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MeSH Review

Chromosomal Instability

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Disease relevance of Chromosomal Instability


Psychiatry related information on Chromosomal Instability


High impact information on Chromosomal Instability


Chemical compound and disease context of Chromosomal Instability


Biological context of Chromosomal Instability


Anatomical context of Chromosomal Instability


Associations of Chromosomal Instability with chemical compounds


Gene context of Chromosomal Instability


Analytical, diagnostic and therapeutic context of Chromosomal Instability


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  2. Cytoplasmic localization of FAC is essential for the correction of a prerepair defect in Fanconi anemia group C cells. Youssoufian, H. J. Clin. Invest. (1996) [Pubmed]
  3. A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. van der Burg, M., van Veelen, L.R., Verkaik, N.S., Wiegant, W.W., Hartwig, N.G., Barendregt, B.H., Brugmans, L., Raams, A., Jaspers, N.G., Zdzienicka, M.Z., van Dongen, J.J., van Gent, D.C. J. Clin. Invest. (2006) [Pubmed]
  4. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. de Winter, J.P., Léveillé, F., van Berkel, C.G., Rooimans, M.A., van Der Weel, L., Steltenpool, J., Demuth, I., Morgan, N.V., Alon, N., Bosnoyan-Collins, L., Lightfoot, J., Leegwater, P.A., Waisfisz, Q., Komatsu, K., Arwert, F., Pronk, J.C., Mathew, C.G., Digweed, M., Buchwald, M., Joenje, H. Am. J. Hum. Genet. (2000) [Pubmed]
  5. Patients with an inherited syndrome characterized by immunodeficiency, microcephaly, and chromosomal instability: genetic relationship to ataxia telangiectasia. Jaspers, N.G., Taalman, R.D., Baan, C. Am. J. Hum. Genet. (1988) [Pubmed]
  6. Chromosomal instability at common fragile sites in Seckel syndrome. Casper, A.M., Durkin, S.G., Arlt, M.F., Glover, T.W. Am. J. Hum. Genet. (2004) [Pubmed]
  7. Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Wang, Y., Putnam, C.D., Kane, M.F., Zhang, W., Edelmann, L., Russell, R., Carrión, D.V., Chin, L., Kucherlapati, R., Kolodner, R.D., Edelmann, W. Nat. Genet. (2005) [Pubmed]
  8. Chfr is required for tumor suppression and Aurora A regulation. Yu, X., Minter-Dykhouse, K., Malureanu, L., Zhao, W.M., Zhang, D., Merkle, C.J., Ward, I.M., Saya, H., Fang, G., van Deursen, J., Chen, J. Nat. Genet. (2005) [Pubmed]
  9. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003) [Pubmed]
  10. Securin is required for chromosomal stability in human cells. Jallepalli, P.V., Waizenegger, I.C., Bunz, F., Langer, S., Speicher, M.R., Peters, J.M., Kinzler, K.W., Vogelstein, B., Lengauer, C. Cell (2001) [Pubmed]
  11. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Rabenau, K.E., O'Toole, J.M., Bassi, R., Kotanides, H., Witte, L., Ludwig, D.L., Pereira, D.S. Oncogene (2004) [Pubmed]
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  13. The effects of severe mixed environmental pollution on human chromosomes. Katsantoni, A., Nakou, S., Antoniadou-Koumatou, I., Côté, G.B. J. Med. Genet. (1986) [Pubmed]
  14. The need for more accurate and timely diagnosis in Fanconi anemia: a report from the International Fanconi Anemia Registry. Giampietro, P.F., Adler-Brecher, B., Verlander, P.C., Pavlakis, S.G., Davis, J.G., Auerbach, A.D. Pediatrics (1993) [Pubmed]
  15. Increased bleomycin-induced chromosome damage in lymphocytes of patients with common variable immunodeficiency indicates an involvement of chromosomal instability in their cancer predisposition. Vorechovsky, I., Munzarova, M., Lokaj, J. Cancer Immunol. Immunother. (1989) [Pubmed]
  16. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Peters, A.H., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., Opravil, S., Doyle, M., Sibilia, M., Jenuwein, T. Cell (2001) [Pubmed]
  17. Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. Walsh, C.E., Nienhuis, A.W., Samulski, R.J., Brown, M.G., Miller, J.L., Young, N.S., Liu, J.M. J. Clin. Invest. (1994) [Pubmed]
  18. Mutations in the APC tumour suppressor gene cause chromosomal instability. Fodde, R., Kuipers, J., Rosenberg, C., Smits, R., Kielman, M., Gaspar, C., van Es, J.H., Breukel, C., Wiegant, J., Giles, R.H., Clevers, H. Nat. Cell Biol. (2001) [Pubmed]
  19. Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Reeves, H.L., Narla, G., Ogunbiyi, O., Haq, A.I., Katz, A., Benzeno, S., Hod, E., Harpaz, N., Goldberg, S., Tal-Kremer, S., Eng, F.J., Arthur, M.J., Martignetti, J.A., Friedman, S.L. Gastroenterology (2004) [Pubmed]
  20. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. Hande, M.P., Samper, E., Lansdorp, P., Blasco, M.A. J. Cell Biol. (1999) [Pubmed]
  21. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Hicks, G.G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L., Arapovic, D., White, E.K., Koury, M.J., Oltz, E.M., Van Kaer, L., Ruley, H.E. Nat. Genet. (2000) [Pubmed]
  22. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Kaplan, K.B., Burds, A.A., Swedlow, J.R., Bekir, S.S., Sorger, P.K., Näthke, I.S. Nat. Cell Biol. (2001) [Pubmed]
  23. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Ferguson, D.O., Sekiguchi, J.M., Chang, S., Frank, K.M., Gao, Y., DePinho, R.A., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  24. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Starita, L.M., Machida, Y., Sankaran, S., Elias, J.E., Griffin, K., Schlegel, B.P., Gygi, S.P., Parvin, J.D. Mol. Cell. Biol. (2004) [Pubmed]
  25. An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Demuth, I., Frappart, P.O., Hildebrand, G., Melchers, A., Lobitz, S., Stöckl, L., Varon, R., Herceg, Z., Sperling, K., Wang, Z.Q., Digweed, M. Hum. Mol. Genet. (2004) [Pubmed]
  26. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA. Lo Ten Foe, J.R., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., van Berkel, C.G., Strunk, M.H., Gille, J.J., Pals, G., Kruyt, F.A., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H. Nat. Genet. (1996) [Pubmed]
  27. A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Schreiber, V., Hunting, D., Trucco, C., Gowans, B., Grunwald, D., De Murcia, G., De Murcia, J.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. Production of functional human T-T hybridomas in selection medium lacking aminopterin and thymidine. Foung, S.K., Sasaki, D.T., Grumet, F.C., Engleman, E.G. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  29. Carcinogen-specific induction of genetic instability. Bardelli, A., Cahill, D.P., Lederer, G., Speicher, M.R., Kinzler, K.W., Vogelstein, B., Lengauer, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  30. Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. Jorquera, R., Tanguay, R.M. Hum. Mol. Genet. (2001) [Pubmed]
  31. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Gatei, M., Young, D., Cerosaletti, K.M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M.F., Gatti, R.A., Concannon, P., Khanna, K. Nat. Genet. (2000) [Pubmed]
  32. Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis. Puizina, J., Siroky, J., Mokros, P., Schweizer, D., Riha, K. Plant Cell (2004) [Pubmed]
  33. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Landry, J., Sutton, A., Tafrov, S.T., Heller, R.C., Stebbins, J., Pillus, L., Sternglanz, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  34. Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Middleman, E.J., Choi, J., Venteicher, A.S., Cheung, P., Artandi, S.E. Mol. Cell. Biol. (2006) [Pubmed]
  35. BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Westermark, U.K., Reyngold, M., Olshen, A.B., Baer, R., Jasin, M., Moynahan, M.E. Mol. Cell. Biol. (2003) [Pubmed]
  36. Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer. Yoon, D.S., Wersto, R.P., Zhou, W., Chrest, F.J., Garrett, E.S., Kwon, T.K., Gabrielson, E. Am. J. Pathol. (2002) [Pubmed]
  37. Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer. Gervaz, P., Cerottini, J.P., Bouzourene, H., Hahnloser, D., Doan, C.L., Benhattar, J., Chaubert, P., Secic, M., Gillet, M., Carethers, J.M. Surgery (2002) [Pubmed]
  38. Spectral karyotyping of sarcomas and fibroblasts derived from Ink4a/Arf-deficient mice reveals chromosomal instability in vitro. Robertson, S.A., Schoumans, J., Looyenga, B.D., Yuhas, J.A., Zylstra, C.R., Koeman, J.M., Swiatek, P.J., Teh, B.T., Williams, B.O. Int. J. Oncol. (2005) [Pubmed]
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