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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori.

Arylamine N-acetyltransferase (NAT) activities with p-aminobenzoic acid (PABA) and 2-aminofluorene (AF) were determined in H. pylori collected from peptic ulcer patients. Cytosols or suspensions of H. pylori with or without different concentrations of aloe-emodin co-treatment showed different percentages of AF and PABA acetylation. The data indicate that there was decreased NAT activity associated with increased aloe-emodin in H. pylori cytosols. Inhibition of growth study from H. pylori demonstrated that aloe-emodin elicited dose-dependent growth inhibition in H. pylori cultures. The report is the first finding of aloe-emodin inhibition of arylamine NAT activity in a strain of H. pylori.[1]

References

  1. Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori. Wang, H.H., Chung, J.G., Ho, C.C., Wu, L.T., Chang, S.H. Planta Med. (1998) [Pubmed]
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