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MeSH Review: 

International System of Units

 
 
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Disease relevance of International System of Units

  • (The conversion factor for standard units to SI units is 1 gL = 3.2 mM.) CONCLUSIONS--Total serum sialic acid levels were significantly elevated in a relatively small group of NIDDM patients and were correlated with hypertension and retinopathy [1].
  • Using Cox regression, four significant variables were found to be associated with lower late survival rates: male gender, diabetes, chronic renal insufficiency (patients with creatinine levels greater than or equal to 1.7 mg/dl or 150 SI units), and a history of cerebrovascular disease (p < 0.001 for model) [2].
  • The concentration of MCP-1 (median, range of values) was increased in the PF of endometriosis patients (283, 0 to 1,930 pg/mL; conversion factor to SI unit, 0.155) compared with the control group (140, 0 to 435 pg/mL) [3].
 

High impact information on International System of Units

  • The estrogenic activity measured by RCUB [mean +/- sd, 11.9 +/- 10.9 pmol/liter (SI units, 3.23 +/- 2.96 pg/ml] was significantly lower than estradiol levels measured by RIA [43.7 +/- 44.0 pmol/liter (11.9 +/- 12.0 pg/ml)] in our volunteer subjects (P < 0.00001) [4].
  • RESULTS: The concentration of human cTnI in SRM 2921 is 31.2 (1.4) mg/L (where 1.4 mg/L is the uncertainty at a 95% level of confidence), as certified through a method that provides traceability to the International System of Units (SI) [5].
  • When each test is measured precisely and without bias, the ratio of TIBC (mumol/L) to TRF (g/L) in SI units is close to the theoretically expected value of 25.0 [6].
  • Comparison of midcycle PRL between groups showed differences only between bioactive PRL (34.2 +/- 8.3 versus 19.2 +/- 3.4 ng/mL [conversion factor to SI unit, 1.00]) [7].
  • INTERVENTION(S): Oral dexamethasone (DEX) administration if P level exceeded 0.8 ng/mL (conversion factor to SI unit, 3.180) after pituitary suppression [8].
 

Biological context of International System of Units

 

Anatomical context of International System of Units

  • Previous IVF-ET attempts had been uneventful and during the complicated trial, estradiol peak levels and numbers of oocytes retrieved remained below 2,500 pg/mL (conversion factor to SI unit, 3.671) and 10, respectively [10].
 

Associations of International System of Units with chemical compounds

  • In diabetics, basal LH levels and pulse amplitude decreased significantly during DA infusion (3.1 +/- 1.2 mIU/mL (conversion factor to SI unit, 1.00; mean +/- SD) and 0.9 +/- 0.3 mIU/mL, respectively) compared with placebo (4.5 +/- 1.1 and 1.2 +/- 0.4 mIU/mL, respectively) [11].
  • Peak P in the captopril group was significantly lower than controls (81.8 +/- 27.8 versus 208.5 +/- 23.9 ng/mL [conversion factor to SI unit, 3.180]) [12].
  • RESULTS: Basal T levels decreased to 5.37 +/- 67 ng/mL from 8.68 +/- 93 ng/mL (conversion factor to SI unit, 3.47) immediately after overtraining and basal cortisol levels increased to 215.3 +/- 31 ng/mL from 145.7 +/- 27 ng/mL (conversion factor to SI unit, 2.76) [13].
  • RESULTS: Fasting glucose (115 +/- 5 versus 109 +/- 4 mg/dL; conversion factor to SI units 0.05551) and insulin (1.67 +/- 0.24 versus 1.51 +/- 0.22 ng/mL; conversion factor to SI units 174.5) levels were not significantly different in the control and P treated groups, respectively [14].
  • RESULTS: Compared with thin women, obese subjects had higher levels of androstenediol 60 (95.8 +/- 20.3 versus 130.7 +/- 40.7 ng/dL, respectively [conversion factor to SI units, 0.03443]) and delta androstenediol (17.4 +/- 8.7 versus 37.8 +/- 29.0 ng/dL, respectively [conversion factor to SI units, 0.03443]) [15].
 

Gene context of International System of Units

  • A proposed reference method for plasminogen activators that enables calculation of enzyme activities in SI units [16].
  • RESULT: Approximately 50% of the PF samples had EGF concentrations of > 0.4 pg/mL (conversion factor to SI unit, 0.17) and 90% had basic FGF concentrations of > 1 pg/mL (conversion factor to SI unit, 0.058) [17].
  • RESULTS: Baseline PRL levels ranged from 3.64 to 19.23 ng/mL (mean 7.17 ng/mL; conversion factor to SI unit, 1.00) [18].
  • RESULT(S): The clinical PR in fresh cycles was 24% for the P < or = 0.9 ng/mL group (group A; conversion factor to SI unit, 3.18) and 34% for the P > 0.9 ng/mL group (group B) [19].
  • SI units of TDF [20].
 

Analytical, diagnostic and therapeutic context of International System of Units

References

  1. Elevated serum sialic acid concentration in NIDDM and its relationship to blood pressure and retinopathy. Crook, M.A., Tutt, P., Pickup, J.C. Diabetes Care (1993) [Pubmed]
  2. Predictors of long-term patient survival after in situ vein leg bypass. Kalman, P.G., Johnston, K.W. J. Vasc. Surg. (1997) [Pubmed]
  3. Elevated concentration and biologic activity of monocyte chemotactic protein-1 in the peritoneal fluid of patients with endometriosis. Akoum, A., Lemay, A., McColl, S., Turcot-Lemay, L., Maheux, R. Fertil. Steril. (1996) [Pubmed]
  4. Recombinant cell ultrasensitive bioassay for measurement of estrogens in postmenopausal women. Wang, S., Paris, F., Sultan, C.S., Song, R.X., Demers, L.M., Sundaram, B., Settlage, J., Ohorodnik, S., Santen, R.J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  5. Characterization of a new certified reference material for human cardiac troponin I. Bunk, D.M., Welch, M.J. Clin. Chem. (2006) [Pubmed]
  6. The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum. Gambino, R., Desvarieux, E., Orth, M., Matan, H., Ackattupathil, T., Lijoi, E., Wimmer, C., Bower, J., Gunter, E. Clin. Chem. (1997) [Pubmed]
  7. Midcycle increase of prolactin seen in normal women is absent in subjects with unexplained infertility. Subramanian, M.G., Kowalczyk, C.L., Leach, R.E., Lawson, D.M., Blacker, C.M., Ginsburg, K.A., Randolph, J.F., Diamond, M.P., Moghissi, K.S. Fertil. Steril. (1997) [Pubmed]
  8. Elevated serum progesterone levels during pituitary suppression may signify adrenal hyperandrogenism. Eldar-Geva, T., Margalioth, E.J., Brooks, B., Algur, N., Gal, M., Zylber-Haran, E., Bar, I., Diamant, Y.Z. Fertil. Steril. (1997) [Pubmed]
  9. Methyltetrahydrophthalic acid in urine as an indicator of occupational exposure to methyltetrahydrophthalic anhydride. Yokota, K., Johyama, Y., Kunitani, Y., Michitsuji, H., Yamada, S. International archives of occupational and environmental health. (2005) [Pubmed]
  10. Unpredictable cases of complicated ovarian hyperstimulation in IVF. Delvigne, A., Vandromme, J., Demeestere, I., Leroy, F. International journal of fertility and women's medicine. (1997) [Pubmed]
  11. Dopaminergic inhibition of pulsatile luteinizing hormone secretion is abnormal in regularly menstruating women with insulin-dependent diabetes mellitus. Grodum, E., Hangaard, J., Christensen, L., Haug, E., Hagen, C. Fertil. Steril. (1995) [Pubmed]
  12. Angiotensin-converting enzyme inhibition reverses luteal phase steroid production in oocyte donors. Morris, R.S., Paulson, R.J., Lindheim, S.R., Legro, R.S., Lobo, R.A., Sauer, M.V. Fertil. Steril. (1995) [Pubmed]
  13. Overtraining affects male reproductive status. Roberts, A.C., McClure, R.D., Weiner, R.I., Brooks, G.A. Fertil. Steril. (1993) [Pubmed]
  14. Progesterone administration induced impairment of insulin suppression of hepatic glucose production. Nelson, T., Shulman, G., Grainger, D., Diamond, M.P. Fertil. Steril. (1994) [Pubmed]
  15. delta 5-Androstene-3 beta,17 beta-diol in healthy eumenorrheic women: relationship to body mass and hormonal profile. Azziz, R., Potter, H.D., Bradley, E.L., Boots, L.R. Fertil. Steril. (1994) [Pubmed]
  16. A proposed reference method for plasminogen activators that enables calculation of enzyme activities in SI units. Longstaff, C., Whitton, C.M. J. Thromb. Haemost. (2004) [Pubmed]
  17. Epidermal growth factor and basic fibroblast growth factor in peritoneal fluid of women with endometriosis. Huang, J.C., Papasakelariou, C., Dawood, M.Y. Fertil. Steril. (1996) [Pubmed]
  18. The effect of routine breast examination on serum prolactin levels. Hammond, K.R., Steinkampf, M.P., Boots, L.R., Blackwell, R.E. Fertil. Steril. (1996) [Pubmed]
  19. Progesterone levels on the day of human chorionic gonadotropin do not predict pregnancy outcome from the transfer of fresh or cryopreserved embryos from the same cohort. Moffitt, D.V., Queenan, J.T., Shaw, R., Muasher, S.J. Fertil. Steril. (1997) [Pubmed]
  20. SI units of TDF. Orton, C.G. The British journal of radiology. (1980) [Pubmed]
  21. Standardization of steroid immunoassays--in theory an easy task. Thienpont, L.M. Clin. Chem. Lab. Med. (1998) [Pubmed]
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