The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

delta 5-Androstene-3 beta,17 beta-diol in healthy eumenorrheic women: relationship to body mass and hormonal profile.

OBJECTIVE: To determine whether delta 5-Androstene-3 beta,17 beta-diol or androstenediol secretion increases with body mass. DESIGN: A prospective study. SETTING: University-based clinical research center. PATIENTS: Twenty healthy, nonhirsute, eumenorrheic women, 10 with a body mass index (BMI) < 31 kg/m2 and 10 with a BMI > 31 kg/m2 were studied. INTERVENTIONS: All patients had blood sampled before (0 minute) and 60 minute after acute administration of 1 mg ACTH-(1-24) i.v. Body circumferences were obtained, and the BMI and waist-hip ratio was calculated. MAIN OUTCOME MEASURES: Total T, androstenedione (A), E2, sex hormone binding globulin, DHEA, DHEAS, and androstenediol were measured at 0 minutes (steroid 0): and DHEA, A and androstenediol were also measured after stimulation (steroid 60). The net steroid increment (delta) from 0 to 60 minute was calculated. RESULTS: Compared with thin women, obese subjects had higher levels of androstenediol 60 (95.8 +/- 20.3 versus 130.7 +/- 40.7 ng/dL, respectively [conversion factor to SI units, 0.03443]) and delta androstenediol (17.4 +/- 8.7 versus 37.8 +/- 29.0 ng/dL, respectively [conversion factor to SI units, 0.03443]). Neither the BMI, height, nor the body circumference measures correlated with any of the steroid levels or responses to adrenal stimulation, except for a weak positive correlation between BMI and estrone (E1) (r = 0.38) and a negative correlation between waist-hip ratio and delta androstenediol (r = -0.51). The basal level of T, E1, and DHEA0, but not A or DHEAS, correlated with androstenediol 0 (r = 0.65, 0.62, and 0.67, respectively) and delta androstenediol (r = 0.66, 0.63, and 0.63 to 0.005, respectively). CONCLUSIONS: Although the unstimulated morning androstenediol level did not differ between obese and thin euandrogenic healthy women, the response of androstenediol to ACTH-(1-24) stimulation was greater in obese individuals. The present findings, together with our previous data demonstrating an increased adrenal secretion of the E1 precursor A in response to ACTH in obese women, suggests that the adrenal cortex in overweight women may further enhance the estrogenic milieu of these women.[1]


WikiGenes - Universities