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Gene Review

Gfap  -  glial fibrillary acidic protein

Mus musculus

Synonyms: AI836096, GFAP, Glial fibrillary acidic protein
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Disease relevance of Gfap


Psychiatry related information on Gfap


High impact information on Gfap


Chemical compound and disease context of Gfap


Biological context of Gfap


Anatomical context of Gfap


Associations of Gfap with chemical compounds


Co-localisations of Gfap


Regulatory relationships of Gfap


Other interactions of Gfap

  • These findings strongly implicate the LIF family of cytokines in the regulation of astrocyte differentiation and indeed the LIF-deficient animals show a significant reduction in the number of GFAP cells in the hippocampus [38].
  • These findings support the in vivo findings that show extremely low levels of GFAP mRNA in brains of embryonic day 19 LIFR-/- mice [38].
  • We used mice with targeted mutations in the GFAP or vimentin genes, or both, to study the impact of loss of either or both of these proteins on intermediate filament formation in cultured astrocytes and in normal or reactive astrocytes in vivo [39].
  • Our findings demonstrate that neither apoE nor GFAP participates in the pathogenesis of the disease or in the production of PrPSc [3].
  • In adult mice, all enteric neurons (labeled with neuron-specific enolase antibodies), and a subpopulation of glial cells (labeled with GFAP antibodies), showed immunoreactivity to Phox2b [40].

Analytical, diagnostic and therapeutic context of Gfap


  1. Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally. Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Berthold, C.H., Westermark, B., Betsholtz, C. EMBO J. (1995) [Pubmed]
  2. Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. Liedtke, W., Edelmann, W., Chiu, F.C., Kucherlapati, R., Raine, C.S. Am. J. Pathol. (1998) [Pubmed]
  3. Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein. Tatzelt, J., Maeda, N., Pekny, M., Yang, S.L., Betsholtz, C., Eliasson, C., Cayetano, J., Camerino, A.P., DeArmond, S.J., Prusiner, S.B. Neurology (1996) [Pubmed]
  4. Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Shu, Q., Antalffy, B., Su, J.M., Adesina, A., Ou, C.N., Pietsch, T., Blaney, S.M., Lau, C.C., Li, X.N. Clin. Cancer Res. (2006) [Pubmed]
  5. Fluoro-Jade((R)) B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Damjanac, M., Bilan, A.R., Barrier, L., Pontcharraud, R., Anne, C., Hugon, J., Page, G. Brain Res. (2007) [Pubmed]
  6. Enhanced spontaneous locomotor activity in bovine GH transgenic mice involves peripheral mechanisms. Bohlooly-Y, M., Olsson, B., Gritli-Linde, A., Brusehed, O., Isaksson, O.G., Ohlsson, C., Söderpalm, B., Törnell, J., Ola, B. Endocrinology (2001) [Pubmed]
  7. Variations in prion protein and glial fibrillary acidic protein mRNAs in the brain of scrapie-infected newborn mouse. Lazarini, F., Deslys, J.P., Dormont, D. J. Gen. Virol. (1992) [Pubmed]
  8. The process of reinnervation in the dentate gyrus of adult rats: temporal relationship between changes in the levels of glial fibrillary acidic protein (GFAP) and GFAP mRNA in reactive astrocytes. Steward, O., Kelley, M.S., Torre, E.R. Exp. Neurol. (1993) [Pubmed]
  9. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Bush, T.G., Savidge, T.C., Freeman, T.C., Cox, H.J., Campbell, E.A., Mucke, L., Johnson, M.H., Sofroniew, M.V. Cell (1998) [Pubmed]
  10. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Schönrich, G., Kalinke, U., Momburg, F., Malissen, M., Schmitt-Verhulst, A.M., Malissen, B., Hämmerling, G.J., Arnold, B. Cell (1991) [Pubmed]
  11. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Liu, X., Wang, Q., Haydar, T.F., Bordey, A. Nat. Neurosci. (2005) [Pubmed]
  12. Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain. Schneider, J.S., Denaro, F.J. J. Neuropathol. Exp. Neurol. (1988) [Pubmed]
  13. Lithium ameliorates HIV-gp120-mediated neurotoxicity. Everall, I.P., Bell, C., Mallory, M., Langford, D., Adame, A., Rockestein, E., Masliah, E. Mol. Cell. Neurosci. (2002) [Pubmed]
  14. Cell growth suppression of astrocytoma C6 cells by glial fibrillary acidic protein cDNA transfection. Toda, M., Miura, M., Asou, H., Toya, S., Uyemura, K. J. Neurochem. (1994) [Pubmed]
  15. Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies. Jean Harry, G., Bruccoleri, A., Lefebvre d'Hellencourt, C. J. Neurosci. Res. (2003) [Pubmed]
  16. Chronic treatment with supraphysiological levels of corticosterone enhances D-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse. Johnson, E.A., O'Callaghan, J.P., Miller, D.B. Brain Res. (2002) [Pubmed]
  17. Recent evolutionary origin of the expression of the glial fibrillary acidic protein (GFAP) in lens epithelial cells. A molecular and genetic analysis of various mouse species. Boyer, S., Montagutelli, X., Gomès, D., Simon-Chazottes, D., Guénet, J.L., Dupouey, P. Brain Res. Mol. Brain Res. (1991) [Pubmed]
  18. Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17. Zimdahl, H., Kreitler, T., Gösele, C., Ganten, D., Hübner, N. Hypertension (2002) [Pubmed]
  19. c-erbA and v-erbA modulate growth and gene expression of a mouse glial precursor cell line. Iglesias, T., Llanos, S., López-Barahona, M., Pérez-Aranda, A., Rodríguez-Peña, A., Bernal, J., Höhne, A., Seliger, B., Muñoz, A. Cell Growth Differ. (1994) [Pubmed]
  20. Krypton laser photocoagulation induces retinal vascular remodeling rather than choroidal neovascularization. Behar-Cohen, F., Benezra, D., Soubrane, G., Jonet, L., Jeanny, J.C. Exp. Eye Res. (2006) [Pubmed]
  21. Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Gomi, H., Yokoyama, T., Fujimoto, K., Ikeda, T., Katoh, A., Itoh, T., Itohara, S. Neuron (1995) [Pubmed]
  22. Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. McCall, M.A., Gregg, R.G., Behringer, R.R., Brenner, M., Delaney, C.L., Galbreath, E.J., Zhang, C.L., Pearce, R.A., Chiu, S.Y., Messing, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  23. Hematopoietic progenitors express neural genes. Goolsby, J., Marty, M.C., Heletz, D., Chiappelli, J., Tashko, G., Yarnell, D., Fishman, P.S., Dhib-Jalbut, S., Bever, C.T., Pessac, B., Trisler, D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  24. Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. Lundkvist, A., Reichenbach, A., Betsholtz, C., Carmeliet, P., Wolburg, H., Pekny, M. J. Cell. Sci. (2004) [Pubmed]
  25. Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments. Levin-Allerhand, J., McEwen, B.S., Lominska, C.E., Lubahn, D.B., Korach, K.S., Smith, J.D. J. Neurochem. (2001) [Pubmed]
  26. Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Araki, T., Muramatsu, Y., Tanaka, K., Matsubara, M., Imai, Y. Neurosci. Lett. (2001) [Pubmed]
  27. Time dependent alterations of co-localization of S100beta and GFAP in the MPTP-treated mice. Himeda, T., Watanabe, Y., Tounai, H., Hayakawa, N., Kato, H., Araki, T. Journal of neural transmission (Vienna, Austria : 1996) (2006) [Pubmed]
  28. An attempt to generate neurons from an astrocyte progenitor cell line FBD-104. Horiuchi, M., Tomooka, Y. Neurosci. Res. (2005) [Pubmed]
  29. Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo? Sriram, K., Benkovic, S.A., Hebert, M.A., Miller, D.B., O'Callaghan, J.P. J. Biol. Chem. (2004) [Pubmed]
  30. Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta. Zhou, H., Hughes, D.E., Major, M.L., Yoo, K., Pesold, C., Costa, R.H. Gene Expr. (2001) [Pubmed]
  31. Regulation of FLRG expression in rat primary astroglial cells and injured brain tissue by transforming growth factor-beta 1 (TGF-beta 1). Zhang, G., Ohsawa, Y., Kametaka, S., Shibata, M., Waguri, S., Uchiyama, Y. J. Neurosci. Res. (2003) [Pubmed]
  32. Expression of aquaporin water channels in mouse spinal cord. Oshio, K., Binder, D.K., Yang, B., Schecter, S., Verkman, A.S., Manley, G.T. Neuroscience (2004) [Pubmed]
  33. Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Pringle, N.P., Yu, W.P., Howell, M., Colvin, J.S., Ornitz, D.M., Richardson, W.D. Development (2003) [Pubmed]
  34. Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. Bennett, M.R., Rizvi, T.A., Karyala, S., McKinnon, R.D., Ratner, N. J. Neurosci. (2003) [Pubmed]
  35. Developmental expression of glial fibrillary acidic protein and glutamine synthetase mRNAs in normal and jimpy mice. Li, X.S., Bartlett, W.P. Brain Res. Mol. Brain Res. (1991) [Pubmed]
  36. Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice. Wei, L.C., Shi, M., Chen, L.W., Cao, R., Zhang, P., Chan, Y.S. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  37. Isolation of cystatin C via functional cloning of astrocyte differentiation factors. Kumada, T., Hasegawa, A., Iwasaki, Y., Baba, H., Ikenaka, K. Dev. Neurosci. (2004) [Pubmed]
  38. Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor. Koblar, S.A., Turnley, A.M., Classon, B.J., Reid, K.L., Ware, C.B., Cheema, S.S., Murphy, M., Bartlett, P.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  39. Intermediate filament protein partnership in astrocytes. Eliasson, C., Sahlgren, C., Berthold, C.H., Stakeberg, J., Celis, J.E., Betsholtz, C., Eriksson, J.E., Pekny, M. J. Biol. Chem. (1999) [Pubmed]
  40. A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture. Young, H.M., Hearn, C.J., Ciampoli, D., Southwell, B.R., Brunet, J.F., Newgreen, D.F. Dev. Biol. (1998) [Pubmed]
  41. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. Mori, T., Wang, X., Jung, J.C., Sumii, T., Singhal, A.B., Fini, M.E., Dixon, C.E., Alessandrini, A., Lo, E.H. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  42. Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse. Kumari, R., Willing, L.B., Krady, J.K., Vannucci, S.J., Simpson, I.A. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  43. Characterization of epidermal neural crest stem cell (EPI-NCSC) grafts in the lesioned spinal cord. Sieber-Blum, M., Schnell, L., Grim, M., Hu, Y.F., Schneider, R., Schwab, M.E. Mol. Cell. Neurosci. (2006) [Pubmed]
  44. Lead alters the immunogenicity of two neural proteins: a potential mechanism for the progression of lead-induced neurotoxicity. Waterman, S.J., el-Fawal, H.A., Snyder, C.A. Environ. Health Perspect. (1994) [Pubmed]
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