Disease relevance of Linear Energy Transfer

• Effect of exogenous wild-type p53 on melanoma cell death pathways induced by irradiation at different linear energy transfer [1].

High impact information on Linear Energy Transfer

• alpha-particles, which are ionising radiation of high linear-energy-transfer emitted, for example, from radon or plutonium, pass through tissue as highly structured tracks [2].
• PURPOSE: The somatostatin analogue [DOTA0, Tyr3]octreotide (DOTATOC) has previously been labeled with low linear energy transfer (LET) beta-emitters, such as 177Lu or 90Y, for tumor therapy [3].
• The mutagenic potential of charged particles of defined linear energy transfer (LET) was assessed using the hypoxanthine-guanine phosphoribosyl transferase locus (HGPRT) in primary human fibroblasts [4].
• M059J cells accumulated mainly in S phase after high linear energy transfer irradiation [5].
• PURPOSE: The aim of this study is to investigate the dependence of p53-gene status on the radiation enhancement of thermosensitivity at different levels of linear energy transfer (LET) [6].

Biological context of Linear Energy Transfer

• The increase in relative biological effectiveness with higher linear energy transfer for tritium beta radiation strongly suggests that single-strand breaks are repaired by a nearly error-free repair mechanism [7].
• Amplification of the c-myc oncogene in radiation-induced rat skin tumors as a function of linear energy transfer and dose [8].
• We investigated the effect of exogenous wild-type p53 on the radiation-induced cells apoptosis and necrosis at different levels of linear energy transfer (LET) to evaluate its mechanisms [1].

Anatomical context of Linear Energy Transfer

• We have characterized a series of 69 independent mutants at the endogenous hprt locus of human TK6 lymphoblasts and over 200 independent S1-deficient mutants of the human x hamster hybrid cell line AL arising spontaneously or following low-fluence exposures to densely ionizing Fe ions (600 MeV/amu, linear energy transfer = 190 keV/microns) [9].

Associations of Linear Energy Transfer with chemical compounds

• Little is known about radiosensitization produced by iododeoxyuridine (IUDR) with high linear energy transfer radiation [10].
• The high linear energy transfer, alpha-particle-emitting radionuclide astatine-211 (211At) is of interest for certain therapeutic applications; however, because of the 55- to 70-microm path length of its alpha-particles, achieving homogeneous tracer distribution is critical [11].
• We examined the correlation between the production of sucrose radicals and the ion species, as well as LET (linear energy transfer) [12].
• A technique, Photon Activation Therapy (PAT), is described in which high Linear Energy Transfer (LET) radiations in the form of Auger electron distributions are generated by a photon beam through photoactivation of stable iodine incorporated as an analog of thymidine (Tyd) in DNA [13].
• Boron-10 (10B) is a stable isotope which, when irradiated with thermal neutrons, produces a capture reaction yielding high linear energy transfer particles (10B + 1nth----[11B]----4He(alpha) + 7Li + 2.79 MeV) [14].

Gene context of Linear Energy Transfer

• A survival curve showed an initial shoulder and became steeper beyond 200-250 pCi cell-1 (low linear energy transfer type) [15].
• RESULTS: For protons, SSB yield decreased with increasing LET (linear energy transfer) [16].
• These findings are consistent with a model for ssb and dsb induction by high linear energy transfer radiation that involves OH radical medication [17].
• In deaerated water, for a linear energy transfer (LET) of 250 eV/nm, the yield of HO2/O2- is (6 +/- 2) x 10(-9) mol J-1 [18].
• The effects of low linear energy transfer (LET) radiation on mammalian cells have been studied at dose-rates as high as 10(9) Gy/sec delivered as a single 3-nanosecond pulse, and no increase in cytotoxicity was shown compared with delivery at a conventional dose-rate [19].

References