Activity of juvenile hormone and juvenile hormone analogues on the growth of Trypanosoma cruzi.
The effects of juvenile hormone-III (JH-III) and the juvenile hormone analogues (JHA) methoprene and fenoxycarb on the growth and macromolecular biosynthesis in Trypanosoma cruzi were studied in vitro. It was observed that JH-III and JHA blocked growth and 3H-thymidine incorporation without killing the cells within certain concentrations (< or = 1 x 10(-4) M), but they caused cellular death at concentrations over 1 x 10(-3) M. The inhibitory effect on growth was partially reversible. On the other hand, the inhibitory action of JH-III, methoprene and fenoxycarb was an unspecific effect according to the results obtained with Leishmania mexicana mexicana (promastigotes) and human peripheral blood lymphocytes. The JHA have a good possibility of being used in the control of trypanosomiasis.[1]References
- Activity of juvenile hormone and juvenile hormone analogues on the growth of Trypanosoma cruzi. Stoka, A.M. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
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