Gene Review:
TNS1 - tensin 1
Homo sapiens
Synonyms:
DKFZp586K0617, MST091, MST122, MST127, MSTP091, ...
Jiang,
Katz,
Chen,
Gutkind,
Walter,
Foy,
Zheng,
Traverso,
Turic,
Lin,
Li,
Matsumoto,
Leslie,
Moore,
Chen,
Aune,
Cao,
Vogelstein,
Lo,
Yamada,
Downes,
Howe,
Wang,
Hamilton,
Knight,
Gray,
Sayed,
Hollingworth,
Williams,
Powell,
Velculescu,
Archer,
Pass,
Owen,
O'Donovan,
Zohar,
Roman,
Samedi,
Han,
Sui,
Anderson,
Petersen,
Espenes,
Lovestone,
Jehu,
Hang,
Lo,
Teramoto,
Hetland,
Mitros,
Orchiston,
Korsnes,
Lin,
Bair,
- PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. Sun, S., Steinberg, B.M. J. Gen. Virol. (2002)
- Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene. Hang, Y., Zheng, Y.C., Cao, Y., Li, Q.S., Sui, Y.J. World J. Gastroenterol. (2005)
- Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. Chen, Q., Wang, C., Jiang, C., Chen, D. J. Huazhong Univ. Sci. Technol. Med. Sci. (2007)
- Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Wong, J.T., Kim, P.T., Peacock, J.W., Yau, T.Y., Mui, A.L., Chung, S.W., Sossi, V., Doudet, D., Green, D., Ruth, T.J., Parsons, R., Verchere, C.B., Ong, C.J. Diabetologia (2007)
- PTEN-deficient intestinal stem cells initiate intestinal polyposis. He, X.C., Yin, T., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L.M., Barrett, T.A., Hood, L., Wu, H., Li, L. Nat. Genet. (2007)
- A role for nuclear PTEN in neuronal differentiation. Lachyankar, M.B., Sultana, N., Schonhoff, C.M., Mitra, P., Poluha, W., Lambert, S., Quesenberry, P.J., Litofsky, N.S., Recht, L.D., Nabi, R., Miller, S.J., Ohta, S., Neel, B.G., Ross, A.H. J. Neurosci. (2000)
- Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M.C., Williams, J., Owen, M.J., Lovestone, S., Powell, J.F. Neurosci. Lett. (2006)
- The use of transdermal nicotine in smoking cessation. Müller, P., Abelin, T., Ehrsam, R., Imhof, P., Howald, H., Mauli, D. Lung (1990)
- Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe, J.R., Bair, J.L., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V.E., Traverso, G., Vogelstein, B. Nat. Genet. (2001)
- Control of actin assembly at filament ends. Schafer, D.A., Cooper, J.A. Annu. Rev. Cell Dev. Biol. (1995)
- Regulation of PTEN by Rho small GTPases. Li, Z., Dong, X., Dong, X., Wang, Z., Liu, W., Deng, N., Ding, Y., Tang, L., Hla, T., Zeng, R., Li, L., Wu, D. Nat. Cell Biol. (2005)
- Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Zamir, E., Katz, M., Posen, Y., Erez, N., Yamada, K.M., Katz, B.Z., Lin, S., Lin, D.C., Bershadsky, A., Kam, Z., Geiger, B. Nat. Cell Biol. (2000)
- Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer. Frattini, M., Signoroni, S., Pilotti, S., Bertario, L., Benvenuti, S., Zanon, C., Bardelli, A., Pierotti, M.A. Cancer Res. (2005)
- A double-blind multiple crossover trial evaluating a transdermal nitroglycerin system vs placebo. Dickstein, K., Knutsen, H. Eur. Heart J. (1985)
- Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. Kim, K.Y., Shin, H.K., Lee, J.H., Kim, C.D., Lee, W.S., Rhim, B.Y., Shin, Y.W., Hong, K.W. J. Pharmacol. Exp. Ther. (2004)
- Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways. Han, S., Roman, J. Mol. Cancer Ther. (2006)
- Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes. Mollet, G., Silbermann, F., Delous, M., Salomon, R., Antignac, C., Saunier, S. Hum. Mol. Genet. (2005)
- A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer. Herlevsen, M., Oxford, G., Ptak, C., Shabanowitz, J., Hunt, D.F., Conaway, M., Theodorescu, D. Biochem. Biophys. Res. Commun. (2007)
- PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Kim, S., Domon-Dell, C., Wang, Q., Chung, D.H., Di Cristofano, A., Pandolfi, P.P., Freund, J.N., Evers, B.M. Gastroenterology (2002)
- PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Dahia, P.L., Aguiar, R.C., Alberta, J., Kum, J.B., Caron, S., Sill, H., Marsh, D.J., Ritz, J., Freedman, A., Stiles, C., Eng, C. Hum. Mol. Genet. (1999)
- Focal adhesion kinase and protein kinase B cooperate to suppress Doxorubicin-induced apoptosis of breast tumor cells. van Nimwegen, M.J., Huigsloot, M., Camier, A., Tijdens, I.B., van de Water, B. Mol. Pharmacol. (2006)
- Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. Freeburn, R.W., Wright, K.L., Burgess, S.J., Astoul, E., Cantrell, D.A., Ward, S.G. J. Immunol. (2002)
- Molecular characterization of human tensin. Chen, H., Ishii, A., Wong, W.K., Chen, L.B., Lo, S.H. Biochem. J. (2000)
- Tensin is potentially involved in extracellular matrix production in mesangial cells. Yamashita, M., Horikoshi, S., Asanuma, K., Takahara, H., Shirato, I., Tomino, Y. Histochem. Cell Biol. (2004)
- PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal. Orchiston, E.A., Bennett, D., Leslie, N.R., Clarke, R.G., Winward, L., Downes, C.P., Safrany, S.T. J. Biol. Chem. (2004)
- A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Nigorikawa, K., Yoshikawa, K., Sasaki, T., Iida, E., Tsukamoto, M., Murakami, H., Maehama, T., Hazeki, K., Hazeki, O. Mol. Pharmacol. (2006)
- Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Leslie, N.R., Gray, A., Pass, I., Orchiston, E.A., Downes, C.P. Biochem. J. (2000)
- Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Qian, X., Li, G., Asmussen, H.K., Asnaghi, L., Vass, W.C., Braverman, R., Yamada, K.M., Popescu, N.C., Papageorge, A.G., Lowy, D.R. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Lo, S.H., Lo, T.B. Cancer Res. (2002)
- Cleavage of tensin during cytoskeleton disruption in YTX-induced apoptosis. Korsnes, M.S., Hetland, D.L., Espenes, A., Aune, T. Toxicology in vitro : an international journal published in association with BIBRA (2007)
- Inhibition of protein kinase B/Akt. implications for cancer therapy. Hill, M.M., Hemmings, B.A. Pharmacol. Ther. (2002)
- Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth. Arevalo, M.A., Rodríguez-Tébar, A. Mol. Biol. Cell (2006)
- Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. Pankov, R., Cukierman, E., Katz, B.Z., Matsumoto, K., Lin, D.C., Lin, S., Hahn, C., Yamada, K.M. J. Cell Biol. (2000)
- The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. Oudit, G.Y., Sun, H., Kerfant, B.G., Crackower, M.A., Penninger, J.M., Backx, P.H. J. Mol. Cell. Cardiol. (2004)
- Tensin can induce JNK and p38 activation. Katz, B.Z., Zohar, M., Teramoto, H., Matsumoto, K., Gutkind, J.S., Lin, D.C., Lin, S., Yamada, K.M. Biochem. Biophys. Res. Commun. (2000)
- Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. Chen, Y., Wang, S.M., Wu, J.C., Huang, S.H. J. Cell. Biochem. (2006)
- Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Kaper, F., Dornhoefer, N., Giaccia, A.J. Cancer Res. (2006)
- Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas. Qiao, J., Kang, J., Cree, J., Evers, B.M., Chung, D.H. Ann. Surg. (2005)
- Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Zhang, H.G., Wang, Y., Xie, J.F., Liang, X., Liu, D., Yang, P., Hsu, H.C., Ray, R.B., Mountz, J.D. Arthritis Rheum. (2001)
- Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes. McNeish, I.A., Bell, S.J., Lemoine, N.R. Gene Ther. (2004)
- Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10. White, E.S., Thannickal, V.J., Carskadon, S.L., Dickie, E.G., Livant, D.L., Markwart, S., Toews, G.B., Arenberg, D.A. Am. J. Respir. Crit. Care Med. (2003)
- Comparative effects of electroacupuncture and transcutaneous nerve stimulation on the human blink reflex. Willer, J.C., Roby, A., Boulu, P., Boureau, F. Pain (1982)