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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

ICAM-3 expression on endothelium in lymphoid malignancy.

Intercellular adhesion molecule-3 (ICAM-3), the third receptor for lymphocyte function-associated antigen molecule-1 and a new member of the immunoglobulin superfamily has been recently characterized using specific monoclonal antibodies. In the present study, we show immunocytochemically that ICAM-3 is present on T and B cells in the mantle zones and on a subpopulation of follicular center cells in reactive lymph nodes and only occasionally in endothelium. In 52 cases of Hodgkin's disease, ICAM-3, although present on the majority of the reactive lymphoid cells, was absent from the Reed-Sternberg cells and their variants. However, in 28 cases (54%), there was prominent endothelial staining in small vessels. Similar findings were noted in 16 out of 49 cases (33%) of non-Hodgkin's lymphomas. This finding suggests that analogous to ICAM-1 and ICAM-2, ICAM-3 expression can be induced on endothelial cells in lymphoid neoplasms, probably by an as yet unidentified cytokine-mediated mechanism.[1]


  1. ICAM-3 expression on endothelium in lymphoid malignancy. Doussis-Anagnostopoulou, I., Kaklamanis, L., Cordell, J., Jones, M., Turley, H., Pulford, K., Simmons, D., Mason, D., Gatter, K. Am. J. Pathol. (1993) [Pubmed]
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