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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ethchlorvynol (Placidyl)-induced pulmonary edema.

Two patients experienced severe nonhemodynamic pulmonary edema following the intravenous injection of 25 and 40 mg/kg of body weight of ethchlorvynol (Placidyl). The pulmonary edema cleared rapidly. Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. Injection of polyethylene glycol, the vehicle in which ethchlorvynol is diluted, did not reproduce the syndrome.[1]


  1. Ethchlorvynol (Placidyl)-induced pulmonary edema. Glauser, F.L., Smith, W.R., Caldwell, A., Hoshiko, M., Dolan, G.S., Baer, H., Olsher, N. Ann. Intern. Med. (1976) [Pubmed]
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