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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain.

We have cloned a cDNA encoding a novel association partner of cyclin G by West-Western blotting. The cDNA encodes a protein that harbors a Ser/Thr protein kinase-like catalytic domain at the N-terminal. Hence, we named it GAK ( cyclin G-associated kinase). The long C-terminal extension shares homology with tensin and auxilin, and contains a leucine zipper region. Co-immunoprecipitation and Western blotting showed that GAK and cyclin G associate together in vivo. GAK also co-precipitated with CDK5, and CDK5 was found to be associated with cyclin G. We also showed by BIAcore analysis that the GAK-cyclin G interaction was direct.[1]


  1. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. Kanaoka, Y., Kimura, S.H., Okazaki, I., Ikeda, M., Nojima, H. FEBS Lett. (1997) [Pubmed]
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