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Gene Review

Aqp3  -  aquaporin 3

Rattus norvegicus

Synonyms: 31.4 kDa water channel protein, AQP-3, Aquaglyceroporin-3, Aquaporin-3
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Disease relevance of Aqp3


High impact information on Aqp3

  • In contrast, immunoblotting demonstrated a lack of an increase in expression of AQP1 and AQP3 water channel expression, indicating that the effect on AQP2 was selective [6].
  • The present study demonstrates the existence of an additional water channel, AQP3, in epithelial cells of the medullary collecting duct [7].
  • AQP3 did not permit passage of monovalent ions (Na, K, Cl); however, it is slightly permeable to urea [7].
  • Injection of the complementary RNA of AQP3 into Xenopus oocytes markedly increased the osmotic water permeability [7].
  • AQP3 has amino acid sequence identity with major intrinsic protein (MIP) family proteins including AQP-channel-forming integral membrane protein, AQP-collecting duct, MIP, AQP-gamma tonoplast intrinsic protein, nodulin 26, and glycerol facilitator (33-42%) [8].

Chemical compound and disease context of Aqp3


Biological context of Aqp3


Anatomical context of Aqp3


Associations of Aqp3 with chemical compounds

  • Semi-quantitative RT-PCR showed that AQP3 mRNA in the thiourea group rose significantly, peaking at around 4-8 h [12].
  • In conclusion, the results uniformly demonstrate that aldosterone regulates AQP3 abundance independently of Na intake [13].
  • Under these circumstances, there were no changes in AQP3 or AQP2 abundance, although the level of the thiazide-sensitive Na-Cl cotransporter was decreased [13].
  • Whole kidney abundance of AQP3, the bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2), and gamma-ENaC (85-kDa band) correlated most strongly with blood glucose in study 3 [18].
  • The protein expression of AQP1 as well as that of AQP3 was also decreased in the cortex by treatment with the highest dose of gentamicin [19].

Other interactions of Aqp3

  • Aquaporin-2 and aquaporin-3 expression was also markedly diminished in the renal cortex, indicating that the effect is not limited to the inner medullary collecting duct [3].
  • AQP3 and AQP4 mRNA expression was significantly found at birth but was not changed remarkably thereafter [20].
  • Additional cDNA arrays revealed that several transcripts that were increased in abundance after 72 h of dDAVP were also increased after 4 h, including casein kinase IIbeta, beta-ENaC, aquaporin-3, UT-A, and syntaxin 2 [21].

Analytical, diagnostic and therapeutic context of Aqp3


  1. Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Spector, D.A., Wade, J.B., Dillow, R., Steplock, D.A., Weinman, E.J. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  2. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum, L.N., Kwon, T.H., Marples, D., Flyvbjerg, A., Knepper, M.A., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  3. Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome. Fernández-Llama, P., Andrews, P., Nielsen, S., Ecelbarger, C.A., Knepper, M.A. Kidney Int. (1998) [Pubmed]
  4. Reduced renal expression of AQP2, p-AQP2 and AQP3 in haemorrhagic shock-induced acute renal failure. Gong, H., Wang, W., Kwon, T.H., Jonassen, T., Frøkiaer, J., Nielsen, S. Nephrol. Dial. Transplant. (2003) [Pubmed]
  5. Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI. Kwon, T.H., Laursen, U.H., Marples, D., Maunsbach, A.B., Knepper, M.A., Frokiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  6. Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct. Nielsen, S., Terris, J., Andersen, D., Ecelbarger, C., Frokiaer, J., Jonassen, T., Marples, D., Knepper, M.A., Petersen, J.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney. Echevarria, M., Windhager, E.E., Tate, S.S., Frindt, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Ishibashi, K., Sasaki, S., Fushimi, K., Uchida, S., Kuwahara, M., Saito, H., Furukawa, T., Nakajima, K., Yamaguchi, Y., Gojobori, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Preisser, L., Teillet, L., Aliotti, S., Gobin, R., Berthonaud, V., Chevalier, J., Corman, B., Verbavatz, J.M. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  10. Altered expression of selected genes in kidney of rats with lithium-induced NDI. Rojek, A., Nielsen, J., Brooks, H.L., Gong, H., Kim, Y.H., Kwon, T.H., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  11. AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors. Wang, W., Li, C., Kwon, T.H., Knepper, M.A., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  12. Bronchiolar expression of aquaporin-3 (AQP3) in rat lung and its dynamics in pulmonary oedema. Sato, K., Kobayashi, K., Aida, S., Tamai, S. Pflugers Arch. (2004) [Pubmed]
  13. Regulation of collecting duct AQP3 expression: response to mineralocorticoid. Kwon, T.H., Nielsen, J., Masilamani, S., Hager, H., Knepper, M.A., Frokiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  14. Up-regulation of cochlear aquaporin-3 mRNA expression after intra-endolymphatic sac application of dexamethasone. Kitahara, T., Fukushima, M., Uno, Y., Mishiro, Y., Kubo, T. Neurol. Res. (2003) [Pubmed]
  15. Selective decreases in levels of mRNA encoding a water channel (AQP3) in ileal mucosa after ileostomy in the rat. Purdy, M.J., Cima, R.R., Doble, M.A., Klein, M.A., Zinner, M.J., Soybel, D.I. J. Gastrointest. Surg. (1999) [Pubmed]
  16. Glucocorticoid restores the deterioration of water transport in the peritoneum through increment in aquaporin. Imai, H., Nakamoto, H., Ishida, Y., Inoue, T., Kanno, Y., Okada, H., Suzuki, S., Okano, H., Suzuki, H. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. (2000) [Pubmed]
  17. Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. Nielsen, S., King, L.S., Christensen, B.M., Agre, P. Am. J. Physiol. (1997) [Pubmed]
  18. Increased renal ENaC subunit and sodium transporter abundances in streptozotocin-induced type 1 diabetes. Song, J., Knepper, M.A., Verbalis, J.G., Ecelbarger, C.A. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  19. Gentamicin decreases the abundance of aquaporin water channels in rat kidney. Lee, J., Yoo, K.S., Kang, D.G., Kim, S.W., Choi, K.C. Jpn. J. Pharmacol. (2001) [Pubmed]
  20. Expression of AQP family in rat kidneys during development and maturation. Yamamoto, T., Sasaki, S., Fushimi, K., Ishibashi, K., Yaoita, E., Kawasaki, K., Fujinaka, H., Marumo, F., Kihara, I. Am. J. Physiol. (1997) [Pubmed]
  21. cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion. Brooks, H.L., Ageloff, S., Kwon, T.H., Brandt, W., Terris, J.M., Seth, A., Michea, L., Nielsen, S., Fenton, R., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  22. Cell specificity of aquaporins 0, 3, and 10 expressed in the testis, efferent ducts, and epididymis of adult rats. Hermo, L., Krzeczunowicz, D., Ruz, R. J. Androl. (2004) [Pubmed]
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