brain Res. (2002) [Pubmed]
  2. Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. Nakae, K., Hayashi, F., Hayashi, M., Yamamoto, N., Iino, T., Yoshikawa, S., Gupta, J. Neurosci. Lett. (2005) [Pubmed]
  3. A novel subtype of the prostacyclin receptor expressed in the central nervous system. Takechi, H., Matsumura, K., Watanabe, Y., Kato, K., Noyori, R., Suzuki, M., Watanabe, Y. J. Biol. Chem. (1996) [Pubmed]
  4. Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. Liu, Y., Rusch, N.J., Lombard, J.H. Hypertension (1999) [Pubmed]
  5. Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Numaguchi, Y., Harada, M., Osanai, H., Hayashi, K., Toki, Y., Okumura, K., Ito, T., Hayakawa, T. Cardiovasc. Res. (1999) [Pubmed]
  6. Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor. Merritt, J.E., Hallam, T.J., Brown, A.M., Boyfield, I., Cooper, D.G., Hickey, D.M., Jaxa-Chamiec, A.A., Kaumann, A.J., Keen, M., Kelly, E. Br. J. Pharmacol. (1991) [Pubmed]
  7. Cloning and expression of a cDNA for rat prostacyclin receptor. Sasaki, Y., Usui, T., Tanaka, I., Nakagawa, O., Sando, T., Takahashi, T., Namba, T., Narumiya, S., Nakao, K. Biochim. Biophys. Acta (1994) [Pubmed]
  8. Differential expression of prostanoid receptors in hepatocytes, Kupffer cells, sinusoidal endothelial cells and stellate cells of rat liver. Fennekohl, A., Schieferdecker, H.L., Jungermann, K., Püschel, G.P. J. Hepatol. (1999) [Pubmed]
  9. Prostacyclin receptor in the brain and central terminals of the primary sensory neurons: an autoradiographic study using a stable prostacyclin analogue [3H]iloprost. Matsumura, K., Watanabe, Y., Onoe, H., Watanabe, Y. Neuroscience (1995) [Pubmed]
  10. Effects of acute and chronic ethanol on cyclic AMP accumulation in NG108-15 cells: differential dependence of changes on extracellular adenosine. Kelly, E., Harrison, P.K., Williams, R.J. Br. J. Pharmacol. (1995) [Pubmed]
  11. A prostacyclin receptor antagonist inhibits the sensitized release of substance P from rat sensory neurons. Nakae, K., Saito, K., Iino, T., Yamamoto, N., Wakabayashi, M., Yoshikawa, S., Matsushima, S., Miyashita, H., Sugimoto, H., Kiba, A., Gupta, J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  12. Characterization of the PGI2/IP system in cultured rat mesangial cells. Nasrallah, R., Landry, A., Scholey, J.W., Hébert, R.L. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
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