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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Alpha-particle-induced chromosomal instability in human bone marrow cells.

alpha-particles, which are ionising radiation of high linear-energy-transfer emitted, for example, from radon or plutonium, pass through tissue as highly structured tracks. Single target cells in the path of the tracks might be damaged by even low-dose alpha-irradiation. We found non-clonal cytogenetic aberrations, characterised by a high frequency of chromatid aberrations with chromosome aberrations, in clonal descendants of haemopoietic stem cells after exposure to alpha-particles of bone marrow cells from two of four haematologically normal individuals (up to 25% abnormal metaphases). The data are consistent with a transmissible genetic instability induced in a stem cell resulting in a diversity of aberrations in its clonal progeny many cell divisions later.[1]

References

  1. Alpha-particle-induced chromosomal instability in human bone marrow cells. Kadhim, M.A., Lorimore, S.A., Hepburn, M.D., Goodhead, D.T., Buckle, V.J., Wright, E.G. Lancet (1994) [Pubmed]
 
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