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MeSH Review

Tympanic Membrane

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Disease relevance of Tympanic Membrane


High impact information on Tympanic Membrane

  • RESULTS: Mean rectal temperatures exceeded concurrent oral readings by 0.4 degrees C +/- 0.4 degrees C (0.8 degrees F +/- 0.7 degrees F), which, in turn, exceeded concurrent tympanic membrane readings (obtained with a digital thermometer [IVAC Corp, San Diego, Calif]) by 0.4 degrees C +/- 1.1 degrees C (0.7 degrees F +/- 2.0 degrees F) [6].
  • The noninvasive measurement of tympanic membrane glucose concentration was calibrated to the serum glucose concentration using 432 paired measurements from 20 subjects with insulin-requiring diabetes [7].
  • METHODS: Two-hundred twenty consecutively admitted neuro-ICU patients whose tympanic membrane temperature reached or exceeded 101 degrees F (38.3 degrees C) were randomly assigned to receive acetaminophen (650 mg every 4 hours) alone (n = 107) or acetaminophen plus air blanket therapy (n = 113) [8].
  • Some limited evidence of improvement in patients with rheumatoid arthritis, and a possible healing effect of hyaluronic acid on tympanic membrane perforations, represent additional areas of interest for future investigation [9].
  • Also at day 28, signs of AOM, such as abnormal reflectometry (45% versus 59%; P = 0.017), bulging of the eardrum (10% versus 16%; P = 0.059) and loss of tympanic membrane landmarks (11% versus 22%; P = 0.010) were seen less frequently in azithromycin- than co-amoxiclav-treated children, respectively [10].

Chemical compound and disease context of Tympanic Membrane


Biological context of Tympanic Membrane


Anatomical context of Tympanic Membrane


Associations of Tympanic Membrane with chemical compounds

  • RESULTS: Tympanic membrane temperature during surgery in the patients premedicated with famotidine was significantly less than those in the patients without famotidine [25].
  • METHODS AND MAIN RESULTS: Alfentanil significantly reduced the febrile response to pyrogen, decreasing integrated tympanic membrane temperatures from 7.5+/-2.2 degrees C x hr on the control day, to 4.9+/-1.5 degrees C x hr with 100 ng/mL alfentanil, and to 5.1+/-1.7 degrees C x hr with 200 ng/mL alfentanil (p = .011) [26].
  • In this study, the distribution of hyaluronan (HYA), fibronectin, and five chondroitin sulfate glycosaminoglycans (GAGs) was analysed in healing tympanic membrane (TM) perforations of rats, at different time points, using a HYA-binding protein probe and six monoclonal antibodies (MAbs) [27].
  • The 17 patients, aged 22 to 63 years, had small, medium, or large perforations of the tympanic membrane that were treated locally with sodium hyaluronate until a reduction in the area of the perforation was observed [28].
  • CONCLUSION: Application of docusate sodium or triethanolamine polypeptide did not significantly improve the proportion of tympanic membranes that were completely visualized vs application of the saline control [29].

Gene context of Tympanic Membrane


Analytical, diagnostic and therapeutic context of Tympanic Membrane


  1. Comparison of concentrations of amoxicillin and ampicillin in serum and middle ear fluid of children with chronic otitis media. Klimek, J.J., Nightingale, C., Lehmann, W.B., Quintiliani, R. J. Infect. Dis. (1977) [Pubmed]
  2. Malleal processus brevis is dispensable for normal hearing in mice. Zhang, Z., Zhang, X., Avniel, W.A., Song, Y., Jones, S.M., Jones, T.A., Fermin, C., Chen, Y. Dev. Dyn. (2003) [Pubmed]
  3. Hearing thresholds and tympanic membrane sequelae in children managed medically or surgically for otitis media with effusion. Stenstrom, R., Pless, I.B., Bernard, P. Archives of pediatrics & adolescent medicine. (2005) [Pubmed]
  4. Alternative indications for laser-assisted tympanic membrane fenestration. Cook, S.P., Deutsch, E.S., Reilly, J.S. Lasers in surgery and medicine. (2001) [Pubmed]
  5. Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications. Albino, A.P., Reed, J.A., Bogdany, J.K., Sassoon, J., Desloge, R.B., Parisier, S.C. The American journal of otology. (1998) [Pubmed]
  6. Effects of anatomic site, oral stimulation, and body position on estimates of body temperature. Rabinowitz, R.P., Cookson, S.T., Wasserman, S.S., Mackowiak, P.A. Arch. Intern. Med. (1996) [Pubmed]
  7. A novel noninvasive blood glucose monitor. Malchoff, C.D., Shoukri, K., Landau, J.I., Buchert, J.M. Diabetes Care (2002) [Pubmed]
  8. Clinical trial of an air-circulating cooling blanket for fever control in critically ill neurologic patients. Mayer, S., Commichau, C., Scarmeas, N., Presciutti, M., Bates, J., Copeland, D. Neurology (2001) [Pubmed]
  9. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Goa, K.L., Benfield, P. Drugs (1994) [Pubmed]
  10. Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media. Dunne, M.W., Latiolais, T., Lewis, B., Pistorius, B., Bottenfield, G., Moore, W.H., Garrett, A., Stewart, T.D., Aoki, J., Spiegel, C., Boettger, D., Shemer, A. J. Antimicrob. Chemother. (2003) [Pubmed]
  11. Effect of intratympanic steroid application on the development of experimental cholesteatoma. Sennaroglu, L., Ozkul, A., Gedikoglu, G., Turan, E. Laryngoscope (1998) [Pubmed]
  12. Tympanostomy tubes in children with hemophilia A. Liston, S.L., Berlinger, N., Edson, J.R., Hasegawa, D.K. Laryngoscope (1984) [Pubmed]
  13. Experimental applications of porous (coralline) hydroxylapatite in middle ear and mastoid reconstruction. Jahn, A.F. Laryngoscope (1992) [Pubmed]
  14. Office-based CO2 laser-assisted tympanic membrane fenestration addressing otitis media with effusion. Garin, P., Ledeghen, S., Van Prooyen-Keyser, S., Remacle, M. Journal of clinical laser medicine & surgery. (2001) [Pubmed]
  15. Tympanic membrane displacement analyser tracing modifications induced by glycerol in Menière's disease. Albera, R., Cavalot, A., Musto, R., Fadda, G.L., Staffieri, A., Di Girolamo, S. Audiology (2001) [Pubmed]
  16. Isoflurane-induced vasodilation minimally increases cutaneous heat loss. Sessler, D.I., McGuire, J., Moayeri, A., Hynson, J. Anesthesiology (1991) [Pubmed]
  17. The effects of keratinocyte growth factor on healing of tympanic membrane perforations. Clymer, M.A., Schwaber, M.K., Davidson, J.M. Laryngoscope (1996) [Pubmed]
  18. In vivo capillary diameters in the stria vascularis and spiral ligament of the guinea pig cochlea. Miles, F.P., Nuttall, A.L. Hear. Res. (1988) [Pubmed]
  19. N-chlorotaurine, a novel endogenous antimicrobial agent: tolerability testing in a mouse model. Neher, A., Nagl, M., Schrott-Fischer, A., Ichiki, H., Gottardi, W., Gunkel, A.R., Stephan, K. Arch. Otolaryngol. Head Neck Surg. (2001) [Pubmed]
  20. Epidermal cell migration and healing of the tympanic membrane: an immunohistochemical study of cell proliferation using bromodeoxyuridine labeling. Koba, R. The Annals of otology, rhinology, and laryngology. (1995) [Pubmed]
  21. Fasciaform myringoplasty in children. MacDonald, R.R., Lusk, R.P., Muntz, H.R. Arch. Otolaryngol. Head Neck Surg. (1994) [Pubmed]
  22. Functional/metabolic modulation of the brain stem lesions caused by 1,3-dinitrobenzene in the rat. Ray, D.E., Brown, A.W., Cavanagh, J.B., Nolan, C.C., Richards, H.K., Wylie, S.P. Neurotoxicology (1992) [Pubmed]
  23. Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. Karlidağ, T., Ilhan, N., Kaygusuz, I., Keleş, E., Yalçin, S. Laryngoscope (2004) [Pubmed]
  24. Degranulation of mast cells provokes a massive inflammatory reaction in the tympanic membrane. Eriksson, P.O., Hellström, S. Laryngoscope (2001) [Pubmed]
  25. Premedication with famotidine augments core hypothermia during general anesthesia. Hirose, M., Hara, Y., Matsusaki, M. Anesthesiology (1995) [Pubmed]
  26. Alfentanil reduces the febrile response to interleukin-2 in humans. Negishi, C., Kim, J.S., Lenhardt, R., Sessler, D.I., Ozaki, M., Vuong, K., Bastanmehr, H., Bjorksten, A.R. Crit. Care Med. (2000) [Pubmed]
  27. Extracellular matrix components reflect the dynamics of a healing tympanic membrane perforation--a histochemical study. Laurent, C., Hellström, S. Int. J. Biochem. Cell Biol. (1997) [Pubmed]
  28. Sodium hyaluronate in the repair of perforations of the tympanic membrane. Camarda, V., Cervellini, M., Pedace, G., Pace, M. Clinical therapeutics. (1989) [Pubmed]
  29. Randomized clinical trial of docusate, triethanolamine polypeptide, and irrigation in cerumen removal in children. Whatley, V.N., Dodds, C.L., Paul, R.I. Archives of pediatrics & adolescent medicine. (2003) [Pubmed]
  30. A new method for closing tympanic membrane perforations using basic fibroblast growth factor. Hakuba, N., Taniguchi, M., Shimizu, Y., Sugimoto, A., Shinomori, Y., Gyo, K. Laryngoscope (2003) [Pubmed]
  31. Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media. Raustyte, G., Cayé-Thomasen, P., Hermansson, A., Andersen, H., Thomsen, J. Int. J. Pediatr. Otorhinolaryngol. (2006) [Pubmed]
  32. Office-based insertion of pressure equalization tubes: the role of laser-assisted tympanic membrane fenestration. Brodsky, L., Brookhauser, P., Chait, D., Reilly, J., Deutsch, E., Cook, S., Waner, M., Shaha, S., Nauenberg, E. Laryngoscope (1999) [Pubmed]
  33. Vitamin e-coated tympanostomy tube insertion decreases the quantity of free radicals in tympanic membrane. Uneri, C., Sari, M., Akboğa, J., Yüksel, M. Laryngoscope (2006) [Pubmed]
  34. Adenoidectomy with laser or incisional myringotomy for otitis media with effusion. Szeremeta, W., Parameswaran, M.S., Isaacson, G. Laryngoscope (2000) [Pubmed]
  35. Homograft tympanoplasty in perspective. A long-term clinical-histologic study of formalin-fixed tympanic membranes used for the reconstruction of 125 severely damaged middle ears. Lesinski, S.G. Laryngoscope (1983) [Pubmed]
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