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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Expression of aquaporins in the rat ocular tissue.

The aquaporins (AQPs) are a rapid growing family of water channel proteins found in animals, plants and microorganisms that raise plasma membrane water permeability required for efficient isosmotic fluid transport. Five homologs of aquaporins (AQP1, AQP2, AQP3, AQP4 and AQP5) have been identified from various mammalian tissues; the expression of these aquaporins in ocular tissues was studied. Semiquantitative expression levels of these aquaporins were determined in ciliary body, cornea, lens, retina, iris and choroid using RT-PCR. Expression levels of AQP1 are highest among the known aquaporins in each rat ocular tissue examined. In cornea, AQP1 is expressed approximately three-fold higher than AQP3 and 2.5 fold higher than AQP5. However, the highest intraocular expressions of AQP3 and AQP5 are in the cornea. In the iris, expression levels of AQP1 are approximately 600-700 fold higher than AQP4 and AQP5. In the ciliary body, the expression levels of AQP1 are approximately ten-fold higher than AQP4, the only other aquaporin expressed. In the lens, the major water channel is AQP1 with detectable levels of AQP4 and AQP5 that are approximately 1000-fold lower than AQP1. In choroid, AQP1 is the only water channel expressed. In retin, AQP1 is expressed approximately six-fold higher than AQP4, the only other aquaporin expressed. However, the highest ocular expression of AQP4 is in retina. AQP2 is not detected in the eye. Finally, the possible physiological roles of aquaporins in maintaining and regulating the aqueous flow, and corneal and lens transparency are discussed.[1]


  1. Expression of aquaporins in the rat ocular tissue. Patil, R.V., Saito, I., Yang, X., Wax, M.B. Exp. Eye Res. (1997) [Pubmed]
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