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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.

The involvement of serine/threonine protein phosphatases in signaling pathways which modulate the activity of the transcription factor AP-1 was examined. Purified protein phosphatase types 1 (PP1) and 2A (PP2A) were microinjected into cell lines containing stably transfected lacZ marker genes under the control of an enhancer recognized by AP-1. Microinjection of PP2A potentiated serum-stimulated beta-galactosidase expression from the AP-1-regulated promoter. Similarly, transient expression of the PP2A catalytic subunit with c-Jun resulted in a synergistic transactivation of an AP-1-regulated reporter gene. PP2A, but not PP1, potentiated serum-induced c-Jun expression, which has been previously shown to be autoregulated by AP-1 itself. Consistent with these results, PP2A dephosphorylated c-Jun on negative regulatory sites in vitro, suggesting one possible direct mechanism for the effects of PP2A on AP-1 activity. Microinjection of PP2A had no effect on cyclic AMP (cAMP)-induced expression of a reporter gene containing a cAMP-regulated promoter, while PP1 injection abolished cAMP-induced gene expression. Taken together, these results suggest a specific role for PP2A in signal transduction pathways that regulate AP-1 activity and c-Jun expression.[1]


  1. Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Alberts, A.S., Deng, T., Lin, A., Meinkoth, J.L., Schönthal, A., Mumby, M.C., Karin, M., Feramisco, J.R. Mol. Cell. Biol. (1993) [Pubmed]
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