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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice.

We investigated the effects of the potent somatostatin analog RC-160 on the growth of human osteosarcoma cell lines SK-ES-1 and MNNG/ HOS, transplanted into nude mice or cultured in vitro. Growth of SK-ES-1 and MNNG/ HOS tumors in nude mice was significantly inhibited after 4 weeks of treatment with daily s.c. injections of 100 micrograms RC-160, as measured by a reduction in tumor volume and weight. Histologically, the number of mitotic cells was decreased in the groups treated with RC-160. In mice bearing either tumor model, administration of RC-160 significantly decreased serum growth hormone and insulin-like growth factor I (IGF-I) levels. Specific high-affinity receptors for somatostatin and epidermal growth factor were found on membranes of MNNG/ HOS tumors but not on SK-ES-1 tumors. Receptor analyses also demonstrated high-affinity binding sites for IGF-I on membranes of both tumors. In cell cultures, the proliferation rate of MNNG/ HOS cells, but not of SK-ES-1, was significantly suppressed by RC-160. Our findings demonstrate that RC-160 can significantly inhibit the growth of SK-ES-1 and MNNG/ HOS osteosarcomas in mice.[1]


  1. Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice. Pinski, J., Schally, A.V., Halmos, G., Szepeshazi, K., Groot, K. Int. J. Cancer (1996) [Pubmed]
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