Gene Review:
Nefh - neurofilament, heavy polypeptide
Mus musculus
Synonyms:
200 kDa neurofilament protein, Kiaa0845, NEFH, NF-H, NF200, ...
- The neuronal intermediate filament, alpha-internexin is transiently expressed in amacrine cells in the developing mouse retina. Chien, C.L., Liem, R.K. Exp. Eye Res. (1995)
- Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Côté, F., Collard, J.F., Julien, J.P. Cell (1993)
- Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Couillard-Després, S., Zhu, Q., Wong, P.C., Price, D.L., Cleveland, D.W., Julien, J.P. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro. Schwartz, M.L., Katagi, C., Bruce, J., Schlaepfer, W.W. J. Biol. Chem. (1994)
- Neurobehavioral characteristics of mice with modified intermediate filament genes. Lalonde, R., Strazielle, C. Reviews in the neurosciences. (2003)
- Neuroaxonal dystrophy in experimental Creutzfeldt-Jakob disease: electron microscopical and immunohistochemical demonstration of neurofilament accumulations within affected neurites. Liberski, P.P., Budka, H., Yanagihara, R., Gajdusek, D.C. J. Comp. Pathol. (1995)
- Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Collard, J.F., Côté, F., Julien, J.P. Nature (1995)
- Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein. Eyer, J., Peterson, A. Neuron (1994)
- The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. Rao, M.V., Campbell, J., Yuan, A., Kumar, A., Gotow, T., Uchiyama, Y., Nixon, R.A. J. Cell Biol. (2003)
- Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. Xia, C.H., Roberts, E.A., Her, L.S., Liu, X., Williams, D.S., Cleveland, D.W., Goldstein, L.S. J. Cell Biol. (2003)
- Differential expression of neuroD in primary cultures of cerebral cortical neurons. Katayama, M., Mizuta, I., Sakoyama, Y., Kohyama-Koganeya, A., Akagawa, K., Uyemura, K., Ishii, K. Exp. Cell Res. (1997)
- Cyclic AMP-dependent expression of the heavy neurofilament (NF-H) polypeptide in differentiating neuroblastoma cells. Breen, K.C., Anderton, B.H. Brain Res. Mol. Brain Res. (1990)
- Appearance and localization of phosphorylated variants of the high molecular weight neurofilament protein in NB2a/d1 cytoskeletons during differentiation. Shea, T.B., Beermann, M.L., Nixon, R.A. Brain Res. Dev. Brain Res. (1989)
- Requirement of heavy neurofilament subunit in the development of axons with large calibers. Elder, G.A., Friedrich, V.L., Kang, C., Bosco, P., Gourov, A., Tu, P.H., Zhang, B., Lee, V.M., Lazzarini, R.A. J. Cell Biol. (1998)
- Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile. Zhu, Q., Lindenbaum, M., Levavasseur, F., Jacomy, H., Julien, J.P. J. Cell Biol. (1998)
- Methylation and expression of neurofilament genes in tissues and in cell lines of the mouse. Bruce, J., Schwartz, M.L., Shneidman, P.S., Schlaepfer, W.W. Brain Res. Mol. Brain Res. (1993)
- Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. Marszalek, J.R., Williamson, T.L., Lee, M.K., Xu, Z., Hoffman, P.N., Becher, M.W., Crawford, T.O., Cleveland, D.W. J. Cell Biol. (1996)
- cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization. Shetty, K.T., Link, W.T., Pant, H.C. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Antagonistic roles of neurofilament subunits NF-H and NF-M against NF-L in shaping dendritic arborization in spinal motor neurons. Kong, J., Tung, V.W., Aghajanian, J., Xu, Z. J. Cell Biol. (1998)
- Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons. Takeda, S., Okabe, S., Funakoshi, T., Hirokawa, N. J. Cell Biol. (1994)
- High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. Wataya, T., Nunomura, A., Smith, M.A., Siedlak, S.L., Harris, P.L., Shimohama, S., Szweda, L.I., Kaminski, M.A., Avila, J., Price, D.L., Cleveland, D.W., Sayre, L.M., Perry, G. J. Biol. Chem. (2002)
- Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins. Tohda, C., Matsumoto, N., Zou, K., Meselhy, M.R., Komatsu, K. Neuropsychopharmacology (2004)
- Triton-soluble phosphovariants of the high molecular weight neurofilament subunit from NB2a/d1 cells are assembly-competent. Implications for normal and abnormal neurofilament assembly. Shea, T.B. FEBS Lett. (1994)
- Sequence and structure of the mouse gene coding for the largest neurofilament subunit. Julien, J.P., Côté, F., Beaudet, L., Sidky, M., Flavell, D., Grosveld, F., Mushynski, W. Gene (1988)
- Production of monoclonal antibodies against neurofilament-associated proteins: demonstration of association with neurofilaments by a coimmunoprecipitation method. Starr, R., Xiao, J., Monteiro, M.J. J. Neurochem. (1995)
- Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in transfected cells. Bajaj, N.P., Miller, C.C. J. Neurochem. (1997)
- Effects of truncated neurofilament proteins on the endogenous intermediate filaments in transfected fibroblasts. Chin, S.S., Macioce, P., Liem, R.K. J. Cell. Sci. (1991)
- Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. Jacomy, H., Zhu, Q., Couillard-Després, S., Beaulieu, J.M., Julien, J.P. J. Neurochem. (1999)
- Myelin-associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinases. Dashiell, S.M., Tanner, S.L., Pant, H.C., Quarles, R.H. J. Neurochem. (2002)
- Disturbance of hippocampal long-term potentiation after transient ischemia in GFAP deficient mice. Tanaka, H., Katoh, A., Oguro, K., Shimazaki, K., Gomi, H., Itohara, S., Masuzawa, T., Kawai, N. J. Neurosci. Res. (2002)
- Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Bućan, M., Gatalica, B., Nolan, P., Chung, A., Leroux, A., Grossman, M.H., Nadeau, J.H., Emanuel, B.S., Budarf, M. Hum. Mol. Genet. (1993)
- Increased TGFbeta type II receptor expression suppresses the malignant phenotype and induces differentiation of human neuroblastoma cells. Turco, A., Scarpa, S., Coppa, A., Baccheschi, G., Palumbo, C., Leonetti, C., Zupi, G., Colletta, G. Exp. Cell Res. (2000)