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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Stimulation of B lymphocytes by lipopolysaccharides from anaerobic bacteria.

Lipopolysaccharides (LPSs) from anaerobic gram-negative bacteria, including those of low endotoxic activity that are isolated from Bacteroides, Prevotella, and Porphyromonas are potent inducers of DNA replication and polyclonal immunoglobulin production in murine B lymphocytes. The activation is dose-dependent and T cell-independent. Replication of DNA and production of immunoglobulins were also stimulated by lipid A and by the LPS heteropolysaccharide that were isolated by mild acid hydrolysis of the LPSs of Bacteroides fragilis and Fusobacterium nucleatum. Combinations of LPS, lipid A, and acid-degraded polysaccharide amplified the blastogenic response. Antibodies that react with the polysaccharide part of LPSs isolated from members of the Bacteroidaceae are present in healthy human serum.[1]


  1. Stimulation of B lymphocytes by lipopolysaccharides from anaerobic bacteria. Hofstad, T., Skaug, N., Sveen, K. Clin. Infect. Dis. (1993) [Pubmed]
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