The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CCNG1  -  cyclin G1

Homo sapiens

Synonyms: CCNG, CYCG1, Cyclin-G, Cyclin-G1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CCNG1


High impact information on CCNG1


Chemical compound and disease context of CCNG1


Biological context of CCNG1


Anatomical context of CCNG1

  • Increased expression of cyclin G1 in leiomyoma compared with normal myometrium [10].
  • In the present study, we have analyzed the expression of the cell cycle proteins, CDK2, CDK5 and cyclin G1 in hippocampus and inferior parietal lobule (IPL) in subjects with amnestic mild cognitive impairment and control using Western blot analysis [11].
  • Cyclin G1 is expressed at high levels in skeletal muscle, ovary, and kidney [12].
  • Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct [13].
  • In this study, using a cell line that carries endogenous wild-type p53 genes, we show that transfection of cells with mutant p53, HPV16-E6, or cyclin G transgenes results in the disruption of higher-order chromatin structure, as evidenced by enhanced sensitivity to micrococcal nuclease [14].

Associations of CCNG1 with chemical compounds

  • Cyclin G-overexpressing cells were more sensitive to cisplatin cytotoxicity than the parent cells, probably because cyclin G overexpression overrides cell cycle checkpoint(s) [15].
  • DNA sequencing of the subtracted cDNA pool, cloned into the pBluescript vector, revealed three widely expressed, well known negative growth regulators, namely, thrombospondin 1, cyclin G and tyrosine phosphatase CL100, as primary targets of glucocorticoid hormones [16].
  • We demonstrate cyclic resveratrol-mediated expression of p53, mdm2, p21(cip/waf), Rb, and cyclin G at both the RNA and the protein level at <8 h [17].

Regulatory relationships of CCNG1


Other interactions of CCNG1


Analytical, diagnostic and therapeutic context of CCNG1


  1. Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes. Li, J.Q., Kubo, A., Wu, F., Usuki, H., Fujita, J., Bandoh, S., Masaki, T., Saoo, K., Takeuchi, H., Kobayashi, S., Imaida, K., Maeta, H., Ishida, T., Kuriyama, S. Int. J. Oncol. (2003) [Pubmed]
  2. Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. Skotzko, M., Wu, L., Anderson, W.F., Gordon, E.M., Hall, F.L. Cancer Res. (1995) [Pubmed]
  3. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Gramantieri, L., Ferracin, M., Fornari, F., Veronese, A., Sabbioni, S., Liu, C.G., Calin, G.A., Giovannini, C., Ferrazzi, E., Grazi, G.L., Croce, C.M., Bolondi, L., Negrini, M. Cancer Res. (2007) [Pubmed]
  4. 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Kondo, M., Shibata, T., Kumagai, T., Osawa, T., Shibata, N., Kobayashi, M., Sasaki, S., Iwata, M., Noguchi, N., Uchida, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1. Seo, H.R., Lee, D.H., Lee, H.J., Baek, M., Bae, S., Soh, J.W., Lee, S.J., Kim, J., Lee, Y.S. Cell Death Differ. (2006) [Pubmed]
  6. Regulation of p53 target gene expression by cisplatin-induced extracellular signal-regulated kinase. DeHaan, R.D., Yazlovitskaya, E.M., Persons, D.L. Cancer Chemother. Pharmacol. (2001) [Pubmed]
  7. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. Bates, S., Rowan, S., Vousden, K.H. Oncogene (1996) [Pubmed]
  8. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. Reimer, C.L., Borras, A.M., Kurdistani, S.K., Garreau, J.R., Chung, M., Aaronson, S.A., Lee, S.W. J. Biol. Chem. (1999) [Pubmed]
  9. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. Bennin, D.A., Don, A.S., Brake, T., McKenzie, J.L., Rosenbaum, H., Ortiz, L., DePaoli-Roach, A.A., Horne, M.C. J. Biol. Chem. (2002) [Pubmed]
  10. Increased expression of cyclin G1 in leiomyoma compared with normal myometrium. Baek, W.K., Kim, D., Jung, N., Yi, Y.W., Kim, J.M., Cha, S.D., Bae, I., Cho, C.H. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  11. Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment. Sultana, R., Butterfield, D.A. Neurochem. Res. (2007) [Pubmed]
  12. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. Horne, M.C., Goolsby, G.L., Donaldson, K.L., Tran, D., Neubauer, M., Wahl, A.F. J. Biol. Chem. (1996) [Pubmed]
  13. Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct. Gordon, E.M., Liu, P.X., Chen, Z.H., Liu, L., Whitley, M.D., Gee, C., Groshen, S., Hinton, D.R., Beart, R.W., Hall, F.L. Cancer Res. (2000) [Pubmed]
  14. Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes. Smith, M.L., Bortnick, R.A., Sheikh, M.S., Fornace, A.J. Exp. Cell Res. (1998) [Pubmed]
  15. The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. Smith, M.L., Kontny, H.U., Bortnick, R., Fornace, A.J. Exp. Cell Res. (1997) [Pubmed]
  16. Isolation and characterization of genes associated with the anti-tumor activity of glucocorticoids. Vedoy, C.G., Sogayar, M.C. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  17. Time-dependent resveratrol-mediated mRNA and protein expression associated with cell cycle in WR-21 cells containing mutated human c-Ha-Ras. Young, L.F., Martin, K.R. Molecular nutrition & food research. (2006) [Pubmed]
  18. The negative role of cyclin G in ATM-dependent p53 activation. Ohtsuka, T., Jensen, M.R., Kim, H.G., Kim, K.T., Lee, S.W. Oncogene (2004) [Pubmed]
  19. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. Kanaoka, Y., Kimura, S.H., Okazaki, I., Ikeda, M., Nojima, H. FEBS Lett. (1997) [Pubmed]
  20. A better cell cycle target for gene therapy of colorectal cancer: cyclin G. Perez, R., Wu, N., Klipfel, A.A., Beart, R.W. J. Gastrointest. Surg. (2003) [Pubmed]
  21. Inhibition of cell proliferation in head and neck squamous cell carcinoma cell lines with antisense cyclin D1. Wang, M.B., Billings, K.R., Venkatesan, N., Hall, F.L., Srivatsan, E.S. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1998) [Pubmed]
WikiGenes - Universities