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Gene Review

Aqp2  -  aquaporin 2 (collecting duct)

Rattus norvegicus

Synonyms: ADH water channel, AQP-2, AQP-CD, Aquaporin-2, Aquaporin-CD, ...
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Disease relevance of Aqp2


Psychiatry related information on Aqp2


High impact information on Aqp2


Chemical compound and disease context of Aqp2


Biological context of Aqp2


Anatomical context of Aqp2


Associations of Aqp2 with chemical compounds


Co-localisations of Aqp2

  • Tubular renin immunostaining was apically distributed in principal cells colocalizing with aquaporin-2 in connecting tubules and cortical and medullary collecting ducts [25].

Regulatory relationships of Aqp2


Other interactions of Aqp2


Analytical, diagnostic and therapeutic context of Aqp2


  1. Reduced renal medullary water channel expression in puromycin aminonucleoside--induced nephrotic syndrome. Apostol, E., Ecelbarger, C.A., Terris, J., Bradford, A.D., Andrews, P., Knepper, M.A. J. Am. Soc. Nephrol. (1997) [Pubmed]
  2. Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Preisser, L., Teillet, L., Aliotti, S., Gobin, R., Berthonaud, V., Chevalier, J., Corman, B., Verbavatz, J.M. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  3. Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Spector, D.A., Wade, J.B., Dillow, R., Steplock, D.A., Weinman, E.J. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  4. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li, C., Wang, W., Knepper, M.A., Nielsen, S., Frøkiaer, J. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  5. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum, L.N., Kwon, T.H., Marples, D., Flyvbjerg, A., Knepper, M.A., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  6. Regulation of aquaporin mRNA expression in rat kidney by water intake. Murillo-Carretero, M.I., Ilundáin, A.A., Echevarria, M. J. Am. Soc. Nephrol. (1999) [Pubmed]
  7. Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation. Wilke, C., Sheriff, S., Soleimani, M., Amlal, H. Kidney Int. (2005) [Pubmed]
  8. Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. Kazama, I., Arata, T., Michimata, M., Hatano, R., Suzuki, M., Miyama, N., Sanada, S., Sato, A., Satomi, S., Ejima, Y., Sasaki, S., Matsubara, M. Nephrol. Dial. Transplant. (2007) [Pubmed]
  9. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Fushimi, K., Uchida, S., Hara, Y., Hirata, Y., Marumo, F., Sasaki, S. Nature (1993) [Pubmed]
  10. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. Bouley, R., Breton, S., Sun, T., McLaughlin, M., Nsumu, N.N., Lin, H.Y., Ausiello, D.A., Brown, D. J. Clin. Invest. (2000) [Pubmed]
  11. Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome. Fernández-Llama, P., Andrews, P., Nielsen, S., Ecelbarger, C.A., Knepper, M.A. Kidney Int. (1998) [Pubmed]
  12. Reverse pharmacological effect of loop diuretics and altered rBSC1 expression in rats with lithium nephropathy. Michimata, M., Fujita, S., Araki, T., Mizukami, K., Kazama, I., Muramatsu, Y., Suzuki, M., Kimura, T., Sasaki, S., Imai, Y., Matsubara, M. Kidney Int. (2003) [Pubmed]
  13. Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats. Kim, S.W., Jeon, Y.S., Lee, J.U., Kang, D.G., Kook, H., Ahn, K.Y., Kim, S.Z., Cho, K.W., Kim, N.H., Han, J.S., Choi, K.C. Kidney Int. (2000) [Pubmed]
  14. Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action. Yu, C.M., Wing-Hon Lai, K., Li, P.S., Lam, K.Y., Leung, J.C., Lai, K.N. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  15. Aquaporin-2 in the immature rat: expression, regulation, and trafficking. Bonilla-Felix, M., Jiang, W. J. Am. Soc. Nephrol. (1997) [Pubmed]
  16. Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney. Russo, L.M., McKee, M., Brown, D. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  17. Administration of oxytocin affects vasopressin V2 receptor and aquaporin-2 gene expression in the rat. Terashima, Y., Kondo, K., Oiso, Y. Life Sci. (1999) [Pubmed]
  18. Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue. Nishimoto, G., Zelenina, M., Li, D., Yasui, M., Aperia, A., Nielsen, S., Nairn, A.C. Am. J. Physiol. (1999) [Pubmed]
  19. Urinary excretion of aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway. Wen, H., Frokiaer, J., Kwon, T.H., Nielsen, S. J. Am. Soc. Nephrol. (1999) [Pubmed]
  20. Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Da Silva, N., Silberstein, C., Beaulieu, V., Piétrement, C., Van Hoek, A.N., Brown, D., Breton, S. Biol. Reprod. (2006) [Pubmed]
  21. Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin-2 in renal epithelial cells. Lorenz, D., Krylov, A., Hahm, D., Hagen, V., Rosenthal, W., Pohl, P., Maric, K. EMBO Rep. (2003) [Pubmed]
  22. Expression of AQP family in rat kidneys during development and maturation. Yamamoto, T., Sasaki, S., Fushimi, K., Ishibashi, K., Yaoita, E., Kawasaki, K., Fujinaka, H., Marumo, F., Kihara, I. Am. J. Physiol. (1997) [Pubmed]
  23. Cisplatin decreases the abundance of aquaporin water channels in rat kidney. Kim, S.W., Lee, J.U., Nah, M.Y., Kang, D.G., Ahn, K.Y., Lee, H.S., Choi, K.C. J. Am. Soc. Nephrol. (2001) [Pubmed]
  24. Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Kwon, T.H., Nielsen, J., Knepper, M.A., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  25. Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Prieto-Carrasquero, M.C., Harrison-Bernard, L.M., Kobori, H., Ozawa, Y., Hering-Smith, K.S., Hamm, L.L., Navar, L.G. Hypertension (2004) [Pubmed]
  26. Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V2 receptor in rat kidney. Hayashi, M., Sasaki, S., Tsuganezawa, H., Monkawa, T., Kitajima, W., Konishi, K., Fushimi, K., Marumo, F., Saruta, T. J. Clin. Invest. (1994) [Pubmed]
  27. Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodine-sensitive Ca2+ stores and calmodulin. Chou, C.L., Yip, K.P., Michea, L., Kador, K., Ferraris, J.D., Wade, J.B., Knepper, M.A. J. Biol. Chem. (2000) [Pubmed]
  28. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. Hadrup, N., Petersen, J.S., Praetorius, J., Meier, E., Graebe, M., Brønd, L., Staahltoft, D., Nielsen, S., Christensen, S., Kapusta, D.R., Jonassen, T.E. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  29. Correlation between cyclosporine-induced nephrotoxicity in reduced nephron mass and expression of kidney injury molecule-1 and aquaporin-2 gene. Hong, M.E., Hong, J.C., Stepkowski, S., Kahan, B.D. Transplant. Proc. (2005) [Pubmed]
  30. Influence of acute elevation of plasma AVP level on rat vasopressin V2 receptor and aquaporin-2 mRNA expression. Terashima, Y., Kondo, K., Mizuno, Y., Iwasaki, Y., Oiso, Y. J. Mol. Endocrinol. (1998) [Pubmed]
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