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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

AT1 receptors mediate pressor responses induced by angiotensin II in the periaqueductal gray area of rats.

Microinjection of angiotensin II (ANGII) (0.01 to 1 nmol) into the periaqueductal gray area (PAG) of anaesthetised rats caused dose-dependent increases in blood pressure. Preinjection (10 min before) of losartan (a selective non-peptide AT1 receptor antagonist; 50 nmol) to the PAG reduced the pressor response to ANGII whereas PD123319 (a selective non-peptide AT2 receptor antagonist; 50 nmol) did not affect the ANGII-induced hypertension. Thus, our data suggest that the activation of AT1 but not AT2 receptors mediates ANGII-induced blood pressure changes in the PAG area.[1]

References

  1. AT1 receptors mediate pressor responses induced by angiotensin II in the periaqueductal gray area of rats. D'Amico, M., Di Filippo, C., Berrino, L., Rossi, F. Life Sci. (1997) [Pubmed]
 
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