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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The neuronal intermediate filament, alpha-internexin is transiently expressed in amacrine cells in the developing mouse retina.

We have investigated the expression of intermediate filament proteins in the developing mouse retina by immunohistochemistry. Antibodies against alpha-internexin, the three neurofilament subunits (NF-L, NF-M, NF-H), vimentin, and glial fibrillary acidic protein (GFAP) were used to determine the relative expression of these proteins at different post-natal stages of mouse retinal development. alpha-Internexin is widely distributed in the process of amacrine cells, horizontal cells and retinal ganglion cells before post-natal day 5 (P5). At this age, NF-L and NF-M are detected primarily in the processes of horizontal cells and retinal ganglion cells, but are rarely found in amacrine cell processes. After P5, alpha-internexin is found to colocalize with other neuronal intermediate filaments in the cell processes of horizontal and ganglion cells, but its expression is barely detectable in amacrine cells processes. NF-H is not encountered in either the horizontal cell processes or the ganglion nerve fibers until P5. Vimentin is present in all glial cells (astrocytes and Müller cells) and some horizontal cell processes during development, while GFAP is found only in astrocyte processes of the mature retina. The transient presence of alpha-internexin in amacrine cells only in early development suggests that the protein may play a role in the plasticity of neuronal connections in the retina.[1]


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