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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fasciaform myringoplasty in children.

OBJECTIVE: To evaluate the efficacy of fasciaform myringoplasty as a means to repair large tympanic membrane perforations in children. DESIGN: Retrospective review of the records of 26 patients who underwent 29 consecutive fasciaform myringoplasty surgeries over a 47-month period. Patients were followed up from 2 to 47 months postoperatively. SETTING: Academic tertiary care children's hospital. PARTICIPANTS: Twenty-six patients (5 to 16 years old), with tympanic membrane perforations (25% to 95%) underwent a fasciaform myringoplasty procedure. The perforations were caused by extrusion of ventilation tubes (83%), deep retraction pockets, trauma, or repair after resection of cholesteatoma. INTERVENTION: The surgery involves resection of the native tympanic membrane and annulus. A new tympanic membrane is formed from formaldehyde-fixed autogenous temporalis fascia and positioned. OUTCOME MEASURE: Successful repairs, complications, and audiometric evaluations were analyzed. Fisher's Exact Test was used to compare complication rates by age. RESULTS: Successful closure was accomplished in 69% of cases. Otitis media recurred in 52%. Ventilation tubes were reinserted in 24%; 28% resolved with antibiotics alone. When tubes were placed through the graft, small residual graft perforations resulted. Audiometric evaluation revealed improvement in pure tone average to less than a 20-dB hearing level in 77% and reduction of the air-bone gap to within a 20-dB hearing level in 90% of those cases (10/29) with complete audiometric data. CONCLUSIONS: Fasciaform myringoplasty has proven to be a successful procedure for closing large tympanic defects and improving hearing acuity in the pediatric population. However, recurrent otitis media and eustachian tube dysfunction may continue. Rates of reperforation were statistically significantly higher in children 7 years old and younger. Conservative management of children in this younger age group is warranted.[1]


  1. Fasciaform myringoplasty in children. MacDonald, R.R., Lusk, R.P., Muntz, H.R. Arch. Otolaryngol. Head Neck Surg. (1994) [Pubmed]
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