The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Ptgir  -  prostaglandin I2 (prostacyclin) receptor (IP)

Rattus norvegicus

Synonyms: PGI receptor, PGI2 receptor, Prostacyclin receptor, Prostaglandin I2 receptor, Prostanoid IP receptor
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Ptgir_predicted

 

High impact information on Ptgir_predicted

 

Biological context of Ptgir_predicted

 

Anatomical context of Ptgir_predicted

 

Associations of Ptgir_predicted with chemical compounds

  • 2. NG108-15 cells incubated acutely with ethanol (1-200 mM) displayed concentration-dependent increases in basal and iloprost-stimulated (300 nM; a prostanoid IP receptor agonist) cyclic AMP accumulation but a concentration-dependent decrease in forskolin-stimulated (10 microM) accumulation [10].
  • A prostacyclin receptor antagonist inhibits the sensitized release of substance P from rat sensory neurons [11].
 

Analytical, diagnostic and therapeutic context of Ptgir_predicted

References

  1. Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia. Takamatsu, H., Tsukada, H., Watanabe, Y., Cui, Y., Kataoka, Y., Hosoya, T., Suzuki, M., Watanabe, Y. Brain Res. (2002) [Pubmed]
  2. Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. Nakae, K., Hayashi, F., Hayashi, M., Yamamoto, N., Iino, T., Yoshikawa, S., Gupta, J. Neurosci. Lett. (2005) [Pubmed]
  3. A novel subtype of the prostacyclin receptor expressed in the central nervous system. Takechi, H., Matsumura, K., Watanabe, Y., Kato, K., Noyori, R., Suzuki, M., Watanabe, Y. J. Biol. Chem. (1996) [Pubmed]
  4. Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. Liu, Y., Rusch, N.J., Lombard, J.H. Hypertension (1999) [Pubmed]
  5. Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Numaguchi, Y., Harada, M., Osanai, H., Hayashi, K., Toki, Y., Okumura, K., Ito, T., Hayakawa, T. Cardiovasc. Res. (1999) [Pubmed]
  6. Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor. Merritt, J.E., Hallam, T.J., Brown, A.M., Boyfield, I., Cooper, D.G., Hickey, D.M., Jaxa-Chamiec, A.A., Kaumann, A.J., Keen, M., Kelly, E. Br. J. Pharmacol. (1991) [Pubmed]
  7. Cloning and expression of a cDNA for rat prostacyclin receptor. Sasaki, Y., Usui, T., Tanaka, I., Nakagawa, O., Sando, T., Takahashi, T., Namba, T., Narumiya, S., Nakao, K. Biochim. Biophys. Acta (1994) [Pubmed]
  8. Differential expression of prostanoid receptors in hepatocytes, Kupffer cells, sinusoidal endothelial cells and stellate cells of rat liver. Fennekohl, A., Schieferdecker, H.L., Jungermann, K., Püschel, G.P. J. Hepatol. (1999) [Pubmed]
  9. Prostacyclin receptor in the brain and central terminals of the primary sensory neurons: an autoradiographic study using a stable prostacyclin analogue [3H]iloprost. Matsumura, K., Watanabe, Y., Onoe, H., Watanabe, Y. Neuroscience (1995) [Pubmed]
  10. Effects of acute and chronic ethanol on cyclic AMP accumulation in NG108-15 cells: differential dependence of changes on extracellular adenosine. Kelly, E., Harrison, P.K., Williams, R.J. Br. J. Pharmacol. (1995) [Pubmed]
  11. A prostacyclin receptor antagonist inhibits the sensitized release of substance P from rat sensory neurons. Nakae, K., Saito, K., Iino, T., Yamamoto, N., Wakabayashi, M., Yoshikawa, S., Matsushima, S., Miyashita, H., Sugimoto, H., Kiba, A., Gupta, J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  12. Characterization of the PGI2/IP system in cultured rat mesangial cells. Nasrallah, R., Landry, A., Scholey, J.W., Hébert, R.L. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
 
WikiGenes - Universities