Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Foltz, I.N. et al.

Human mitogen-activated protein kinase kinase 7 ( MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase ( JNK/ SAPK) activated by environmental stresses and physiological stimuli.

We report the cloning of a novel human activator of c-Jun N-terminal kinase ( JNK), mitogen-activated protein kinase kinase 7 ( MKK7). The mRNA for MKK7 is widely expressed in humans and mice and encodes a 47-kDa protein (419 amino acids), as determined by immunoblotting endogenous MKK7 with an antibody raised against its N terminus. The kinase domain of MKK7 is closely related to a Drosophila JNK kinase dHep (69% identity) and to a newly identified ortholog from Caenorhabditis elegans (54% identity), and was more distantly related to MKK4, MKK3, and MKK6. MKK7 phosphorylated and activated JNK1 but failed to activate p38 MAPK in co-expression studies. In hematopoietic cells, endogenous MKK7 was activated by treatment with the growth factor interleukin-3 (but not interleukin-4), or by ligation of CD40, the B-cell antigen receptor, or the receptor for the Fc fragment of immunoglobulin. MKK7 was also activated when cells were exposed to heat, UV irradiation, anisomycin, hyperosmolarity or the pro-inflammatory cytokine tumor necrosis factor-alpha. Co-expression of constitutively active mutants of RAS, RAC, or CDC42 in HeLa epithelial cells or of RAC or CDC42 in Ba/F3 factor-dependent hematopoietic cells also activated MKK7, suggesting that MKK7 will be involved in many physiological pathways.[1]

References

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. Foltz, I.N., Gerl, R.E., Wieler, J.S., Luckach, M., Salmon, R.A., Schrader, J.W. J. Biol. Chem. (1998) [Pubmed]

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