- The sigma ligand SR 31747 prevents the development of acute graft-versus-host disease in mice by blocking IFN-gamma and GM-CSF mRNA expression. Carayon, P., Bouaboula, M., Loubet, J.F., Bourrie, B., Petitpretre, G., Le Fur, G., Casellas, P. Int. J. Immunopharmacol. (1995)