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Gene Review

TNS1  -  tensin 1

Homo sapiens

Synonyms: DKFZp586K0617, MST091, MST122, MST127, MSTP091, ...
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Disease relevance of TNS1

  • This observation was explained by the elevated expression of the phosphatase and tensin homologue (PTEN), a recently characterized tumour suppressor, in papilloma tissue [1].
  • AIM: To investigate the tumor-suppressive effect of the phosphatase and tensin homologue deleted from chromosome (PTEN) in human gastric cancer cells that were wild type for PTEN [2].
  • The effects and mechanisms of exogenous phosphatase and tensin homolog deleted from chromosome ten (PTEN) gene on phosphatase activity-dependent apoptosis of breast cancer cell line MDA468 were investigated [3].
  • Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity [4].
  • In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement [5].

Psychiatry related information on TNS1

  • Mutations of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a protein and lipid phosphatase, have been associated with gliomas, macrocephaly, and mental deficiencies [6].
  • Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease [7].
  • The efficacy of the TNS was investigated in two placebo-controlled double-blind smoking cessation programs with minimal contact and minimal psychological support [8].

High impact information on TNS1

  • However, mutations in MADH4 are only present in a subset of JP cases, and although mutations in the gene for phosphatase and tensin homolog (PTEN) have been described in a few families, undefined genetic heterogeneity remains [9].
  • Proteins that bind to the barbed end, including capping protein, the gelsolin super-family, tensin, and profilin are discussed, as are proteins that bind to the pointed end, including tropomodulin and spectrin/band 4 [10].
  • PTEN (phosphatase and tensin homologue) is a phosphatase that dephosphorylates both protein and phosphoinositide substrates [11].
  • Fibrillar adhesions arise from the medial ends of stationary focal contacts, contain alpha5beta1 integrin and tensin but not other focal-contact components, and associate with fibronectin fibrils [12].
  • Here we use time-lapse microscopy to analyse cell-matrix adhesions in cells expressing one of two different cytoskeletal proteins, paxillin or tensin, tagged with green fluorescent protein (GFP) [12].

Chemical compound and disease context of TNS1


Biological context of TNS1


Anatomical context of TNS1


Associations of TNS1 with chemical compounds


Physical interactions of TNS1


Enzymatic interactions of TNS1


Regulatory relationships of TNS1


Other interactions of TNS1

  • Class I(A) (PI3Kalpha, beta and delta) and class I(B) (PI3Kgamma) PI3Ks mediate distinct phenotypes in the heart and under negative control by the 3'-lipid phosphatase, phosphatase and tensin homolog on chromosome ten (PTEN) which dephosphorylate PtdIns(3,4,5)P(3) into PtdIns(4,5)P(2) [34].
  • We tested whether tensin, a cytoskeletal component localized to both focal contacts and fibronectin-associated fibrillar adhesions, can induce these signaling pathways [35].
  • Furthermore, PPARgamma agonists induced expression of protein tyrosine phosphatase-PEST (PTP-PEST), and of phosphatase and tensin homologue deleted on chromosome ten (PTEN) [36].
  • An important regulatory mechanism of translational repression under hypoxic conditions involves inhibition of the mammalian target of rapamycin (mTOR). mTOR is a target of the phosphatase and tensin homologue detected on chromosome 10 (PTEN)/phosphatidylinositol 3-kinase/AKT/TSC2 pathway, a pathway that is frequently mutated in human cancers [37].
  • Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas [38].

Analytical, diagnostic and therapeutic context of TNS1


  1. PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. Sun, S., Steinberg, B.M. J. Gen. Virol. (2002) [Pubmed]
  2. Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene. Hang, Y., Zheng, Y.C., Cao, Y., Li, Q.S., Sui, Y.J. World J. Gastroenterol. (2005) [Pubmed]
  3. Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. Chen, Q., Wang, C., Jiang, C., Chen, D. J. Huazhong Univ. Sci. Technol. Med. Sci. (2007) [Pubmed]
  4. Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Wong, J.T., Kim, P.T., Peacock, J.W., Yau, T.Y., Mui, A.L., Chung, S.W., Sossi, V., Doudet, D., Green, D., Ruth, T.J., Parsons, R., Verchere, C.B., Ong, C.J. Diabetologia (2007) [Pubmed]
  5. PTEN-deficient intestinal stem cells initiate intestinal polyposis. He, X.C., Yin, T., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L.M., Barrett, T.A., Hood, L., Wu, H., Li, L. Nat. Genet. (2007) [Pubmed]
  6. A role for nuclear PTEN in neuronal differentiation. Lachyankar, M.B., Sultana, N., Schonhoff, C.M., Mitra, P., Poluha, W., Lambert, S., Quesenberry, P.J., Litofsky, N.S., Recht, L.D., Nabi, R., Miller, S.J., Ohta, S., Neel, B.G., Ross, A.H. J. Neurosci. (2000) [Pubmed]
  7. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M.C., Williams, J., Owen, M.J., Lovestone, S., Powell, J.F. Neurosci. Lett. (2006) [Pubmed]
  8. The use of transdermal nicotine in smoking cessation. Müller, P., Abelin, T., Ehrsam, R., Imhof, P., Howald, H., Mauli, D. Lung (1990) [Pubmed]
  9. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe, J.R., Bair, J.L., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V.E., Traverso, G., Vogelstein, B. Nat. Genet. (2001) [Pubmed]
  10. Control of actin assembly at filament ends. Schafer, D.A., Cooper, J.A. Annu. Rev. Cell Dev. Biol. (1995) [Pubmed]
  11. Regulation of PTEN by Rho small GTPases. Li, Z., Dong, X., Dong, X., Wang, Z., Liu, W., Deng, N., Ding, Y., Tang, L., Hla, T., Zeng, R., Li, L., Wu, D. Nat. Cell Biol. (2005) [Pubmed]
  12. Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Zamir, E., Katz, M., Posen, Y., Erez, N., Yamada, K.M., Katz, B.Z., Lin, S., Lin, D.C., Bershadsky, A., Kam, Z., Geiger, B. Nat. Cell Biol. (2000) [Pubmed]
  13. Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer. Frattini, M., Signoroni, S., Pilotti, S., Bertario, L., Benvenuti, S., Zanon, C., Bardelli, A., Pierotti, M.A. Cancer Res. (2005) [Pubmed]
  14. A double-blind multiple crossover trial evaluating a transdermal nitroglycerin system vs placebo. Dickstein, K., Knutsen, H. Eur. Heart J. (1985) [Pubmed]
  15. Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. Kim, K.Y., Shin, H.K., Lee, J.H., Kim, C.D., Lee, W.S., Rhim, B.Y., Shin, Y.W., Hong, K.W. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  16. Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways. Han, S., Roman, J. Mol. Cancer Ther. (2006) [Pubmed]
  17. Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes. Mollet, G., Silbermann, F., Delous, M., Salomon, R., Antignac, C., Saunier, S. Hum. Mol. Genet. (2005) [Pubmed]
  18. A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer. Herlevsen, M., Oxford, G., Ptak, C., Shabanowitz, J., Hunt, D.F., Conaway, M., Theodorescu, D. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  19. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Kim, S., Domon-Dell, C., Wang, Q., Chung, D.H., Di Cristofano, A., Pandolfi, P.P., Freund, J.N., Evers, B.M. Gastroenterology (2002) [Pubmed]
  20. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Dahia, P.L., Aguiar, R.C., Alberta, J., Kum, J.B., Caron, S., Sill, H., Marsh, D.J., Ritz, J., Freedman, A., Stiles, C., Eng, C. Hum. Mol. Genet. (1999) [Pubmed]
  21. Focal adhesion kinase and protein kinase B cooperate to suppress Doxorubicin-induced apoptosis of breast tumor cells. van Nimwegen, M.J., Huigsloot, M., Camier, A., Tijdens, I.B., van de Water, B. Mol. Pharmacol. (2006) [Pubmed]
  22. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. Freeburn, R.W., Wright, K.L., Burgess, S.J., Astoul, E., Cantrell, D.A., Ward, S.G. J. Immunol. (2002) [Pubmed]
  23. Molecular characterization of human tensin. Chen, H., Ishii, A., Wong, W.K., Chen, L.B., Lo, S.H. Biochem. J. (2000) [Pubmed]
  24. Tensin is potentially involved in extracellular matrix production in mesangial cells. Yamashita, M., Horikoshi, S., Asanuma, K., Takahara, H., Shirato, I., Tomino, Y. Histochem. Cell Biol. (2004) [Pubmed]
  25. PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal. Orchiston, E.A., Bennett, D., Leslie, N.R., Clarke, R.G., Winward, L., Downes, C.P., Safrany, S.T. J. Biol. Chem. (2004) [Pubmed]
  26. A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Nigorikawa, K., Yoshikawa, K., Sasaki, T., Iida, E., Tsukamoto, M., Murakami, H., Maehama, T., Hazeki, K., Hazeki, O. Mol. Pharmacol. (2006) [Pubmed]
  27. Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Leslie, N.R., Gray, A., Pass, I., Orchiston, E.A., Downes, C.P. Biochem. J. (2000) [Pubmed]
  28. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Qian, X., Li, G., Asmussen, H.K., Asnaghi, L., Vass, W.C., Braverman, R., Yamada, K.M., Popescu, N.C., Papageorge, A.G., Lowy, D.R. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  29. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Lo, S.H., Lo, T.B. Cancer Res. (2002) [Pubmed]
  30. Cleavage of tensin during cytoskeleton disruption in YTX-induced apoptosis. Korsnes, M.S., Hetland, D.L., Espenes, A., Aune, T. Toxicology in vitro : an international journal published in association with BIBRA (2007) [Pubmed]
  31. Inhibition of protein kinase B/Akt. implications for cancer therapy. Hill, M.M., Hemmings, B.A. Pharmacol. Ther. (2002) [Pubmed]
  32. Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth. Arevalo, M.A., Rodríguez-Tébar, A. Mol. Biol. Cell (2006) [Pubmed]
  33. Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. Pankov, R., Cukierman, E., Katz, B.Z., Matsumoto, K., Lin, D.C., Lin, S., Hahn, C., Yamada, K.M. J. Cell Biol. (2000) [Pubmed]
  34. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. Oudit, G.Y., Sun, H., Kerfant, B.G., Crackower, M.A., Penninger, J.M., Backx, P.H. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  35. Tensin can induce JNK and p38 activation. Katz, B.Z., Zohar, M., Teramoto, H., Matsumoto, K., Gutkind, J.S., Lin, D.C., Lin, S., Yamada, K.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  36. Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. Chen, Y., Wang, S.M., Wu, J.C., Huang, S.H. J. Cell. Biochem. (2006) [Pubmed]
  37. Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Kaper, F., Dornhoefer, N., Giaccia, A.J. Cancer Res. (2006) [Pubmed]
  38. Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas. Qiao, J., Kang, J., Cree, J., Evers, B.M., Chung, D.H. Ann. Surg. (2005) [Pubmed]
  39. Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Zhang, H.G., Wang, Y., Xie, J.F., Liang, X., Liu, D., Yang, P., Hsu, H.C., Ray, R.B., Mountz, J.D. Arthritis Rheum. (2001) [Pubmed]
  40. Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes. McNeish, I.A., Bell, S.J., Lemoine, N.R. Gene Ther. (2004) [Pubmed]
  41. Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10. White, E.S., Thannickal, V.J., Carskadon, S.L., Dickie, E.G., Livant, D.L., Markwart, S., Toews, G.B., Arenberg, D.A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  42. Comparative effects of electroacupuncture and transcutaneous nerve stimulation on the human blink reflex. Willer, J.C., Roby, A., Boulu, P., Boureau, F. Pain (1982) [Pubmed]
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